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View article: The polyphenol - altilisol from Artocarpus altilis leaves exhibits angiotensin-I converting enzyme inhibitory activity
The polyphenol - altilisol from Artocarpus altilis leaves exhibits angiotensin-I converting enzyme inhibitory activity Open
Angiotensin-I converting enzyme (ACE) plays a central role in blood pressure regulation and is a key target in the treatment of hypertension. Although clinically used ACE inhibitors are effective, they are often associated with adverse eff…
View article: Pigmented Bowen’s disease − a rare clinical presentation
Pigmented Bowen’s disease − a rare clinical presentation Open
View article: Advancements in understanding and treating psoriasis: a comprehensive review of pathophysiology, diagnosis, and therapeutic approaches
Advancements in understanding and treating psoriasis: a comprehensive review of pathophysiology, diagnosis, and therapeutic approaches Open
Psoriasis is a chronic autoimmune disease affecting millions worldwide. This condition is characterized by scaly, red patches of skin that can be painful, itchy, and disfiguring. This non-contagious illness forms plaques and accelerates th…
View article: Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach
Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach Open
Background Alzheimer’s disease (AD) and glioblastoma (GBM) are complex neurological disorders with distinct pathologies but overlapping molecular mechanisms, including neuroinflammation, oxidative stress, and dysregulated signaling pathway…
View article: Network pharmacology and artificial intelligence in traditional Chinesemedicine for Alzheimer’s disease:Acomprehensive review
Network pharmacology and artificial intelligence in traditional Chinesemedicine for Alzheimer’s disease:Acomprehensive review Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by the accumulation of amyloid-beta, tau hyperphosphorylation, neuroinflammation, and oxidative stress. With current pharmacological treatments providing s…
View article: Leveraging compact convolutional transformers for enhanced COVID-19 detection in chest X-rays: a grad-CAM visualization approach
Leveraging compact convolutional transformers for enhanced COVID-19 detection in chest X-rays: a grad-CAM visualization approach Open
View article: Sustainable synthesis of zinc oxide nanoparticles using Piper betle petiole leaf extract: Antibacterial, antioxidant, and cytotoxic potential
Sustainable synthesis of zinc oxide nanoparticles using Piper betle petiole leaf extract: Antibacterial, antioxidant, and cytotoxic potential Open
The present study used Piper betle petiole leaf extract as an efficient reducing agent to produce zinc oxide nanoparticles (ZnO NPs). The change in the color of reaction mixture from brown to white indicates the formation of ZnO NPs, which…
View article: Identifying the lead molecule from Carica papaya using computer-aided drug design technique against streptococcus pneumoniae
Identifying the lead molecule from Carica papaya using computer-aided drug design technique against streptococcus pneumoniae Open
Streptococcus pneumoniae, a gram-positive cocci bacterium found in the oral cavity and nasopharynx of humans causes acute respiratory infections and pneumonia progression. This study aims to identify highly susceptible, antimicrobial, ther…
View article: Computational exploration of Picrasma quassioides compounds as CviR-mediated quorum sensing inhibitors against Chromobacterium violaceum
Computational exploration of Picrasma quassioides compounds as CviR-mediated quorum sensing inhibitors against Chromobacterium violaceum Open
Chromobacterium violaceum an opportunistic human pathogenic bacterium, exhibits resistance to conventional antibiotics by exploiting its quorum sensing mechanism to regulate virulence factor expression. In light of this, disrupting the quo…
View article: Association between Usage of Prophylactic AYUSH Medicines and Disease Severity in COVID-19 Patients: A Retrospective Cohort Study
Association between Usage of Prophylactic AYUSH Medicines and Disease Severity in COVID-19 Patients: A Retrospective Cohort Study Open
Background Prior vaccination is often studied for its impact on individuals' post-infection prognosis. Ayurveda, Yoga, Unani, Siddha and Homeopathy (AYUSH) medicines, advised by the Government of India as prophylaxis during the first wave …
