Suyi Luo
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View article: Inhibition of Advanced Glycation End Products: A Nexus of Chicken Hyperglycemia and Inflammation Absence
Inhibition of Advanced Glycation End Products: A Nexus of Chicken Hyperglycemia and Inflammation Absence Open
Poultry have higher blood glucose concentrations, which are 1.5–2 times those of their mammalian counterparts with equivalent body mass, yet do not show any adverse effects. However, the underlying mediators that inhibit systemic inflammat…
View article: Huang-Lian-Jie-Du-Decoction alleviates atherosclerotic plaque and lipid profile in HFD-induced ApoE-/- mice involve the gut microbiota-mediated TMA/FMO3/TMAO axis
Huang-Lian-Jie-Du-Decoction alleviates atherosclerotic plaque and lipid profile in HFD-induced ApoE-/- mice involve the gut microbiota-mediated TMA/FMO3/TMAO axis Open
Huang-Lian-Jie-Du-Decoction (HLJDD), a classic traditional Chinese medicine formula, is commonly used clinically to improve atherosclerosis (AS). Previous studies have primarily focused on the mechanisms of action of its blood-absorbed com…
View article: PHB1 and PHB2 positively regulate IFN-β production by targeting MAVS in ducks
PHB1 and PHB2 positively regulate IFN-β production by targeting MAVS in ducks Open
View article: Serum uric acid to serum creatinine ratio and gallstones risk: Analysis from the National Health and Nutrition Examination Survey (2017–2020)
Serum uric acid to serum creatinine ratio and gallstones risk: Analysis from the National Health and Nutrition Examination Survey (2017–2020) Open
Background Insulin resistance and metabolic syndrome had a significant impact on the development of gallstones. This study investigated the relationship between gallstone patients in the United States and the serum uric acid to serum creat…
View article: Association fasting blood sugar to high-density lipoprotein cholesterol ratio and hypertension: Analysis from the National Health and Nutrition Examination Survey (2003– 2018)
Association fasting blood sugar to high-density lipoprotein cholesterol ratio and hypertension: Analysis from the National Health and Nutrition Examination Survey (2003– 2018) Open
Hypertension is a chronic disease that poses a significant threat to human health worldwide. The ratio of fasting blood sugar to high-density lipoprotein cholesterol (GHR) is an emerging biomarker associated with various diseases. However,…
View article: Time‐course transcriptome and chromatin accessibility analyses reveal the dynamic transcriptional regulation shaping spikelet hull size
Time‐course transcriptome and chromatin accessibility analyses reveal the dynamic transcriptional regulation shaping spikelet hull size Open
SUMMARY The grains of rice ( Oryza sativa ) are enclosed by a spikelet hull comprising the lemma and palea. Development of the spikelet hull determines the storage capacity of the grain, thus affecting grain yield and quality. Although mul…
View article: Advances in Virus Biorecognition and Detection Techniques for the Surveillance and Prevention of Infectious Diseases
Advances in Virus Biorecognition and Detection Techniques for the Surveillance and Prevention of Infectious Diseases Open
Viral infectious diseases pose a serious threat to global public health due to their high transmissibility, rapid mutation rates, and limited treatment options. Recent outbreaks of diseases such as plague, monkeypox, avian influenza, and c…
View article: Gut microbiota and its metabolites regulate insulin resistance: traditional Chinese medicine insights for T2DM
Gut microbiota and its metabolites regulate insulin resistance: traditional Chinese medicine insights for T2DM Open
The gut microbiota is closely associated with the onset and development of type 2 diabetes mellitus (T2DM), characterized by insulin resistance (IR) and chronic low-grade inflammation. However, despite the widespread use of first-line anti…
View article: The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis
The association of gut microbiota, immunocyte dynamics, and protein–protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis Open
This study focused on the relationships among gut microbiota, plasma protein ratios, and tuberculosis. Given the unclear causal relationship between gut microbiota and tuberculosis and the scarcity of research on relevant plasma protein ra…
View article: Mesenchymal Stem Cells Reduce Inflammation in a Mouse Model of Lyme Arthritis
