Sushmita Sridhar
YOU?
Author Swipe
View article: Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers
Insights Into Global Antimicrobial Resistance Dynamics Through the Sequencing of Enteric Bacteria From US International Travelers Open
Background Antimicrobial resistance (AMR) is an urgent threat to public health, but gaps in surveillance limit the detection of emergent novel threats and knowledge about the global distribution of AMR genes. International travelers freque…
View article: Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study
Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study Open
View article: Insights into global antimicrobial resistance dynamics through the sequencing of enteric bacteria from U.S. international travelers
Insights into global antimicrobial resistance dynamics through the sequencing of enteric bacteria from U.S. international travelers Open
Antimicrobial resistance (AMR) is an urgent threat to public health, but gaps in surveillance limit the detection of emergent novel threats and knowledge about the global distribution of AMR genes. International travelers frequently acquir…
View article: High Prevalence of Carbapenem-resistant <i>Klebsiella Pneumoniae</i> in Fecal and Water Samples in Dhaka, Bangladesh
High Prevalence of Carbapenem-resistant <i>Klebsiella Pneumoniae</i> in Fecal and Water Samples in Dhaka, Bangladesh Open
We evaluated Klebsiella pneumoniae (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in a…
View article: Multiplexed real-time PCR for the detection and differentiation of <i>Klebsiella pneumoniae</i> O-antigen serotypes
Multiplexed real-time PCR for the detection and differentiation of <i>Klebsiella pneumoniae</i> O-antigen serotypes Open
Klebsiella pneumoniae has emerged as a global health threat due to its role in the spread of antimicrobial resistance and because it is a frequent cause of hospital-acquired infections and neonatal sepsis. Capsular and lipopolysaccharide (…
View article: Antibody responses in<i>Klebsiella pneumoniae</i>bloodstream infection: a cohort study
Antibody responses in<i>Klebsiella pneumoniae</i>bloodstream infection: a cohort study Open
Summary Background Klebsiella pneumonia (Kpn) is the fourth leading cause of infection-related deaths globally, yet little is known about human antibody responses to invasive Kpn. In this study, we sought to determine whether the O-specifi…
View article: Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium
Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium Open
Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Presently we rely on exposing single organisms to an antimicrobial and growth to determine susceptibility; throughput and interpretation h…
View article: Gut microbiome perturbation, antibiotic resistance, and Escherichia coli strain dynamics associated with international travel: a metagenomic analysis
Gut microbiome perturbation, antibiotic resistance, and Escherichia coli strain dynamics associated with international travel: a metagenomic analysis Open
View article: 180. Alterations to the Gut Microbiomes and Acquisition of Bacteria Resistance Elements among US International Travelers
180. Alterations to the Gut Microbiomes and Acquisition of Bacteria Resistance Elements among US International Travelers Open
Background This study investigated the impact of international travel on the acquisition and carriage of antimicrobial resistance (AMR). We prospectively assessed U.S. international travelers for the acquisition of resistant Enterobacteral…
View article: Antimicrobial-resistant bacteria in international travelers
Antimicrobial-resistant bacteria in international travelers Open
Purpose of review Antimicrobial resistance (AMR) in bacteria poses a major risk to global public health, with many factors contributing to the observed increase in AMR. International travel is one recognized contributor. The purpose of thi…
View article: Author response: Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections
Author response: Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract SARS-CoV-2 is notable both fo…
View article: Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of<i>Salmonella</i>Typhimurium
Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of<i>Salmonella</i>Typhimurium Open
Antimicrobial resistance (AMR) is a pressing global health crisis, which has been fuelled by the sustained use of certain classes of antimicrobials, including fluoroquinolones. While the genetic mutations responsible for decreased fluoroqu…
View article: Klebsiella Pneumoniae ST258 Stimulates an Immunotolerant Host Metabolic Response That Promotes Bacterial Persistence
Klebsiella Pneumoniae ST258 Stimulates an Immunotolerant Host Metabolic Response That Promotes Bacterial Persistence Open
View article: Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19
Correction to: Ventilator-associated pneumonia in critically ill patients with COVID-19 Open
View article: Superspreaders drive the largest outbreaks of hospital onset COVID-19 infection
Superspreaders drive the largest outbreaks of hospital onset COVID-19 infection Open
SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of superspreading behaviour. Here, we applied a novel network reconstruction algorithm to infer …
View article: High-content imaging to phenotype antimicrobial effects on individual bacteria at scale
High-content imaging to phenotype antimicrobial effects on individual bacteria at scale Open
High-content imaging (HCI) is technique for screening multiple cells in high resolution to detect subtle morphological and phenotypic variation. The method has been commonly deployed on model eukaryotic cellular systems, often for screenin…
View article: A2B-COVID: A method for evaluating potential SARS-CoV-2 transmission events
A2B-COVID: A method for evaluating potential SARS-CoV-2 transmission events Open
Identifying linked cases of infection is a key part of the public health response to viral infectious disease. Viral genome sequence data is of great value in this task, but requires careful analysis, and may need to be complemented by add…
View article: An integrated approach to ciprofloxacin susceptibility analysis and high-throughput bacterial phenotyping in Salmonella
An integrated approach to ciprofloxacin susceptibility analysis and high-throughput bacterial phenotyping in Salmonella Open
Antimicrobial resistance is a growing threat across the world. Salmonella are Gram-negative, motile, rod-shaped bacteria that are transmitted through the faecal-oral route and invade the small intestine to cause self-limiting gastroenterit…
View article: Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study
Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study Open
View article: Secondary pneumonia in critically ill ventilated patients with COVID-19
Secondary pneumonia in critically ill ventilated patients with COVID-19 Open
Background Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) for invasive artific…
View article: Author response: Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19
Author response: Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19 Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Previously, we showed that 3% (31/1032)of …
View article: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission Open
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3-week period (April 2020), 1,…
View article: Rapid implementation of real-time SARS-CoV-2 sequencing to investigate healthcare-associated COVID-19 infections
Rapid implementation of real-time SARS-CoV-2 sequencing to investigate healthcare-associated COVID-19 infections Open
Background The burden and impact of healthcare-associated COVID-19 infections is unknown. We aimed to examine the utility of rapid sequencing of SARS-CoV-2 combined with detailed epidemiological analysis to investigate healthcare-associate…
View article: Author response: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
Author response: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Significant differences exist…
View article: A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities
A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities Open
The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the provision of additional diagnostic capacity. Academic laboratories, many of which…
View article: An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation Open
View article: Inherent Variability of Growth Media Impacts the Ability of Salmonella Typhimurium to Interact with Host Cells
Inherent Variability of Growth Media Impacts the Ability of Salmonella Typhimurium to Interact with Host Cells Open
Efficient invasion of non-phagocytic cells, such as intestinal epithelial cells, by Salmonella Typhimurium is dependent on the Salmonella Pathogenicity Island 1 (SPI-1)-encoded Type Three Secretion System. The environmental cues involved i…
View article: Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer
Integrative Genomics Implicates EGFR as a Downstream Mediator in NKX2-1 Amplified Non-Small Cell Lung Cancer Open
NKX2-1, encoding a homeobox transcription factor, is amplified in approximately 15% of non-small cell lung cancers (NSCLC), where it is thought to drive cancer cell proliferation and survival. However, its mechanism of action remains large…