Ahmad Faried
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View article: Disability and quality of life in traumatic brain injury in Indonesia a prospective analysis of GCS scores, clinical and social factors in a 5-year cohort study
Disability and quality of life in traumatic brain injury in Indonesia a prospective analysis of GCS scores, clinical and social factors in a 5-year cohort study Open
Background Traumatic brain injury (TBI) remains a major health concern in Indonesia, where the burden is strongly associated with motorcycle-related traffic accidents, limited neurocritical care facilities, and unequal access to rehabilita…
View article: Diagnostic performance of coronary artery disease prediction model (CAD-score system) based on phonocardiogram: a systematic review and meta-analysis
Diagnostic performance of coronary artery disease prediction model (CAD-score system) based on phonocardiogram: a systematic review and meta-analysis Open
Introduction Pre-test probability stratification of individuals with suspected obstructive coronary artery disease (CAD) has remained suboptimal for many years. Consequently, the majority of diagnostic tests used to rule out CAD exhibit no…
View article: Potential of Secretome Hydrogel for Wound Healing in LPS- and Scratch-Induced BJ Cells as an Inflammation Model
Potential of Secretome Hydrogel for Wound Healing in LPS- and Scratch-Induced BJ Cells as an Inflammation Model Open
Wound healing often requires specialized interventions to accelerate recovery due to prolonged inflammation and limited regenerative factors. Umbilical Cord Mesenchymal Stem Cells secretome (UCMSCs) comprises various cytokines and growth f…
View article: Mesenchymal Stem Cells as Anti-Inflammatory Agents in Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Mesenchymal Stem Cells as Anti-Inflammatory Agents in Chronic Kidney Disease: A Systematic Review and Meta-Analysis Open
Background: Chronic kidney disease (CKD) is largely driven by inflammation. Mesenchymal stem cells (MSCs) show therapeutic potential; however, their efficacy across CKD etiologies remains unclear. Methods: Comprehensive searches were condu…
View article: Correlation of Nutritional Status, HbA1c, and Duration of Diabetes Mellitus with Amputation Incidence in Patients with Diabetic Foot Ulcers
Correlation of Nutritional Status, HbA1c, and Duration of Diabetes Mellitus with Amputation Incidence in Patients with Diabetic Foot Ulcers Open
Diabetic foot ulcer (DFU) is a severe complication of diabetes that significantly impairs quality of life and may often lead to amputation, particularly when infections become extensive. This study investigated the correlation of nutrition…
View article: Exploring nano curcumin as a potential therapeutic alternative for glioblastoma multiforme via downregulation of growth factors and induction of apoptosis
Exploring nano curcumin as a potential therapeutic alternative for glioblastoma multiforme via downregulation of growth factors and induction of apoptosis Open
Glioma is a type of brain tumor that start from neuroglial stem cells. Despite advancements in surgery and additional adjuvant therapy such as Temozolomide (TMZ), treating this tumor continues to present a challenge with notable side effec…
View article: Transverse myelitis successfully treated with posterior decompression followed by secretome and mesenchymal stem cell therapy
Transverse myelitis successfully treated with posterior decompression followed by secretome and mesenchymal stem cell therapy Open
Introduction: Transverse myelitis (TM) is a rare spinal cord disorder caused by inflammation. Usually, this occurs as a complication of infection or autoimmune disease; however, idiopathic causes such as vaccinations have been reported. Th…
View article: In vitro and In vivo Studies on Mesenchymal Stem Cells for Ischemic Stroke Therapy: A Scoping Review of The Therapeutic Effect
In vitro and In vivo Studies on Mesenchymal Stem Cells for Ischemic Stroke Therapy: A Scoping Review of The Therapeutic Effect Open
MSC and secretome therapy for stroke have shown promising results in both in vitro and in vivo models. Exploration of alternative MSC sources, refining of isolation techniques, transfection of various proteins, and combination with herbal …
View article: Poor diagnostic value of isocitrate dehydrogenase 1 R132H immunohistochemistry for determination of isocitrate dehydrogenase 1 status in patients with glioblastoma
Poor diagnostic value of isocitrate dehydrogenase 1 R132H immunohistochemistry for determination of isocitrate dehydrogenase 1 status in patients with glioblastoma Open