Mesenchymal Stem Cells Reduce Inflammation in a Mouse Model of Lyme Arthritis Open
Lyme disease (LD), a zoonotic infectious disease caused by Borrelia burgdorferi ( B. burgdorferi ), can affect various organs, including the skin, heart, nervous system, and joints. Lyme arthritis (LA) is the most common and severe late‐st…
View article: Global prevalence of <i>Borrelia burgdorferi</i> and <i>Anaplasma phagocytophilum</i> coinfection in wild and domesticated animals: A systematic review and meta-analysis
Global prevalence of <i>Borrelia burgdorferi</i> and <i>Anaplasma phagocytophilum</i> coinfection in wild and domesticated animals: A systematic review and meta-analysis Open
Spatial epidemiology showed that coinfection with Bb and Ap in animals worldwide was most prevalent in the southwestern region of North America, whereas species epidemiology showed that coinfection was most prevalent in domesticated horses…
View article: Virus-Induced Gene Silencing (VIGS) in Hydrangea macrophylla and Functional Analysis of HmF3′5′H
Virus-Induced Gene Silencing (VIGS) in Hydrangea macrophylla and Functional Analysis of HmF3′5′H Open
Hydrangea macrophylla, renowned for its large inflorescences and a diverse range of colors, highlights a significant limitation in current gene function research, which is the lack of effective molecular genetic tools. This study utilized …
View article: Diagnostic Accuracy of Mycobacterium tuberculosis Antigen-Based Skin Tests (TBSTs) for Tuberculosis Infection Compared with TST and IGRA: A Network Meta-Analysis
Diagnostic Accuracy of Mycobacterium tuberculosis Antigen-Based Skin Tests (TBSTs) for Tuberculosis Infection Compared with TST and IGRA: A Network Meta-Analysis Open
The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods an…
View article: Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages
Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages Open
Backfat thickness is an important economic trait that affects pork quality and flavor. The Lijiang pig (LJP), a local breed in Yunnan province, China, exhibits variations in growth and body composition. However, the molecular basis for the…
View article: Identification of Key Candidate Genes Involved in Aluminum Accumulation in the Sepals of Hydrangea macrophylla
Identification of Key Candidate Genes Involved in Aluminum Accumulation in the Sepals of Hydrangea macrophylla Open
Hydrangea macrophylla (H. macrophylla), a species in the genus Hydrangea in the family Hydrangeaceae, is widely valued for its ornamental qualities in both domestic and international markets. Notably, H. macrophylla is known for its abilit…
View article: Cellular and Molecular Network Characteristics of TARM1-Related Genes in Mycobacterium tuberculosis Infections
Cellular and Molecular Network Characteristics of TARM1-Related Genes in Mycobacterium tuberculosis Infections Open
Tuberculosis (TB) is a global infectious threat, and the emergence of multidrug-resistant TB has become a major challenge in eradicating the disease that requires the discovery of new treatment strategies. This study aimed to elucidate the…
View article: CD4+ Effective Memory T Cell Markers GBP2 and LAG3 Are Risk Factors for PTB and COVID-19 Infection: A Study Integrating Single-Cell Expression Quantitative Trait Locus and Mendelian Randomization Analyses
CD4+ Effective Memory T Cell Markers GBP2 and LAG3 Are Risk Factors for PTB and COVID-19 Infection: A Study Integrating Single-Cell Expression Quantitative Trait Locus and Mendelian Randomization Analyses Open
Observational studies indicate that variations in peripheral blood mononuclear cell (PBMC) subsets are associated with an increased risk of pulmonary tuberculosis (PTB) and coronavirus disease 2019 (COVID-19), but causal validation is lack…
View article: Global prevalence of <i>Borrelia burgdorferi</i> and <i>Anaplasma phagocytophilum</i> coinfection in <i>Ixodes</i> tick populations: protocol for a systematic review and meta-analysis
Global prevalence of <i>Borrelia burgdorferi</i> and <i>Anaplasma phagocytophilum</i> coinfection in <i>Ixodes</i> tick populations: protocol for a systematic review and meta-analysis Open
Introduction Ixodes ticks are pivotal in transmitting diseases like Lyme disease and human granulocytic anaplasmosis, caused by Borrelia burgdorferi and Anaplasma phagocytophilum , respectively. These pathogens not only affect humans throu…
View article: Serological and molecular epidemiological investigation of Mediterranean spotted fever in Yunnan Province, China
