Susie Y. Huang
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View article: GACELLE: GPU-accelerated tools for model parameter estimation and image reconstruction
GACELLE: GPU-accelerated tools for model parameter estimation and image reconstruction Open
Quantitative MRI (qMRI) offers tissue-specific biomarkers that can be tracked over time or compared across populations; however, its adoption in clinical research is hindered by significant computational demands of parameter estimation. Im…
View article: Age‐Related Alterations in Hippocampal Microstructure Quantified Using High‐Gradient Diffusion <scp>MRI</scp> ( <scp>dMRI</scp> ) in an Unfolded Hippocampal Space
Age‐Related Alterations in Hippocampal Microstructure Quantified Using High‐Gradient Diffusion <span>MRI</span> ( <span>dMRI</span> ) in an Unfolded Hippocampal Space Open
The hippocampus, a brain region critical for memory, undergoes significant age‐related changes at both the macroscopic and microstructural levels. This study investigates these changes using high‐gradient diffusion MRI (dMRI) data analyzed…
View article: Retrospective Review of MR Findings in Sudden Sensorineural Hearing Loss and Associated Clinical Features
Retrospective Review of MR Findings in Sudden Sensorineural Hearing Loss and Associated Clinical Features Open
Most patients showed no retrocochlear pathology on MRI, with only 2.7% having relevant tumors. To screen for urgent pathology, a noncontrast MR protocol may be feasible. Clinical features such as high PTA values and tinnitus may increase t…
View article: eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates
eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates Open
View article: Motion-Informed 3D Deep Learning Reconstruction in Patients with Cognitive Impairment
Motion-Informed 3D Deep Learning Reconstruction in Patients with Cognitive Impairment Open
Motion-informed DL reconstruction improved both morphometric accuracy and perceived image quality on 3D T1-weighted brain MRI. This technique may enhance diagnostic utility and reduce scan failure rates in motion-prone patients with cognit…
View article: Distinct cellular processes drive motor skill learning in the human brain
Distinct cellular processes drive motor skill learning in the human brain Open
Despite decades of research, the biological mechanisms by which motor skills consolidate in the human brain remain poorly understood. Diffusion MRI provides a unique opportunity to probe biological processes non-invasively, as water displa…
View article: eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates
eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates Open
View article: First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions
First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions Open
NCT04699747, Start date March 25th, 2021.
View article: Publisher Correction: Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales
Publisher Correction: Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales Open
View article: Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales
Ultra-high gradient connectomics and microstructure MRI scanner for imaging of human brain circuits across scales Open
Defining the connectome, the complete matrix of structural connections between the nervous system nodes, is a challenge for human systems neuroscience due to the range of scales that must be bridged. Here we report the design of the Connec…
View article: Leadership in radiology in the era of technological advancements and artificial intelligence
Leadership in radiology in the era of technological advancements and artificial intelligence Open
Radiology has evolved from the pioneering days of X-ray imaging to a field rich in advanced technologies on the cusp of a transformative future driven by artificial intelligence (AI). As imaging workloads grow in volume and complexity, and…
View article: Comparative Systematic Analysis of Gray Matter Biophysical Models on a public dataset
Comparative Systematic Analysis of Gray Matter Biophysical Models on a public dataset Open
Biophysical models of diffusion tailored to characterize gray matter (GM) microstructure are gaining traction in the neuroimaging community. NEXI, SMEX, SANDI, and SANDIX represent recent efforts to incorporate different microstructural fe…
View article: High‐density MRI coil arrays with integrated field monitoring systems for human connectome mapping
High‐density MRI coil arrays with integrated field monitoring systems for human connectome mapping Open
Purpose To develop and test two high‐density MRI coil arrays with integrated field monitoring systems for enhanced diffusion imaging with strong diffusion‐sensitizing gradients. Methods Two multichannel head coils were constructed for firs…
View article: Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI
Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI Open
Characterizing cortical laminar microstructure is essential for understanding human brain function. Leveraging the next-generation Connectome MRI scanner (maximum gradient strength = 500mT/m, slew rate = 600T/m/s), we characterized in vivo…
View article: Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation
Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation Open
Short-range association fibers (SAFs) are critical for cortical communications but are often underestimated in conventional resolution diffusion magnetic resonance imaging (dMRI) since they locate within a ∼1.5mm thin layer of superficial …
View article: Strong gradients, cool performance: A 64‐channel array coil with concurrent field monitoring and thermal control for ex vivo diffusion‐weighted brain imaging using the 3T connectome 2.0 MRI scanner
Strong gradients, cool performance: A 64‐channel array coil with concurrent field monitoring and thermal control for ex vivo diffusion‐weighted brain imaging using the 3T connectome 2.0 MRI scanner Open
