Explanipedia

Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis Open

Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska V. Kraus , et al. · 2023

CD40 induces selective routing of Ras isoforms to subcellular compartments Open

Arathi Nair, Sushmita Chakraborty, Bhaskar Saha · 2023

Ras GTPases are central to cellular signaling and oncogenesis. The three loci of the Ras gene encode for four protein isoforms namely Harvey-Ras (H-Ras), Kirsten-Ras (K-Ras 4A and 4B), and Neuroblastoma-Ras (N-Ras) which share ~ 80% sequen…

Gαq modulates the energy metabolism of osteoclasts Open

Sushmita Chakraborty, Bianca Handrick, Dayoung Yu, Konrad A. Bode, Anna Hafner , et al. · 2023

Introduction The bacterial protein toxin Pasteurella multocida toxin (PMT) mediates RANKL-independent osteoclast differentiation. Although these osteoclasts are smaller, their resorptive activity is high which helps in efficient destructio…

Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation Open

Yue Gao, Franziska V. Kraus, Elisabeth Seebach, Sushmita Chakraborty, D Schaack , et al. · 2022

Immune cells undergo metabolic reprogramming upon exposure to inflammatory stimuli. The immuneresponsive gene 1 ( Irg1 ) encodes aconitate decarboxylase (Acod1), an enzyme that generates itaconate from cis-aconitate in the TCA cycle and is…

INHIBITING PD-1 PATHWAY RESCUES PROTECTIVE IMMUNE RESPONSE IN TB PATIENTS: IMPACT ON BACILLARY EFFLUX PUMP AND MULTIDRUG-RESISTANCE TB Open

Dipendra Kumar Mitra, Divya Kamboj, Gopika Gupta, G. Mehta, Sushmita Chakraborty , et al. · 2021

A Significant Study on Emerging Technologies in Smart Cities for Planet Earth during Covid-19 Pandemic Open

Sushmita Chakraborty, Ajit Singh · 2021

The Covid-19 pandemic is having a huge global impact, especially when we talk about Internet of Things (IoT) and market analysts to analyze the impact of the pandemic on smart cities and also to understand what are the new responses, chall…

Successful reconstitution of leukocyte adhesion defect after umbilical cord blood stem cell transplant Open

Sushmita Chakraborty, Devika Gupta, Deepshi Thakral, Sameer Bakhshi, Prabin Kumar , et al. · 2020

Leukocyte adhesion deficiencies (LADs) are a type of primary immunodeficiencies characterized by delayed detachment of the umbilical cord, impaired wound healing, leukocytosis, and recurrent infections. The disease is caused by genetic def…

MOESM1 of Ras isoforms: signaling specificities in CD40 pathway Open

Arathi Nair, Sushmita Chakraborty, Late Anirban Banerji, Ankita Srivastava, Charudutta Navare , et al. · 2020

Additional file 1. Figure S1. (A) Densitometry for immunoblot analysis for the silencing of Ras isoforms H, K, and N-Ras using specific siRNA. (B-D) Densitometry for immunoblots for phosphorylation of p38MAPK and ERK1/2 in P388D1 cells sil…

Post Transplant Lymphoproliferative Disorder Open

Devika Gupta, Satish Mendonca, Sushmita Chakraborty, Tathagata Chatterjee · 2019

An Update on Interleukin-9: From Its Cellular Source and Signal Transduction to Its Role in Immunopathogenesis Open

Sushmita Chakraborty, Katharina F. Kubatzky, Dipendra Kumar Mitra · 2019

Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T helper 2 (TH2)-associated immuno-pathological conditions such as asthma and parasitic infections. There was a paradigm shift in the biology of IL-…

The Significance of People and Sensors in Smart Cities Open

Ajit Singh, Sushmita Chakraborty · 2019

Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation Open

Bianca Kloos, Sushmita Chakraborty, Sonja G. Lindner, Katrin Noack, Ulrike Harre , et al. · 2015

Activation of mTOR signalling plays a central role in the formation of osteoclasts through the bacterial toxin PMT. On the molecular level, PMT-induced activation of mTOR leads to down regulation of PDCD4, a known repressor of AP-1 complex…

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