Sushma R. Rao
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View article: Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival
Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival Open
Cancer cells exhibit accelerated protein production to accommodate their high rates of growth and proliferation. Elevated protein synthesis creates a dependency on endoplasmic reticulum (ER)-resident proteins and chaperones, which are requ…
View article: The Effect of Artificial Intelligence on Global Cinema Business and Cinematic Narratives
The Effect of Artificial Intelligence on Global Cinema Business and Cinematic Narratives Open
The purpose of this study is to explore the profound impact of artificial intelligence (AI) on the intersection of global cinema business and cinematic narratives, with a specific focus on select Indian films. As AI technologies continue t…
View article: The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits
The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits Open
View article: Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment
Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment Open
View article: The Role of Pregnancy Associated Plasma Protein-A in Triple Negative Breast Cancer: A Promising Target for Achieving Clinical Benefits
The Role of Pregnancy Associated Plasma Protein-A in Triple Negative Breast Cancer: A Promising Target for Achieving Clinical Benefits Open
Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This subtype accounts for the most aggressive BC, possesses high tumor heterogeneity, is least re…
View article: THE CINEMATIC FEMININE
THE CINEMATIC FEMININE Open
Popular cinema today is not just mere entertainment. It can help us understand human nature and the ethical theory that underpins it. Cinema’s power to influence is what makes it a perfect platform for ethical portrayals. Feministic Cinema…
View article: Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer
Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer Open
Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype presents with an aggressive clinical course, heightened metast…
View article: FAST-IT:<i>F</i>ind<i>A S</i>imple<i>T</i>est —<i>I</i>n<i>T</i>IA (transient ischaemic attack): a prospective cohort study to develop a multivariable prediction model for diagnosis of TIA through proteomic discovery and candidate lipid mass spectrometry, neuroimaging and machine learning—study protocol
FAST-IT:<i>F</i>ind<i>A S</i>imple<i>T</i>est —<i>I</i>n<i>T</i>IA (transient ischaemic attack): a prospective cohort study to develop a multivariable prediction model for diagnosis of TIA through proteomic discovery and candidate lipid mass spectrometry, neuroimaging and machine learning—study protocol Open
Introduction Transient ischaemic attack (TIA) may be a warning sign of stroke and difficult to differentiate from minor stroke and TIA-mimics. Urgent evaluation and diagnosis is important as treating TIA early can prevent subsequent stroke…
View article: Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells Open
Cells within solid tumours can become deprived of nutrients; in order to survive, they need to invoke mechanisms to conserve these resources. Using cancer cells in culture in the absence of key nutrients, we have explored the roles of two …
View article: SemifreddoNets: Partially Frozen Neural Networks for Efficient Computer\n Vision Systems
SemifreddoNets: Partially Frozen Neural Networks for Efficient Computer\n Vision Systems Open
We propose a system comprised of fixed-topology neural networks having\npartially frozen weights, named SemifreddoNets. SemifreddoNets work as\nfully-pipelined hardware blocks that are optimized to have an efficient\nhardware implementatio…
View article: Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study
Developing a multivariable prediction model for functional outcome after reperfusion therapy for acute ischaemic stroke: study protocol for the Targeting Optimal Thrombolysis Outcomes (TOTO) multicentre cohort study Open
Introduction Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the only approved pharmacological reperfusion therapy for acute ischaemic stroke. Despite population benefit, IVT is not equally effective…
View article: The Clathrin-dependent Spindle Proteome
The Clathrin-dependent Spindle Proteome Open
The mitotic spindle is required for chromosome congression and subsequent equal segregation of sister chromatids. These processes involve a complex network of signaling molecules located at the spindle. The endocytic protein, clathrin, has…