View article: Secondary metabolites of Trichoderma spp. as EGFR tyrosine kinase inhibitors: Evaluation of anticancer efficacy through computational approach
Secondary metabolites of Trichoderma spp. as EGFR tyrosine kinase inhibitors: Evaluation of anticancer efficacy through computational approach Open
The present study explores the epidermal growth factor receptor (EGFR) tyrosine kinase inhibition efficacy of secondary metabolites in Trichoderma spp. through molecular docking, molecular dynamics (MD) simulation and MM-PBSA approach. The…
View article: Synthesis And Evaluation Of Benzimidazole For Their Antimicrobial Activity
Synthesis And Evaluation Of Benzimidazole For Their Antimicrobial Activity Open
View article: Descriptive And Multiple Linear Regression Analysis Of Water Quality Parameters Of Vidyaranyapuram Treatment Plant: A Case Study
Descriptive And Multiple Linear Regression Analysis Of Water Quality Parameters Of Vidyaranyapuram Treatment Plant: A Case Study Open
The fundamental need of human beings is safe water, but urban development is generating more polluted water creating the scarcity for drinkable water. Wastewater plants are used reduce the pollutants to less than maximum permissible limits…
View article: Plant Derived Bioactive Compounds, Their Anti-Cancer Effects as an Alternative Target Treatment Strategy for Breast Cancer: An Updated Overview
Plant Derived Bioactive Compounds, Their Anti-Cancer Effects as an Alternative Target Treatment Strategy for Breast Cancer: An Updated Overview Open
For decades, cancer has been a major public health concern worldwide owing to its high mortality rate. Many therapeutic strategies have come up in the scientific world, but it's pitiful to know that synthetic chemotherapeutic agents either…
View article: Cell cycle arrest and apoptotic studies of Terminalia chebula against MCF-7 breast cancer cell line: an in vitro and in silico approach
Cell cycle arrest and apoptotic studies of Terminalia chebula against MCF-7 breast cancer cell line: an in vitro and in silico approach Open
Breast cancer is a leading cause of mortality in women, and alternative therapies with fewer side effects are actively being explored. Breast cancer is a significant global health concern, and conventional treatments like radiotherapy and …
View article: Assessment of antimicrobial and anthelmintic activity of silver nanoparticles bio-synthesized from Viscum orientale leaf extract
Assessment of antimicrobial and anthelmintic activity of silver nanoparticles bio-synthesized from Viscum orientale leaf extract Open
Background Viscum orientale is a largely used parasitic plant with traditional medicinal properties. They are considered to possess the medicinal properties of host tree which they grow on. It’s a least explored plant with ethanopharmacolo…
View article: Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries
Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries Open
: Tomato yellow leaf curl virus (TYLCV) is a major devastating viral disease, majorly affecting the tomato production globally. The disease is majorly transmitted by the Whitefly. The Begomovirus (TYLCV) having a six major protein coding g…
View article: In silico examination of peptides containing selenium and ebselen Backbone To Assess Their Tumoricidal Potential
In silico examination of peptides containing selenium and ebselen Backbone To Assess Their Tumoricidal Potential Open
Introduction: Cancer has been one of the highest causes of morbidity and mortality in the world for decades. Owing to improved therapeutics along with detection, breast cancer mortality has been slowly reducing. The incidence of breast can…
View article: Author Correction: Integrated approach for studying bioactive compounds from Cladosporium spp. against estrogen receptor alpha as breast cancer drug target
Author Correction: Integrated approach for studying bioactive compounds from Cladosporium spp. against estrogen receptor alpha as breast cancer drug target Open
View article: In Silico Computational Studies of Bioactive Secondary Metabolites from Wedelia trilobata against Anti-Apoptotic B-Cell Lymphoma-2 (Bcl-2) Protein Associated with Cancer Cell Survival and Resistance
In Silico Computational Studies of Bioactive Secondary Metabolites from Wedelia trilobata against Anti-Apoptotic B-Cell Lymphoma-2 (Bcl-2) Protein Associated with Cancer Cell Survival and Resistance Open
