Suvarna Alladi
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View article: Impact of vascular risk factor in neurodegenerative dementia: a retrospective study
Impact of vascular risk factor in neurodegenerative dementia: a retrospective study Open
Background The prevalence of dementia is dramatically increasing worldwide. In this context, early diagnosis and identification of presymptomatic individuals at higher risk of developing dementia is crucial. Early interventions through mod…
View article: Early Occupational Therapy intervention to prevent contractures in person with Dementia – A Case Series
Early Occupational Therapy intervention to prevent contractures in person with Dementia – A Case Series Open
Background Joint contractures are very common in persons with dementia who are confined to bed in the terminal stage, which will lead to difficulty in transferring the patients from one place to another, difficulty in maintaining the postu…
View article: Transitional care needs and social factors in post diagnostic support in dementia: A mixed methods study
Transitional care needs and social factors in post diagnostic support in dementia: A mixed methods study Open
Background Ensuring smooth care transitions of is a major challenge in healthcare settings, particularly for persons diagnosed with complex conditions like dementia and their family caregivers having diverse perspectives on the needs and s…
View article: Dementia Home Care in Urban and Rural India: A qualitative exploration
Dementia Home Care in Urban and Rural India: A qualitative exploration Open
Background Dementia home care in urban India faces significant challenges, including social stigma, inadequate resources, lack of knowledge about the resources, lack of help seeking behaviour and caregiver burden. Despite these hurdles, ho…
View article: Digits Across Languages: The Role of Lexical and Numerical Characteristics in Digit Span Performance Across Fourteen Languages
Digits Across Languages: The Role of Lexical and Numerical Characteristics in Digit Span Performance Across Fourteen Languages Open
Background The digit span task, a measure of auditory verbal short‐term and working memory, is widely used globally. Emerging research has revealed variations in digit span performance across languages among young adults; however, studies …
View article: Potential Eligibility for Lecanemab in a Cohort of Alzheimer’s Dementia Patients from India
Potential Eligibility for Lecanemab in a Cohort of Alzheimer’s Dementia Patients from India Open
Background Lecanemab, a monoclonal antibody targeting amyloid, has been approved as disease‐modifying treatment for Alzheimer’s disease (AD) and is gradually gaining regulatory approvals across the globe. However, its accessibility and app…
View article: Correct Information Units in Narrative Discourse as an Indicator of Dementia
Correct Information Units in Narrative Discourse as an Indicator of Dementia Open
Background Correct Information Units (CIUs) are proven quantitative measures to analyze semanticity in the discourse of adults with neurogenic communication disorders, including dementia. Moreover, semantic impairment is often seen in the …
View article: Performance Based Assessment: A unique approach to ecologically valid assessment of cognition
Performance Based Assessment: A unique approach to ecologically valid assessment of cognition Open
Background Impairments in daily activities often signal deficits in cognitive abilities. Existing tests evaluating cognition rely heavily on paper‐pencil formats that favor educated populations. Ecologically valid, person‐centered tests ba…
View article: Profile of People living with Dementia Referred to Neuropalliative Care Clinic at a Tertiary Care Center
Profile of People living with Dementia Referred to Neuropalliative Care Clinic at a Tertiary Care Center Open
Background Dementia is a neurodegenerative condition that progressively impairs cognitive and functional abilities, significantly affecting the quality of life. People living with dementia (PLWD) will benefit from timely referral to Neurop…
View article: “Understanding the impact of sensory loss on elders with cognitive impairment: A qualitative study of family carers’ views on implications for quality of life and care in India”
“Understanding the impact of sensory loss on elders with cognitive impairment: A qualitative study of family carers’ views on implications for quality of life and care in India” Open
Background Impaired vision and hearing (sensory impairment) are common among elders, particularly those with cognitive impairment or dementia. The resulting difficulties with communication, daily functioning and social interactions reduce …
View article: Cognitive Impairment in Autoimmune Encephalitis: Characterization and Predicting Long-term Outcomes
Cognitive Impairment in Autoimmune Encephalitis: Characterization and Predicting Long-term Outcomes Open
Background: Autoimmune encephalitis (AE) is now emerging as an important cause of reversible cognitive impairment. Aims: We aimed to study cognitive domains affected in various subtypes of AE, assess the changes in cognitive profile, and f…
View article: Digital Clock Assessment in South Asian Setting: Pilot study
Digital Clock Assessment in South Asian Setting: Pilot study Open
As cognitive impairment becomes a growing burden in low- and middle-income countries, scalable tools for early detection are urgently needed. This pilot study evaluated the feasibility and performance of a tablet-based digital Clock Drawin…
View article: Multimodal Imaging and Logistic Weighted Cognitive Scores for Classification of MCI, AD, and FTD Subtypes
Multimodal Imaging and Logistic Weighted Cognitive Scores for Classification of MCI, AD, and FTD Subtypes Open
Background Differentiating between mild cognitive impairment (MCI), Alzheimer’s disease (AD), and frontotemporal dementia (FTD) subtypes remains a clinical challenge due to overlapping cognitive symptoms, structural atrophy, and metabolic …
View article: Disease-Modifying Drugs for Alzheimer’s Disease: Bending the Curve
Disease-Modifying Drugs for Alzheimer’s Disease: Bending the Curve Open
Alzheimer’s disease (AD) is the most prevalent form of dementia worldwide and the leading cause of disability in the aging population. While several disease-modifying therapies, particularly anti-amyloid monoclonal antibodies, have recentl…
View article: Clinical profile, atrophy and inheritance patterns of pathogenic MAPT gene mutations in Frontotemporal dementia detected using whole exome sequencing: a single-center first report from India
