Susumu Ishida
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View article: Lacrimal gland pleomorphic adenoma: two referral center analyses in Hokkaido, Japan
Lacrimal gland pleomorphic adenoma: two referral center analyses in Hokkaido, Japan Open
AIM: To evaluate the clinical features of primary lacrimal gland pleomorphic adenoma (LGPA). METHODS: This was a 2-center, retrospective, observational study of primary LGPA patients who underwent tumor resection. Ophthalmic examinations a…
View article: Correction: New targets in diabetic retinopathy: addressing limitations of current treatments through the Sema3A/Nrp1 pathway
Correction: New targets in diabetic retinopathy: addressing limitations of current treatments through the Sema3A/Nrp1 pathway Open
View article: Unmasking Photophobia and Blepharospasm Mechanisms: The Role of Optic Chiasm and Trigeminal Nerve Compression in a Giant Pituitary Adenoma Case
Unmasking Photophobia and Blepharospasm Mechanisms: The Role of Optic Chiasm and Trigeminal Nerve Compression in a Giant Pituitary Adenoma Case Open
View article: Severe Aqueous-Deficient Dry Eye Following Herpes Zoster Ophthalmicus With Periocular Inflammation: A Case Series
Severe Aqueous-Deficient Dry Eye Following Herpes Zoster Ophthalmicus With Periocular Inflammation: A Case Series Open
View article: A case of IgG4-related ophthalmic disease with bone destruction presenting as unilateral painful blepharitis
A case of IgG4-related ophthalmic disease with bone destruction presenting as unilateral painful blepharitis Open
View article: New targets in diabetic retinopathy: addressing limitations of current treatments through the Sema3A/Nrp1 pathway
New targets in diabetic retinopathy: addressing limitations of current treatments through the Sema3A/Nrp1 pathway Open
Diabetic retinopathy (DR) is a leading cause of acquired blindness. Retinal non-perfusion (RNP) is associated with DR worsening and vision loss. There are no treatments available that specifically address RNP in DR. The semaphorin 3A (Sema…
View article: Morphological Changes in the Saw-Tooth Pattern of Cuticular Drusen Associated with Immune Complex-Mediated Membranous Proliferative Glomerulonephritis Type III: A Case Report
Morphological Changes in the Saw-Tooth Pattern of Cuticular Drusen Associated with Immune Complex-Mediated Membranous Proliferative Glomerulonephritis Type III: A Case Report Open
Introduction: Patients with membranoproliferative glomerulonephritis (MPGN) type III may exhibit the saw-tooth pattern of cuticular drusen. This study reports a four-and-a-half-year retrospective time-dependent observation of cuticular dru…
View article: Inter-Relationships Between the Deep Learning-Based Pachychoroid Index and Clinical Features Associated with Neovascular Age-Related Macular Degeneration
Inter-Relationships Between the Deep Learning-Based Pachychoroid Index and Clinical Features Associated with Neovascular Age-Related Macular Degeneration Open
Background/Objectives: To investigate the impact of pachychoroid on the clinical features of neovascular age-related macular degeneration (nAMD) in Japan using the deep learning-based Hokkaido University pachychoroid index (HUPI), which ha…
View article: Aggressive Orbital Dedifferentiated Liposarcoma With Osseus Components in a Young Woman
Aggressive Orbital Dedifferentiated Liposarcoma With Osseus Components in a Young Woman Open
Background/Aim: Dedifferentiated liposarcoma (DDLS) is a rare but aggressive subtype of liposarcoma that arises in soft tissues. In orbital liposarcoma, malignant transformation from well-differentiated to DDLS typically takes at least a y…
View article: Choroidal blood flow velocity and resistance in inferior posterior staphyloma using a novel superpixel technique in laser speckle flowgraphy
Choroidal blood flow velocity and resistance in inferior posterior staphyloma using a novel superpixel technique in laser speckle flowgraphy Open
View article: When ocular surface treatment fails: exploring neuropathic ocular pain in aqueous-deficient dry eye due to Sjögren’s syndrome treated with mirogabalin: a case study
When ocular surface treatment fails: exploring neuropathic ocular pain in aqueous-deficient dry eye due to Sjögren’s syndrome treated with mirogabalin: a case study Open
Dry eye disease can be classified as aqueous-deficient, evaporative and mixed-type. Recently, neuropathic pain has been indicated to be involved in the subjective symptoms of aqueous-deficient dry eye. However, the mechanism underlying neu…
View article: Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation
Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation Open
Purpose: The Spontaneously Diabetic Torii (SDT) fatty rat is an animal model of obese Type 2 diabetes. We previously reported that the SDT fatty rats develop diabetic cataracts. This study aimed to elucidate early diabetic changes in the r…
View article: A case of uveoscleral mucosa-associated lymphoid tissue lymphoma with secondary angle-closure glaucoma
A case of uveoscleral mucosa-associated lymphoid tissue lymphoma with secondary angle-closure glaucoma Open
Angle-closure glaucoma caused by the uveoscleral MALT lymphoma was treated with radiotherapy, leading to IOP normalization as well as tumor remission.