Background The World Health Organization (WHO) classification of central nervous system (CNS) tumors is a major advance toward improving the diagnosis of adult brain tumors. Despite the promise of isocitrate dehydrogenase (IDH) mutations a…
View article: Traumatic axonal injury successfully treated with secretome followed by mesenchymal stem cells therapy
Traumatic axonal injury successfully treated with secretome followed by mesenchymal stem cells therapy Open
Introduction: Traumatic axonal injury (TAI), a head injury condition formerly known as diffuse axonal injury, results from direct mechanical forces causing multiple scattered lesions, either haemorrhagic or non-haemorrhagic, within brain t…
View article: Gene expression profiles of angiogenesis markers and microRNA-128 from the secretome of umbilical cord mesenchymal stem cells from Macaca fascicularis
Gene expression profiles of angiogenesis markers and microRNA-128 from the secretome of umbilical cord mesenchymal stem cells from Macaca fascicularis Open
Background and Aim: Angiogenesis and anti-apoptosis play crucial roles in ischemic stroke recovery. The mesenchymal stem cell (MSC) secretome, rich in bioactive molecules, presents a promising therapeutic avenue. However, optimizing the cu…
View article: Serum taurine level versus endocan as potential biomarkers for early diagnosis of ischemic diabetic foot in type 2 diabetic patients
Serum taurine level versus endocan as potential biomarkers for early diagnosis of ischemic diabetic foot in type 2 diabetic patients Open
Objective: Our goal is to break the vicious cycle between diabetes and its critical complications by measuring two potential biomarkers (Endocan and Taurine) that are used as pre-diagnostic markers of diabetic complications (ischemic diabe…
View article: Innovating Glioma Therapy Using Secretions from Umbilical Cord Mesenchymal Stem Cells to Target Homeobox and Growth Factor Genes
Innovating Glioma Therapy Using Secretions from Umbilical Cord Mesenchymal Stem Cells to Target Homeobox and Growth Factor Genes Open
Background: Glioblastoma is a prevalent and challenging malignant brain tumor. Secretome therapy using human umbilical cord mesenchymal stem cells (hUCMSCs) appears to be a promising treatment for glioblastoma. This study analyzed the pote…
View article: Successful management of interdural spinal cysts presenting as radiculopathy caused by epidural venous enlargement: illustrative case
Successful management of interdural spinal cysts presenting as radiculopathy caused by epidural venous enlargement: illustrative case Open
BACKGROUND The authors report the first case of thoracic interdural spinal cysts presenting as radiculopathy attributed to overdrainage-related cervical venous plexus enlargement. This case emphasizes the importance of considering interdur…
View article: <b><i>In vitro</i> model of ischemic stroke neurons from <i>Macaca fascicularis</i></b>
<b><i>In vitro</i> model of ischemic stroke neurons from <i>Macaca fascicularis</i></b> Open
Background: Primary cells have the same heterogeneity and differentiation capacity that has potential as an in vitro ischemic stroke models. It is hoped that primary cells from non-human primates/NHPs that have genetic similarities to huma…
View article: Surgical treatment of tuberculum sellae meningioma: A retrospective review of single institutional experience
Surgical treatment of tuberculum sellae meningioma: A retrospective review of single institutional experience Open
Background: Tuberculum sellae meningiomas (TSMs) represent a distinct entity among intracranial meningiomas. Both transcranial approaches (TCAs) and endoscopic endonasal approaches (EEAs) have provided neurosurgeons with options for managi…
View article: Giant scalp dermatofibrosarcoma protuberans at mid-occipital scalp: A rare case report
Giant scalp dermatofibrosarcoma protuberans at mid-occipital scalp: A rare case report Open
Background: Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer that arises in the deeper layers of the skin, most commonly on the trunk and limbs. The presentation of DFSP on the scalp is worth documentation due to its ex…
View article: The Potential of Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Based Topical Gel for Therapeutic Application
The Potential of Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Based Topical Gel for Therapeutic Application Open
Background: Diabetic Foot Ulcer (DFU) might be worsened by neuropathy and vascular issues. This condition can cause 14.3% fatality, stressing the need for effective wound healing therapy. Wound healing is a complex biological process, and …