Clinical profile, atrophy and inheritance patterns of pathogenic MAPT gene mutations in Frontotemporal dementia detected using whole exome sequencing: a single-center first report from India Open
In the Indian context, pathogenic MAPT in FTD is being reported for the first time and notably from a single center by WES. Identifying pathogenic MAPT genes is important in planning mutation-specific clinical trials and understanding ethi…
View article: Identifying target regions for non-invasive brain stimulation of the language network in primary progressive aphasia: A narrative review
Identifying target regions for non-invasive brain stimulation of the language network in primary progressive aphasia: A narrative review Open
Primary progressive aphasia (PPA) is a heterogeneous neurodegenerative condition characterized by loss of language function. The present review discusses that Non-invasive brain stimulation (NIBS) holds the potential to benefit these patie…
View article: A Qualitative Exploration of Caregiving in Advanced Dementia: Caregiver Perspectives on Unmet Needs in Low- and Middle-income Setting
A Qualitative Exploration of Caregiving in Advanced Dementia: Caregiver Perspectives on Unmet Needs in Low- and Middle-income Setting Open
Objectives: The complex and varied needs that people with dementia experience as they approach the advanced stage are context-specific and often unfulfilled. Caregiving is usually family-led and at home, with limited institutional support …
View article: Thalamus as a neural marker of cognitive reserve in bilinguals with frontotemporal dementia
Thalamus as a neural marker of cognitive reserve in bilinguals with frontotemporal dementia Open
Bilingualism delays the onset of dementia symptoms and contributes to cognitive reserve. However, the neural basis of this mechanism remains elusive. The few studies that have investigated neural mechanisms of cognitive reserve and bilingu…
View article: Subacute Sclerosing Panencephalitis: A Case Report of Atypical Long-Term Survivor
Subacute Sclerosing Panencephalitis: A Case Report of Atypical Long-Term Survivor Open
Subacute sclerosing pan encephalitis (SSPE) is a slow viral disease that follows the wild-type measles infection of early childhood with a subsequent progressive encephalitic illness with seizures and global regression after a long latent …
View article: Diagnostic value of fluid‐based non‐amyloid biomarkers for Alzheimer's disease and related dementias in a clinic‐based cohort from South Asia
Diagnostic value of fluid‐based non‐amyloid biomarkers for Alzheimer's disease and related dementias in a clinic‐based cohort from South Asia Open
INTRODUCTION The rising dementia burden and limited knowledge of fluid biomarkers in South Asians highlights this study's aim on evaluating their utility for the diagnosis of Alzheimer's disease and related dementias (ADRD). METHODS Partic…
View article: Cognitive Level Enhancement through Vision Exams and Refraction (CLEVER): study protocol for a randomised controlled trial
Cognitive Level Enhancement through Vision Exams and Refraction (CLEVER): study protocol for a randomised controlled trial Open
Background Longitudinal observational studies have found an association between vision impairment and accelerated decline in cognition. However, no randomised trials have assessed the possible benefit of vision correction on cognitive chan…
View article: On the feasibility of an online brain-computer interface-based neurofeedback game for enhancing attention and working memory in stroke and mild cognitive impairment patients
On the feasibility of an online brain-computer interface-based neurofeedback game for enhancing attention and working memory in stroke and mild cognitive impairment patients Open
Background . Neurofeedback training (NFT) using Electroencephalogram-based Brain Computer Interface (EEG-BCI) is an emerging therapeutic tool for enhancing cognition. Methods . We developed an EEG-BCI-based NFT game for enhancing attention…
View article: Satisfaction With Teleneurology in Low Resource Setting: A Cross-Sectional Study Among Patients and Healthcare Providers
Satisfaction With Teleneurology in Low Resource Setting: A Cross-Sectional Study Among Patients and Healthcare Providers Open
Background and Objectives Teleneurology has become instrumental in extending neurologic care in remote and underserved areas, enhancing access, and potentially improving patient outcomes while reducing costs. This study evaluates the satis…
View article: Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study
Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study Open
A network neuroscience perspective can significantly advance the understanding of neurodegenerative disorders, particularly frontotemporal dementia (FTD). This study employed an innovative multiplex connectomics approach, integrating corti…
View article: Evaluating the potential of teleneurology in a low‐resource setting for dementia: An exploratory study on patient and healthcare provider satisfaction
Evaluating the potential of teleneurology in a low‐resource setting for dementia: An exploratory study on patient and healthcare provider satisfaction Open
Background and Objectives Telemedicine, including teleneurology, has emerged as a valuable tool for providing healthcare services remotely, particularly in situations where distance plays a critical role. Teleneurology has the potential to…
View article: Bilingualism and education may have distinct reserve/resilience trajectories: Evidence from white matter changes
Bilingualism and education may have distinct reserve/resilience trajectories: Evidence from white matter changes Open
Background Bilingualism and education have been known to enhance reserve/resilience through white matter (WM) microstructural changes. Reserve/resilience is the ability of the brain to cope with neurocognitive adversities. Two key hypothes…
View article: Digital version of Defense Automated Neurobehavioral Assessment in South Asian Setting: Preliminary evidence from the P‐CARRS study
Digital version of Defense Automated Neurobehavioral Assessment in South Asian Setting: Preliminary evidence from the P‐CARRS study Open
Background The Defense Automated Neurobehavioral Assessment (DANA) encompasses a suite of standardized neurocognitive screening tools designed for detecting various neurodegenerative diseases and subtle cognitive deficits. This study prese…