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View article: ELN milestone-driven TKI switching improves deep molecular response rates in chronic myeloid leukemia
ELN milestone-driven TKI switching improves deep molecular response rates in chronic myeloid leukemia Open
Background: Deep molecular response (DMR) is a prerequisite for successful treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) on tyrosine kinase inhibitor (TKI) therapy. Achievement of an opt…
View article: Causal Effects of AL Amyloidosis on Autoimmune Diseases and the Role of Inflammatory Cytokines: Insights from Mendelian Randomization
Causal Effects of AL Amyloidosis on Autoimmune Diseases and the Role of Inflammatory Cytokines: Insights from Mendelian Randomization Open
Background This study aims to investigate the causal effect of amyloid light-chain (AL) amyloidosis on autoimmune diseases (ADs), with a focus on identifying inflammatory cytokines as potential mediators from a genetic perspective. Methods…
View article: DEPANet: A Differentiable Edge-Guided Pyramid Aggregation Network for Strip Steel Surface Defect Segmentation
DEPANet: A Differentiable Edge-Guided Pyramid Aggregation Network for Strip Steel Surface Defect Segmentation Open
The steel strip is an important and ideal material for the automotive and aerospace industries due to its superior machinability, cost efficiency, and flexibility. However, surface defects such as inclusions, spots, and scratches can signi…
View article: Prediction and validation of anoikis-related genes in neuropathic pain using machine learning
Prediction and validation of anoikis-related genes in neuropathic pain using machine learning Open
Background Neuropathic pain (NP) can be induced by a variety of clinical conditions, such as spinal cord injury, lumbar disc herniation (LDH), lumbar spinal stenosis, diabetes, herpes zoster, and spinal cord tumors, and inflammatory stimul…
View article: A Strip Steel Surface Defect Salient Object Detection Based on Channel, Spatial and Self-Attention Mechanisms
A Strip Steel Surface Defect Salient Object Detection Based on Channel, Spatial and Self-Attention Mechanisms Open
Strip steel is extensively utilized in industries such as automotive manufacturing and aerospace due to its superior machinability, economic benefits, and adaptability. However, defects on the surface of steel strips, such as inclusions, p…
View article: Comprehensive analysis of human monocyte subsets using full-spectrum flow cytometry and hierarchical marker clustering
Comprehensive analysis of human monocyte subsets using full-spectrum flow cytometry and hierarchical marker clustering Open
Introduction Exploring monocytes’ roles within the tumor microenvironment is crucial for crafting targeted cancer treatments. Methods This study unveils a novel methodology utilizing four 20-color flow cytometry panels for comprehensive pe…
View article: Outcomes of intermediate or high‐risk CMML patients treated with hypomethylating agents combined with venetoclax: A single center experience
Outcomes of intermediate or high‐risk CMML patients treated with hypomethylating agents combined with venetoclax: A single center experience Open
Chronic myelomonocytic leukemia (CMML) treatment remains a pressing clinical challenge. We conducted a retrospective analysis on 52 CMML cases, exploring the effectiveness of combining venetoclax (Vene) with hypomethylating agents (HMAs). …
View article: Diagnostic and prognostic value of ferroptosis-related genes in patients with Myelodysplastic neoplasms
Diagnostic and prognostic value of ferroptosis-related genes in patients with Myelodysplastic neoplasms Open
This study delves into the emerging role of ferroptosis in Myelodysplastic Neoplasms (MDS) and aims to identify a prognostic ferroptosis-related gene signature for MDS. Utilizing RNA-seq data and clinical information from the Gene Expressi…
View article: Stem cell-based therapy for COVID-19
Stem cell-based therapy for COVID-19 Open
While The World Health Organization (WHO) has announced that COVID-19 is no longer a public health emergency of international concern(PHEIC), the risk of reinfection and new emerging variants still makes it crucial to study and work toward…
View article: Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway Open
View article: Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated <scp>WNT</scp>/β‐catenin signalling by parallel <scp>RNA</scp> sequencing and dysfunctional phenotypes
Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated <span>WNT</span>/β‐catenin signalling by parallel <span>RNA</span> sequencing and dysfunctional phenotypes Open
British Journal of HaematologyEarly View ERRATUMFree Access Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated WNT/β-catenin signalling by parallel RNA sequencing and dysfunctional phenotyp…
View article: Multi-omics reveals azacitidine partially restores the hematopoiesis-supportive functions in mesenchymal stromal cells from patients with chronic myelomonocytic leukemia
Multi-omics reveals azacitidine partially restores the hematopoiesis-supportive functions in mesenchymal stromal cells from patients with chronic myelomonocytic leukemia Open