In the present study, the binding affinity of 52 bioactive secondary metabolites from Wedelia trilobata towards the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein (PDB: 2W3L) structure was identified by using in silico molecular docking …
View article: Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach
Evaluating the Antimicrobial and Anti-Hemolytic Activity of Synthesized Pseudopeptide against Leptospiral Species: In Silico and In Vitro Approach Open
Bacterial infections are one of the leading causes of morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be the most prevalent, re-emergent, and neglected tropical zoonotic disease worldwide. The adap…
View article: Eco-friendly synthesis of MnO2 nanoparticles using Saraca asoca leaf extract and evaluation of in vitro anticancer activity
Eco-friendly synthesis of MnO2 nanoparticles using Saraca asoca leaf extract and evaluation of in vitro anticancer activity Open
Manganese oxide nanoparticles (MnO2 NPs) were synthesized through a simple one-pot green synthesis method using Saraca asoca leaves extract (SA-MnO2 NPs), and their physicochemical properties were characterized using various analytical tec…
View article: <i>In vitro</i> anticancer evaluation of Enceleamycin A and its underlying mechanism
<i>In vitro</i> anticancer evaluation of Enceleamycin A and its underlying mechanism Open
Enceleamycin A a candidate molecule for treating TNBC cells by targeting the AKT2 signaling pathway.
View article: Bio prospecting of Lapachol producing endophytic fungi
Bio prospecting of Lapachol producing endophytic fungi Open
Background: The association of endophytic fungi with medicinal plants has been one of the evolving areas of research in the past few decades. The secondary metabolites produced owing to such associations have been recognised for a wide ran…
View article: Artificial intelligence and Machine Learning based Techniques in Analyzing the COVID-19 Gene Expression data: A Review
Artificial intelligence and Machine Learning based Techniques in Analyzing the COVID-19 Gene Expression data: A Review Open
The novel Coronavirus associated with respiratory illness has become a new threat to human health as it is spreading very rapidly among the human population. Scientists and healthcare specialists throughout the world are still looking for …
View article: Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries
Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries Open
Tomato yellow leaf curl virus (TYLCV) is a major devastating viral disease, majorly affecting the tomato production globally. The disease is majorly transmitted by the Whitefly. The Begomovirus (TYLCV) having a six major protein coding gen…
View article: Anticholinesterase activity of Areca Catechu: In Vitro and in silico green synthesis approach in search for therapeutic agents against Alzheimer’s disease
Anticholinesterase activity of Areca Catechu: In Vitro and in silico green synthesis approach in search for therapeutic agents against Alzheimer’s disease Open
For many years, the primary focus has been on finding effective treatments for Alzheimer’s disease (AD), which has led to the identification of promising therapeutic targets. The necessity for AD stage-dependent optimal settings necessitat…
View article: Phytoconstituents of Withania somnifera unveiled Ashwagandhanolide as a potential drug targeting breast cancer: Investigations through computational, molecular docking and conceptual DFT studies
Phytoconstituents of Withania somnifera unveiled Ashwagandhanolide as a potential drug targeting breast cancer: Investigations through computational, molecular docking and conceptual DFT studies Open
Breast cancer is the second most common malignancy in females worldwide and poses a great challenge that necessitates the identification of novel therapeutic agents from several sources. This research aimed to study the molecular docking a…
View article: Computational Approach Assessing the Antibacterial Activity of Acorus calamus Against Helicobacter pylori
Computational Approach Assessing the Antibacterial Activity of Acorus calamus Against Helicobacter pylori Open
Helicobacter pylori is a gram-negative, microaerophilic bacteria that lives in the stomach of most of the human population. Overview of novel alternatives utilizing common natural phytochemicals has been demonstrated as powerful tools in b…