Susheel K. Gunasekar
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View article: Single catheter strategy for transradial angiography and primary percutaneous coronary intervention enhances procedural efficiency, microvascular outcomes, and cost-effectiveness: Implications for STEMI healthcare in resource-limited settings
Single catheter strategy for transradial angiography and primary percutaneous coronary intervention enhances procedural efficiency, microvascular outcomes, and cost-effectiveness: Implications for STEMI healthcare in resource-limited settings Open
Background Faster time to reperfusion can be achieved by minimizing various patient and system-level delays that contribute to total ischemic time. Procedural delays within the catheterization laboratory represent a non-negligible and modi…
View article: Effect of Fly Ash on the Strength Properties of Recycled Aggregate Concrete
Effect of Fly Ash on the Strength Properties of Recycled Aggregate Concrete Open
The rapid expansion of construction activities, coupled with the depletion of natural resources, necessitates the widespread adoption of recycling and reusing technologies within the construction sector. One such approach is the utilizatio…
View article: Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease
Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease Open
Healthy expansion of adipose tissue is critical for the maintenance of metabolic health, providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to effi…
View article: Evaluation study of hybrid fibre reinforced concrete using waste foundry sand and vermiculite
Evaluation study of hybrid fibre reinforced concrete using waste foundry sand and vermiculite Open
In this work, leftover foundry sand and vermiculite were used as partial replacements for fine and coarse aggregates in hybrid fibre reinforced concrete (HFRC). The study also concentrated on HFRC mix percentage optimization to achieve des…
View article: Improvement of corrosion resistance of concrete element by using nanotechnology
Improvement of corrosion resistance of concrete element by using nanotechnology Open
Fly ash is increasingly being used as a partial substitute in concrete mixtures. Thermal power plants produce fly ash, which seems to be a wasted item. In India, thermal power plants create over 105 million tonnes of fly ash each year, wit…
View article: An Innovative Approach on Pet Bottles Compiled with Waste Materials to Produce Eco-friendly Concrete
An Innovative Approach on Pet Bottles Compiled with Waste Materials to Produce Eco-friendly Concrete Open
PET bottles, such as water bottles, cool drink bottles, and oil storage bottles, are becoming increasingly popular in India. Bottles used to package water take over 1,000 years to biodegrade and, if incinerated, contain poisonous gases. Re…
View article: Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes Open
Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific SWELL1 ablation impairs insulin signaling in adipose, skeletal muscle, and endotheli…
View article: Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes
Small molecule SWELL1-LRRC8 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes Open
Type 2 diabetes (T2D) is associated with insulin resistance, impaired insulin secretion from the pancreatic β-cell, and nonalcoholic fatty liver disease (NAFLD). SWELL1 (LRRC8a) ablation impairs adipose and skeletal muscle insulin-pAKT2 si…
View article: The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function Open
The endothelium responds to numerous chemical and mechanical factors in regulating vascular tone, blood pressure, and blood flow. The endothelial volume-regulated anion channel (VRAC) has been proposed to be mechanosensitive and thereby se…
View article: Author response: The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
Author response: The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The endothelium responds to numerous chemi…
View article: Experimental Study of Sugarcane Bagasse Ash and Quarry Dust in Partial Replacement of Brick Material
Experimental Study of Sugarcane Bagasse Ash and Quarry Dust in Partial Replacement of Brick Material Open
For Economic, Environmental, and technical reasons, the use of industrial and agricultural waste products in industry has been the subject of research.Sugarcane Bagasse, like Ethanol vapor, is a fibrous waste product of the sugar refining …
View article: Durability Study on Fly Ash Aggregate Concrete with Respect to Carbonation Test
Durability Study on Fly Ash Aggregate Concrete with Respect to Carbonation Test Open
In this project, the durability of concrete with fly ash aggregates (FAA) is studied.M20 Grade concrete is selected and designed as per IS method.The project's major goal is to use (FAA) fly ash aggregates to replace traditional fine and c…
View article: SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism Open
Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show th…
View article: Author response: SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