Purpose High‐resolution ex vivo diffusion‐weighted imaging (dMRI) with high ‐values presents significant challenges, including low signal‐to‐noise ratio (SNR), magnetic field perturbations, and temperature‐related measurement shifts. This …
View article: Deep-learning-accelerated T1-MPRAGE MRI for quantification and visual grading of cerebral volume in memory loss patients
Deep-learning-accelerated T1-MPRAGE MRI for quantification and visual grading of cerebral volume in memory loss patients Open
Purpose To evaluate a physics-based deep-learning-accelerated super-resolution T1-weighted MPRAGE sequence (DL-MPRAGE) against standard 3-dimensional T1-weighted MPRAGE (STD-MPRAGE) for quantitative and qualitative regional cortical volume…
View article: In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects
In vivo cortical microstructure mapping using high-gradient diffusion MRI accounting for intercompartmental water exchange effects Open
View article: eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates
eLife Assessment: Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates Open
View article: Physics-informed deep learning reconstruction for ultrafast clinical 3D fluid-attenuated inversion recovery brain MRI
Physics-informed deep learning reconstruction for ultrafast clinical 3D fluid-attenuated inversion recovery brain MRI Open
Background Physics-informed deep learning (DL) reconstructions show promise in accelerating MRI yet have not been extensively validated, particularly for 3D fluid-attenuated inversion recovery (FLAIR) sequence. Purpose To evaluate the diag…
View article: Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning
Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning Open
Short-range association fibers located in the superficial white matter play an important role in mediating higher-order cognitive function in humans. Detailed morphological characterization of short-range association fibers at the microsco…
View article: Impact of optimized and conventional facility designs on outpatient abdominal MRI workflow efficiency
Impact of optimized and conventional facility designs on outpatient abdominal MRI workflow efficiency Open
The optimized MRI facility demonstrated superior outpatient workflow efficiency compared to an already efficient reference facility, particularly in table turnover time, resulting in increased patient throughput for abdominal MRI examinati…
View article: Simultaneous <scp>3D</scp> quantitative magnetization transfer imaging and susceptibility mapping
Simultaneous <span>3D</span> quantitative magnetization transfer imaging and susceptibility mapping Open
Purpose Introduce a unified acquisition and modeling strategy to simultaneously quantify magnetization transfer (MT), tissue susceptibility () and . Theory and Methods Magnetization transfer is induced through the application of off‐resona…
View article: Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain
Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain Open
Axon diameter and myelin thickness affect the conduction velocity of action potentials in the nervous system. Imaging them non-invasively with MRI-based methods is, thus, valuable for studying brain microstructure and function. Electron mi…
View article: <i>In vivo</i> human neurite exchange time imaging at 500 mT/m diffusion gradients
<i>In vivo</i> human neurite exchange time imaging at 500 mT/m diffusion gradients Open
Evaluating tissue microstructure and membrane integrity in the living human brain through diffusion water exchange imaging is challenging due to requirements for a high signal-to-noise ratio and short diffusion times dictated by relatively…
View article: <i>In vivo</i>human neurite exchange imaging (NEXI) at 500 mT/m diffusion gradients
<i>In vivo</i>human neurite exchange imaging (NEXI) at 500 mT/m diffusion gradients Open
Evaluating tissue microstructure and membrane integrity in the living human brain through diffusion-water exchange imaging is challenging due to requirements for a high signal-to-noise ratio and short diffusion times dictated by relatively…
View article: In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis
In vivo evidence for cell body loss in cortical lesions in people with multiple sclerosis Open
Objective To quantify alterations in soma and neurite density imaging measures within and surrounding cortical lesions in people with multiple sclerosis using in vivo high‐gradient diffusion MRI. Methods In this cross‐sectional study, 41 p…
View article: PRIME: Phase Reversed Interleaved Multi-Echo acquisition enables highly accelerated distortion-free diffusion MRI
PRIME: Phase Reversed Interleaved Multi-Echo acquisition enables highly accelerated distortion-free diffusion MRI Open
Motivation: Current distortion-free multishot diffusion MRI (dMRI) techniques rely on interim reconstructions to estimate a fieldmap, whose quality deteriorates at high accelerations, thus precluding high-resolution imaging. Goal(s): To de…
View article: Romer‐<scp>EPTI</scp>: Rotating‐view motion‐robust super‐resolution <scp>EPTI</scp> for <scp>SNR</scp>‐efficient distortion‐free in‐vivo mesoscale <scp>diffusion MRI</scp> and microstructure imaging
Romer‐<span>EPTI</span>: Rotating‐view motion‐robust super‐resolution <span>EPTI</span> for <span>SNR</span>‐efficient distortion‐free in‐vivo mesoscale <span>diffusion MRI</span> and microstructure imaging Open
Purpose To overcome the major challenges in diffusion MRI (dMRI) acquisition, including limited SNR, distortion/blurring, and susceptibility to motion artifacts. Theory and Methods A novel Romer‐EPTI technique is developed to achieve SNR‐e…
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the Article Age‐related alterations in human cortical microstructure across the lifespan: Insights from high‐gradient diffusion MRI by Hansol Lee et al., https://doi.org/10.1111/acel.14267 [Image: …