View article: Mechanical Properties of Macaca fascicularis Amniotic Membrane and Duramater: A Potential Biomaterial for Dural Defect Closure
Mechanical Properties of Macaca fascicularis Amniotic Membrane and Duramater: A Potential Biomaterial for Dural Defect Closure Open
Background: The amniotic membrane (AM), a versatile biomaterial with inherent stem cells and extracellular matrix, has shown promise in various tissue engineering applications. Its potential as a dural substitute, particularly in addressin…
View article: Wound Healing Potent of Lyophilized-Secretome Gel from Human Wharton’s Jelly Mesenchymal Stem Cells
Wound Healing Potent of Lyophilized-Secretome Gel from Human Wharton’s Jelly Mesenchymal Stem Cells Open
Wounds that become infected can lead to serious illness or even death if left untreated. Unfortunately, current wound healing treatments don’t always work well. Achieving optimal wound healing involves the coordination of diverse cellular …
View article: Traumatic Brain Injury and Covid-19
Traumatic Brain Injury and Covid-19 Open
Head trauma is a head injury caused by external forces in the head or body that results in disruption of the normal functioning of the brain. According to the CDC, deaths from head injuries were about 60,000 in 2016, and rose to more than …
View article: The Characteristics of Umbilical Cord Derived Mesenchymal Stem Cell/UCMSC from Macaca fascicularis and Its Secretome Under Hypoxic Conditions
The Characteristics of Umbilical Cord Derived Mesenchymal Stem Cell/UCMSC from Macaca fascicularis and Its Secretome Under Hypoxic Conditions Open
Mesenchymal Stem Cell (MSC) secretome has potential as a neuroprotective and neuroregenerative agent. It can have effects due to its paracrine factors, such as Brain Derived Neurotrophic Factor (BDNF) and Stromal-Cell Derived Factor-1 (SDF…
View article: Case Study: Heterogeneity of and CD44+/CD24- Cancer Stem Cell Subpopulation of Breast Cancer Patients in Bandung, Indonesia
Case Study: Heterogeneity of and CD44+/CD24- Cancer Stem Cell Subpopulation of Breast Cancer Patients in Bandung, Indonesia Open
Breast cancer (BC) cells characteristics have played a crucial role in clinical strategies decision-making and patient outcome prediction. Although there have been several studies examining this, there are still relatively few that analyze…
View article: Isolation and Characterization of Fibroblast from Normal and Thalassemia Foreskin
Isolation and Characterization of Fibroblast from Normal and Thalassemia Foreskin Open
Thalassemia is a genetic blood disorder impacting hemoglobin production, varies in severity, and requires lifelong treatments. The advancement in somatic cell reprogramming through induced pluripotent stem cells (iPSCs) represents a person…
View article: Allogeneic human umbilical cord mesenchymal stem cell secretome effect on apoptosis of HeLa cells
Allogeneic human umbilical cord mesenchymal stem cell secretome effect on apoptosis of HeLa cells Open
Introduction: Cervical cancer treatment typically involves surgery, chemotherapy, and radiotherapy. However, exploring novel treatment approaches is crucial. Stem cell secretome therapy provides new insights as an additional option in the …
View article: Cerebral Tuberculomas Mimicking A Brain Tumor: Report of Two Cases
Cerebral Tuberculomas Mimicking A Brain Tumor: Report of Two Cases Open
Introduction : Cerebral tuberculoma, a seldom encountered and severe manifestation of tuberculosis (TB), arises from the dissemination of Mycobacterium tuberculosis through the bloodstream. Its symptoms and radiological characteristics lac…
View article: Potency of Peripheral Blood- and Umbilical Cord Blood-derived Dendritic Cells and Their Secretomes as Vaccines for Cancer
Potency of Peripheral Blood- and Umbilical Cord Blood-derived Dendritic Cells and Their Secretomes as Vaccines for Cancer Open
Dendritic cell (DC) vaccines, as immunotherapy agents, can gather up and transport cancer-related antigens to T lymphocytes, activating anti-tumor effector responses. After being activated by DC, cytotoxic T lymphocyte cells (CTL) will sec…
View article: Potential antiaging activity of secretome gel of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs) in UV-induced mice models.
Potential antiaging activity of secretome gel of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs) in UV-induced mice models. Open
The secretome gel of hWJ-MSCs showed antiaging activities with potential for preventing and curing skin aging.