View article: A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology
A Case of Metastatic Iris Tumor from Adenocarcinoma of the Cecum Diagnosed by Combined Tumor Markers in Aqueous Humor and Fine Needle Aspiration Cytology Open
Introduction: The diagnosis of metastatic iris tumor is made by a fine-needle aspiration biopsy of part of the solid component of the tumor and tumor cells seeded in the anterior chamber; however, sometimes the diagnosis is not made due to…
View article: Acute acquired comitant esotropia associated with Lhermitte–Duclos disease: a case report
Acute acquired comitant esotropia associated with Lhermitte–Duclos disease: a case report Open
View article: Giant conjunctival melanoma with rich vascularization causing persistent bleeding
Giant conjunctival melanoma with rich vascularization causing persistent bleeding Open
The present study reported a rare case of persistent bleeding caused by conjunctival melanoma containing abundant vascular channels. A 44-year-old Japanese woman presented with a left upper eyelid nodule in February 2023. A pigmented conju…
View article: A case of choroidal melanocytoma treated by transscleral resection: A clinicopathological study
A case of choroidal melanocytoma treated by transscleral resection: A clinicopathological study Open
Local resection was useful as a diagnostic treatment for choroidal tumors confined to the periphery of the fundus that were difficult to clinically differentiate from malignant melanoma.
View article: Effects of age and axial length on choroidal stratified structure in normal eyes
Effects of age and axial length on choroidal stratified structure in normal eyes Open
View article: Rationale and Design of VOYAGER: Long-term Outcomes of Faricimab and Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Clinical Practice
Rationale and Design of VOYAGER: Long-term Outcomes of Faricimab and Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema in Clinical Practice Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Clinicopathological findings in refractory diabetic macular edema: A case report
Clinicopathological findings in refractory diabetic macular edema: A case report Open
The present study describes the case of a patient with refractory diabetic cystoid macular edema who underwent vitrectomy with en bloc removal of the cystoid lesion component. The current study also performed histopathological and i…
View article: Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis
Involvement of Angiopoietin 2 and vascular endothelial growth factor in uveitis Open
Purpose Angiopoietin (Ang) 2 is released from vascular endothelial cells by the stimulation of vascular endothelial growth factor (VEGF)A. Ang2 increases the expression of leukocyte adhesion molecules on endothelial cells via nuclear facto…
View article: A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis
A case of tubulointerstitial nephritis and uveitis syndrome accompanied by subclinical choroiditis Open
View article: Alterations in choroidal circulatory dynamics and choroidal thickness before and after treatment in posterior scleritis
Alterations in choroidal circulatory dynamics and choroidal thickness before and after treatment in posterior scleritis Open
Background Posterior scleritis is an inflammatory reaction of the sclera that occurs posterior to the ora serrata. The aim of this study was to present a case of posterior scleritis and to analyze choroidal circulatory and structural chang…
View article: Efficacy, Durability, and Safety of Faricimab in Patients From Asian Countries With Diabetic Macular Edema: 1-Year Subgroup Analysis of the Phase III YOSEMITE and RHINE Trials
Efficacy, Durability, and Safety of Faricimab in Patients From Asian Countries With Diabetic Macular Edema: 1-Year Subgroup Analysis of the Phase III YOSEMITE and RHINE Trials Open
Vision, durability, anatomic, and safety outcomes were generally similar between the Asian and non-Asian country subgroups, suggesting that global YOSEMITE/RHINE results may be generalized to the Asian population. These data support the be…
View article: Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation
Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation Open
The Ser59 phosphorylation of αB-crystallin was modulated by IL-1β in Müller cells under diabetic mimicking inflammatory conditions, suggesting that αB-crystallin contributes to the pathogenesis of PDR through an anti-apoptotic effect.
View article: Alterations of choroidal circulation and choroidal thickness before and after chemoradiotherapy in a case of metastatic choroidal tumor
Alterations of choroidal circulation and choroidal thickness before and after chemoradiotherapy in a case of metastatic choroidal tumor Open
View article: Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats
Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats Open
Mirogabalin suppressed DED-induced hyperalgesia and chronic ocular pain in a rat DED model. Our findings suggested that mirogabalin might effectively alleviate chronic ocular pain in patients with DED.
View article: A case of APMPPE-like panuveitis presenting with extensive outer retinal layer impairment following COVID-19 vaccination
A case of APMPPE-like panuveitis presenting with extensive outer retinal layer impairment following COVID-19 vaccination Open
Background Vaccination against the worldwide pandemic coronavirus disease 2019 (COVID-19) is underway; however, some cases of new onset uveitis after vaccination have been reported. We report a case of bilateral acute posterior multifocal …
View article: A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy
A case of choroidal melanocytosis observed by multimodal imaging with laser speckle flowgraphy Open
View article: Conjunctival cyst with apocrine hidrocystoma-like features: a case report
Conjunctival cyst with apocrine hidrocystoma-like features: a case report Open