Shouhao Zhou
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View article: Shiny-MAGEC: A Bayesian R shiny application for meta-analysis of censored adverse events
Shiny-MAGEC: A Bayesian R shiny application for meta-analysis of censored adverse events Open
Accurate assessment of adverse event (AE) incidence is critical in clinical research for drug safety. While meta-analysis serves as an essential tool to comprehensively synthesize the evidence across multiple studies, incomplete AE reporti…
View article: RaCE: A rank-clustering estimation method for network meta-analysis
RaCE: A rank-clustering estimation method for network meta-analysis Open
Ranking multiple interventions is a crucial task in network meta-analysis (NMA) to guide clinical and policy decisions. However, conventional ranking methods often oversimplify treatment distinctions, potentially yielding misleading conclu…
View article: Effects of Hydrocodone Rescheduling on Pain Management Practices Among Older Breast Cancer Patients
Effects of Hydrocodone Rescheduling on Pain Management Practices Among Older Breast Cancer Patients Open
Hydrocodone, a commonly prescribed opioid, was rescheduled from Schedule III to Schedule II in October 2014, imposing stricter prescribing regulations. While prior studies have examined its effects in general populations, its impact on bre…
View article: Advancing postoperative mortality prediction in gastrectomy: a machine learning approach using NSQIP data
Advancing postoperative mortality prediction in gastrectomy: a machine learning approach using NSQIP data Open
Background Accurate prediction of mortality risk in gastrectomy is critical to optimize surgical management and improve patient outcomes. This study aims to develop machine learning (ML) models for predicting 30-day postoperative mortality…
View article: WOW: WAIC-Optimized Gating of Mixture Priors for External Data Borrowing
WOW: WAIC-Optimized Gating of Mixture Priors for External Data Borrowing Open
The integration of external data using Bayesian mixture priors has become a powerful approach in clinical trials, offering significant potential to improve trial efficiency. Despite their strengths in analytical tractability and practical …
View article: Factors associated with post-stroke readmission: a systematic review and meta analysis
Factors associated with post-stroke readmission: a systematic review and meta analysis Open
Readmissions following strokes are a significant concern due to their association with adverse outcomes. The Centers for Medicare and Medicaid Services regard hospital readmissions as a measure of suboptimal hospital care and have made red…
View article: Mano Technical Report
Mano Technical Report Open
Graphical user interfaces (GUIs) are the primary medium for human-computer interaction, yet automating GUI interactions remains challenging due to the complexity of visual elements, dynamic environments, and the need for multi-step reasoni…
View article: Impact of Soil Quality on Cannabinoid and Terpenoid Content of Cannabis sativa L.
Impact of Soil Quality on Cannabinoid and Terpenoid Content of Cannabis sativa L. Open
Cannabis sativa L., or ‘hemp,’ is an expanding commodity that relies heavily on its chemical constituents for its therapeutic effects and legal status. Growing conditions are critical for obtaining an anticipated chemical profile for any g…
View article: Nature-inspired metaheuristics for optimizing dose-finding and computationally challenging clinical trial designs
Nature-inspired metaheuristics for optimizing dose-finding and computationally challenging clinical trial designs Open
Metaheuristics are commonly used in computer science and engineering to solve optimization problems, but their potential applications in clinical trial design have remained largely unexplored. This article provides a brief overview of meta…
View article: Hydrocodone Rescheduling and Opioid Prescribing Disparities in Breast Cancer Patients
Hydrocodone Rescheduling and Opioid Prescribing Disparities in Breast Cancer Patients Open
Background: Pain is a prevalent issue among breast cancer patients and survivors, with a significant proportion receiving hydrocodone for pain management. However, the rescheduling of hydrocodone from Schedule III to Schedule II by the U.S…
View article: Association Between Physical Activity Dose and Mental Health Among Stroke Survivors
Association Between Physical Activity Dose and Mental Health Among Stroke Survivors Open
Background Although physical activity correlates with reduced depressive symptoms among survivors of stroke, how frequency, intensity, and duration of physical activity relate to mental health is unknown. This study aims to find the associ…
View article: Functional immune profiling of hyper- and hypo-inflammatory subphenotypes of critical illness: a secondary analysis