Hypomethylating agents (HMAs) including azacitidine (AZA) represent the only FDA-approved first-line treatments for patients with chronic myelomonocytic leukemia (CMML). However, the mechanism by which HMAs produce therapeutic responses (e…
View article: Diagnostic and prognostic value of ferroptosis-related genes in patients with Myelodysplastic neoplasms
Diagnostic and prognostic value of ferroptosis-related genes in patients with Myelodysplastic neoplasms Open
This study delves into the emerging role of ferroptosis in Myelodysplastic Neoplasms (MDS) and aims to identify a prognostic ferroptosis-related gene signature for MDS. Utilizing RNA-seq data and clinical information from the Gene Expressi…
View article: Deep learning-based transcriptome model predicts survival of T-cell acute lymphoblastic leukemia
Deep learning-based transcriptome model predicts survival of T-cell acute lymphoblastic leukemia Open
Identifying subgroups of T-cell acute lymphoblastic leukemia (T-ALL) with poor survival will significantly influence patient treatment options and improve patient survival expectations. Current efforts to predict T-ALL survival expectation…
View article: The Gut Bacteria Dysbiosis Contributes to Chronic Graft-Versus-Host Disease Associated With a Treg/Th1 Ratio Imbalance
The Gut Bacteria Dysbiosis Contributes to Chronic Graft-Versus-Host Disease Associated With a Treg/Th1 Ratio Imbalance Open
Introduction Dysbiosis of gut bacteria has been discovered in a large number of autoimmune diseases. However, the influence of the gut bacteria in the mice model of chronic sclerodermatous graft-versus-host disease (Scl-GVHD), a disease th…
View article: Dynamics of PD-1 expression are associated with treatment efficacy and prognosis in patients with intermediate/high-risk myelodysplastic syndromes under hypomethylating treatment
Dynamics of PD-1 expression are associated with treatment efficacy and prognosis in patients with intermediate/high-risk myelodysplastic syndromes under hypomethylating treatment Open
Hypomethylating agents (HMAs) are widely used in patients with higher-risk MDS not eligible for stem cell transplantation. However, the general response rate by HMAs is lesser than 50% in MDS patients, while the relapse rate is high. Emerg…
View article: C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction
C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction Open
View article: Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia
Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia Open
Background: Emerging evidence has proven that ferroptosis plays an important role in the development of acute myeloid leukemia (AML), whereas the exact role of ferroptosis-associated genes in AML patients’ prognosis remained unclear. Mater…
View article: Lower BCL11B expression is associated with adverse clinical outcome for patients with myelodysplastic syndrome
Lower BCL11B expression is associated with adverse clinical outcome for patients with myelodysplastic syndrome Open
Myelodysplastic syndrome (MDS) is an aggressive and genetically heterogeneous disease with poor prognosis. Cellular immune disorder is a common characteristic of this disease and is thought to be related to clinical outcome. Alterations in…
View article: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: overactivated WNT/β‐catenin signalling by parallel RNA sequencing and dysfunctional phenotypes
Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: overactivated WNT/β‐catenin signalling by parallel RNA sequencing and dysfunctional phenotypes Open
Summary Sophisticated cross‐talk between bone marrow mesenchymal stromal cells (BM MSCs) and haematopoietic/leukaemic stem cells in patients with myelodysplastic syndromes (MDS) and myeloid leukaemia have been emphasized in previous report…
View article: Decitabine With or Without Micro-Transplantation for the Treatment of Intermediate or High-Risk Myelodysplastic Syndrome: A Chinese Single-Center Retrospective Study of 22 Patients
Decitabine With or Without Micro-Transplantation for the Treatment of Intermediate or High-Risk Myelodysplastic Syndrome: A Chinese Single-Center Retrospective Study of 22 Patients Open
The treatment outcomes of intermediate or high-risk myelodysplastic syndrome (MDS) remain unsatisfactory. This study was designed to evaluate the safety and efficacy of human leukocyte antigen (HLA)-mismatched hematopoietic stem cell micro…
View article: Hypomethylating agents in the treatment of chronic myelomonocytic leukemia: a meta-analysis and systematic review
Hypomethylating agents in the treatment of chronic myelomonocytic leukemia: a meta-analysis and systematic review Open
This current study may provide preliminary data in evaluating the efficacy and safety of HMAs in patients with CMML. Decitabine and azacitidine are comparable effective and safe in treating CMML. However, it is necessary to point out that …
View article: Concurrence of Myelodysplastic syndromes and large granular lymphocyte leukemia: clinicopathological features, mutational profile and gene ontology analysis in a single center.