Author response: SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Maintenance of skeletal muscl…
View article: The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function
The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS-mTOR signaling and vascular function Open
The endothelium responds to a multitude of chemical and mechanical factors in regulating vascular tone, angiogenesis, blood pressure and blood flow. The endothelial volume regulatory anion channel (VRAC) has been proposed to be mechano-sen…
View article: SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism
SWELL1-LRRC8 complex regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism Open
Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism, however the molecular mechanosensor remains unknown. Here, we show tha…
View article: Experimental Study on Manufacturing Artificial Aggregate from Various Industrial Waste and Its Applications in Concrete – A Critical Review
Experimental Study on Manufacturing Artificial Aggregate from Various Industrial Waste and Its Applications in Concrete – A Critical Review Open
The aim of this paper is to examine the production of artificial aggregate and its potential applications in concrete. The waste materials from industrial are one of the concern issues in sustainable development. Recycle and reuse these wa…
View article: Smart Sanitary Disposal System in Hard Rock Exposures Using Microbes
Smart Sanitary Disposal System in Hard Rock Exposures Using Microbes Open
Septic system plays a major role in sanitary disposal activities. In developing country it is very essential for proper disposal of wastes for providing clean environment. In our country the government has adopted scheme, “CLEAN INDIA”,. F…
View article: Effective Utilisation of Construction and Demolition Waste (Cdw) As Recycled Aggregate in Concrete Construction – A Critical Review
Effective Utilisation of Construction and Demolition Waste (Cdw) As Recycled Aggregate in Concrete Construction – A Critical Review Open
Solid wastes are the inevitable production of the operations of various industries like construction Industry, Machines Manufacturing Units, Textile industry etc. In India the construction industry generates large amounts of waste, which c…
View article: Potential Utilization of Sugarcane Bagasse Ash (Scba) In Concrete – An Experimental Review
Potential Utilization of Sugarcane Bagasse Ash (Scba) In Concrete – An Experimental Review Open
Sugar cane bagasse ash (SBCA) is a fibrous waste-product of the sugar refining industry. It is generated as a combustion by-product from boilers of sugar and alcohol factories. This is composed mainly by silica and this by-product can be u…
View article: Strength Property Study on Paver Block Made with Recycled Concrete Aggregates – An Experimental Review
Strength Property Study on Paver Block Made with Recycled Concrete Aggregates – An Experimental Review Open
With increase in population and urbanization, demand of raw materials such as cement and aggregate has increased in the construction industries. Further it has been recognized that waste from construction &demolition sectors are of large v…
View article: SWELL signalling in adipocytes: can fat 'feel' fat?
SWELL signalling in adipocytes: can fat 'feel' fat? Open
Obesity is becoming a global epidemic, predisposing to Type 2 diabetes, cardiovascular disease, fatty liver disease, pulmonary disease, osteoarthritis and cancer. Therefore, understanding the biology of adipocyte expansion in response to o…
View article: SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia Open
Insulin secretion is initiated by activation of voltage-gated Ca 2+ channels (VGCC) to trigger Ca 2+ -mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC requires β-cell membrane depolarization, which is reg…
View article: Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity
Induction of adipose and hepatic SWELL1 expression is required for maintaining systemic insulin-sensitivity in obesity Open
Obesity is associated with a loss of insulin-sensitivity and systemic dysglycemia, resulting in Type 2 diabetes, however the molecular mechanisms underlying this association are unclear. Through adipocyte patch-clamp studies, we recently s…
View article: <i>SWELL1</i>is a glucose sensor required for β-cell excitability and insulin secretion
<i>SWELL1</i>is a glucose sensor required for β-cell excitability and insulin secretion Open
Insulin secretion from the pancreatic β-cell initiated by activation of voltage-gated Ca 2+ channels (VGCC) to trigger Ca 2+ -mediated insulin vesicle fusion with the β-cell plasma membrane. The firing of VGCC depends on the β-cell membran…
View article: The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH
The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH Open
The leucine rich repeat containing protein 8A (LRRC8A), or SWELL1, is an essential component of the volume-regulated anion channel (VRAC) that is activated by cell swelling and ionic strength. We report here for the first time to our knowl…