Serological and molecular epidemiological investigation of Mediterranean spotted fever in Yunnan Province, China Open
This research reveals a correlation between MSF prevalence, geography, and climate in Yunnan. The paucity of prior studies underscores MSF's potential diagnostic challenges in the region. Comprehensive understanding of the pathogen's distr…
View article: Global Prevalence Of Borrelia Burgdorferi And Anaplasma Phygocytophilum Coinfection In Wild and Domesticated Animals: A Systematic Review and Meta-Analysis
Global Prevalence Of Borrelia Burgdorferi And Anaplasma Phygocytophilum Coinfection In Wild and Domesticated Animals: A Systematic Review and Meta-Analysis Open
View article: The intricate role of CCL5/CCR5 axis in Alzheimer disease
The intricate role of CCL5/CCR5 axis in Alzheimer disease Open
The morbidity and mortality associated with Alzheimer disease (AD), one of the most common neurodegenerative diseases, are increasing each year. Although both amyloid β and tau proteins are known to be involved in AD pathology, their detai…
View article: Serological and Molecular Epidemiological Investigation of Mediterranean Spotted Fever in Yunnan Province, China
Serological and Molecular Epidemiological Investigation of Mediterranean Spotted Fever in Yunnan Province, China Open
View article: Comprehensive analyses of transcriptomes induced by Lyme spirochete infection to CNS model system
Comprehensive analyses of transcriptomes induced by Lyme spirochete infection to CNS model system Open
Our study suggested that TLR6, ANGPT1, LDLR, SREBF1, TNC, and ITGA may be candidate mammal biomarkers for LNB, and the TLR6/PI3K-Akt signaling pathway may play an important role in LNB pathogenesis.
View article: Comprehensive analyses of transcriptomes induced by Lyme spirochete infection to CNS model system
Comprehensive analyses of transcriptomes induced by Lyme spirochete infection to CNS model system Open
Background Lyme disease is a zoonotic disease caused by infection with Borrelia burgdorferi (Bb), the involvement of the nervous system in Lyme disease is usually referred to as Lyme neuroborreliosis (LNB). LNB has diverse clinical manifes…
View article: Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Borrelia burgdorferi Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis
Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Borrelia burgdorferi Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis Open
Background Lyme neuroborreliosis (LNB) is one of the most dangerous manifestations of Lyme disease, but the pathogenesis and inflammatory mechanisms are not fully understood. Methods Cultured explants from the frontal cortex of rhesus monk…
View article: Identification of differentially expressed genes and hub genes of human hosts with tuberculosis through an integrated bioinformatics strategy
Identification of differentially expressed genes and hub genes of human hosts with tuberculosis through an integrated bioinformatics strategy Open
Background: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis . Until now, molecular mechanisms underlying the occurrence, development and prognosis of tuberculosis have not been fully characterized. The aim…
View article: Lung organoids, useful tools for investigating epithelial repair after lung injury
Lung organoids, useful tools for investigating epithelial repair after lung injury Open
Organoids are derived from stem cells or organ-specific progenitors. They display structures and functions consistent with organs in vivo. Multiple types of organoids, including lung organoids, can be generated. Organoids are applied widel…
View article: <i>Borrelia Burgdorferi</i> Basic Membrane Protein a Initiates Arthritis in the Tree Shrew
<i>Borrelia Burgdorferi</i> Basic Membrane Protein a Initiates Arthritis in the Tree Shrew Open
View article: Proteomic Analysis of Rhesus Macaque Brain Explants Infected With Borrelia Burgdorferi Identifies Host&nbsp;GAP-43 As A Potential Factor Associated With Lyme Neuroborreliosis
Proteomic Analysis of Rhesus Macaque Brain Explants Infected With Borrelia Burgdorferi Identifies Host GAP-43 As A Potential Factor Associated With Lyme Neuroborreliosis Open
Background: Lyme neuroborreliosis (LNB) is one of the most dangerous manifestations of Lyme disease, but the pathogenesis and inflammatory mechanisms are not fully understood. Methods: Cultured explants from the frontal cortex of rhesus mo…