Concurrence of Myelodysplastic syndromes and large granular lymphocyte leukemia: clinicopathological features, mutational profile and gene ontology analysis in a single center. Open
The concurrence of Myelodysplastic syndromes (MDS) and large granular lymphocyte leukemia (LGLL) has been reported in a small group of patients and might suggest an etiologic relationship rather than a simple coincidence. In this present s…
View article: C‐Type Lectin‐Like Molecule‐1 as a Biomarker for Diagnosis and Prognosis in Acute Myeloid Leukemia: A Preliminary Study
C‐Type Lectin‐Like Molecule‐1 as a Biomarker for Diagnosis and Prognosis in Acute Myeloid Leukemia: A Preliminary Study Open
Objective . AML is a heterogeneous disease both in genomic and proteomic backgrounds, and variable outcomes may appear in the same cytogenetic risk group. Therefore, it is still necessary to identify new antigens that contribute to diagnos…
View article: Methotrexate (MTX) Plus Hydroxychloroquine versus MTX Plus Leflunomide in Patients with MTX-Resistant Active Rheumatoid Arthritis: A 2-Year Cohort Study in Real World
Methotrexate (MTX) Plus Hydroxychloroquine versus MTX Plus Leflunomide in Patients with MTX-Resistant Active Rheumatoid Arthritis: A 2-Year Cohort Study in Real World Open
Le Zhang,1,2,* Fangfang Chen,2,* Shikai Geng,2,* Xiaodong Wang,2 Liyang Gu,2 Yitian Lang,1 Ting Li,2 Shuang Ye2 1Department of Pharmacy, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republi…
View article: Correction to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia
Correction to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia Open
View article: [An interlaboratory comparison study on the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels].
[An interlaboratory comparison study on the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels]. Open
Objective: To investigate the current status and real performance of the detection of RUNX1-RUNX1T1 fusion transcript levels and WT1 transcript levels in China through interlaboratory comparison. Methods: Peking University Pe…
View article: Phenotype of mesenchymal stem cells from patients with myelodyplastic syndrome maybe partly modulated by decitabine
Phenotype of mesenchymal stem cells from patients with myelodyplastic syndrome maybe partly modulated by decitabine Open
Mesenchymal stem cells (MSCs) derived from myelodysplastic syndromes (MDSs) have been demonstrated to accelerate the progression of MDS. However, whether the phenotype of MSCs derived from MDS (MDS-MSCs) may be reversed and serve as a pote…
View article: [Changes of WT1 mRNA expression level in patients with myelodysplastic syndromes after hypomethylating agents and its prognostic significance].
[Changes of WT1 mRNA expression level in patients with myelodysplastic syndromes after hypomethylating agents and its prognostic significance]. Open
Objective: To monitor the WT1 mRNA level and its dynamic changes in patients with myelodysplastic syndromes (MDS) after hypomethylating agents (HMA) , as well as to assess the significance of WT1 mRNA levels and its dynamic changes …
View article: Co-occurrence of RUNX1 and ASXL1 mutations underlie poor response and outcome for MDS patients treated with HMAs.
Co-occurrence of RUNX1 and ASXL1 mutations underlie poor response and outcome for MDS patients treated with HMAs. Open
The molecular determinants of the clinical response to Hypomethylating agents (HMAs) in patients with myelodysplastic syndromes (MDS) are unclear. We analyzed 84 adult patients with MDS who received hypomethylating agents (HMAs) and identi…