Sushmita Mustafi
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View article: Data from Vitamin C Sensitizes Melanoma to BET Inhibitors
Data from Vitamin C Sensitizes Melanoma to BET Inhibitors Open
Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in phase I clinical trials. Here, we screened a panel of small molecules targeting epi…
View article: Data from Vitamin C Sensitizes Melanoma to BET Inhibitors
Data from Vitamin C Sensitizes Melanoma to BET Inhibitors Open
Bromodomain and extraterminal inhibitors (BETi) are promising cancer therapies, yet prominent side effects of BETi at effective doses have been reported in phase I clinical trials. Here, we screened a panel of small molecules targeting epi…
View article: Supplemental info from Vitamin C Sensitizes Melanoma to BET Inhibitors
Supplemental info from Vitamin C Sensitizes Melanoma to BET Inhibitors Open
This file contains the following supplementary figures, tables and other materials. Figure S1: The expression of BRD2, BRD3 and BRD4 in melanocytes and melanoma cells. Figure S2: Knocking down the expression of BRD4 by siRNA. Figure S3: Th…
View article: Supplemental info from Vitamin C Sensitizes Melanoma to BET Inhibitors
Supplemental info from Vitamin C Sensitizes Melanoma to BET Inhibitors Open
This file contains the following supplementary figures, tables and other materials. Figure S1: The expression of BRD2, BRD3 and BRD4 in melanocytes and melanoma cells. Figure S2: Knocking down the expression of BRD4 by siRNA. Figure S3: Th…
View article: Vitamin C sensitizes triple negative breast cancer to PI3K inhibition therapy
Vitamin C sensitizes triple negative breast cancer to PI3K inhibition therapy Open
Rationale: The clinical use of PI3K inhibitors, such as buparlisib, has been plagued with toxicity at effective doses. The aim of this study is to determine if vitamin C, a potent epigenetic regulator, can improve the therapeutic outcome a…
View article: Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro‐myelinating genes
Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro‐myelinating genes Open
Ascorbic acid (vitamin C) is critical for Schwann cells to myelinate peripheral nerve axons during development and remyelination after injury. However, its exact mechanism remains elusive. Vitamin C is a dietary nutrient that was recently …
View article: Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2 Open
Vitamin C supplementation has been shown to decrease triple-negative breast cancer (TNBC) metastasis. However, the molecular mechanism whereby vitamin C inhibits metastasis remains elusive. It has been postulated that vitamin C reduces the…
View article: Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells Open
Ascorbate inhibits VEGF expression in RPE cells likely via DNA hydroxymethylation. Thus, ascorbate could be implicated in the prevention or treatment of diseases such as age-related macular degeneration (AMD).
View article: cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool Open
It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple…
View article: cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool
cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool Open
It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple…
View article: Biomedical Properties and Origins of Sesquiterpene Lactones, with a Focus on Dehydroleucodine
Biomedical Properties and Origins of Sesquiterpene Lactones, with a Focus on Dehydroleucodine Open
Dehydroleucodine, a sesquiterpene lactone, belongs to the terpenoid class of secondary metabolites. Dehydroleucodine and other Artemisia-derived phytochemicals evolved numerous biodefenses that were first co-opted for human pharmacological…