Functional immune profiling of hyper- and hypo-inflammatory subphenotypes of critical illness: a secondary analysis Open
Introduction Recent studies of adult sepsis patients demonstrate the existence of two subphenotypes that differ in risk of mortality: a hyper-inflammatory subphenotype with a high risk of mortality, and a hypo-inflammatory or “not hyper-in…
View article: The health-related quality of life among survivors with post-COVID conditions in the United States
The health-related quality of life among survivors with post-COVID conditions in the United States Open
Background Even after a mild initial SARS-CoV-2 infection, a considerable proportion of patients experience long-lasting symptoms. However, there is scarce data on how post-COVID conditions (PCCs) are associated with health-related quality…
View article: Posterior Predictive Design for Phase I Clinical Trials
Posterior Predictive Design for Phase I Clinical Trials Open
Interval-based designs represent cutting-edge adaptive methodologies for phase I clinical trials to identify the maximum tolerated dose (MTD). These designs exhibit robust performance comparable to more intricate, model-based designs, and …
View article: Extubation of patients with COVID-19 acute respiratory failure during extracorporeal membrane oxygenation support is associated with improved survival
Extubation of patients with COVID-19 acute respiratory failure during extracorporeal membrane oxygenation support is associated with improved survival Open
Aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, infection resulting in acute respiratory distress syndrome (ARDS) requiring veno-venous or veno-arterial extracorporeal membrane oxygenation (VV or VA-ECMO) su…
View article: Chance‐Corrected Interrater Agreement Statistics for Two‐Rater Dichotomous Responses: A Method Review With Comparative Assessment Under Possibly Correlated Decisions
Chance‐Corrected Interrater Agreement Statistics for Two‐Rater Dichotomous Responses: A Method Review With Comparative Assessment Under Possibly Correlated Decisions Open
Summary Measurement of the interrater agreement (IRA) is critical for assessing the reliability and validity of ratings in various disciplines. While numerous IRA statistics have been developed, there is a lack of guidance on selecting app…
View article: Cost-Effectiveness of Fruquintinib for Refractory Metastatic Colorectal Cancer in the USA
Cost-Effectiveness of Fruquintinib for Refractory Metastatic Colorectal Cancer in the USA Open
Despite the survival benefit, fruquintinib was not cost-effective compared with the placebo in patients with refractory metastatic colorectal cancer in the US setting, on the basis of the conventional willingness-to-pay threshold. Our find…
View article: Self-Management among Stroke Survivors in the United States, 2016 to 2021
Self-Management among Stroke Survivors in the United States, 2016 to 2021 Open
Background: Self-management among stroke survivors is effective in mitigating the risk of a recurrent stroke. This study aims to determine the prevalence of self-management and its associated factors among stroke survivors in the United St…
View article: The effect of balanced energy-protein supplementation provided to lactating women on maternal and infant outcomes: study protocol for a prospectively planned individual patient data (IPD) meta-analysis
The effect of balanced energy-protein supplementation provided to lactating women on maternal and infant outcomes: study protocol for a prospectively planned individual patient data (IPD) meta-analysis Open
* Background The high prevalence of infant stunting and maternal undernutrition in low- and middle-income countries poses a significant public health threat. The World Health Organization recommends balanced energy-protein (BEP) supplement…
View article: Outcomes of critically ill children with pre‐existing mental health conditions
Outcomes of critically ill children with pre‐existing mental health conditions Open
Importance Critically ill children with pre‐existing mental health conditions may have an increased risk of poor health outcomes. Objective We aimed to evaluate if pre‐existing mental health conditions in critically ill pediatric patients …
View article: Interrater agreement statistics under the two-rater dichotomous-response case with correlated decisions
Interrater agreement statistics under the two-rater dichotomous-response case with correlated decisions Open
Measurement of the interrater agreement (IRA) is critical in various disciplines. To correct for potential confounding chance agreement in IRA, Cohen's kappa and many other methods have been proposed. However, owing to the varied strategie…
View article: Predicting operative time for metabolic and bariatric surgery using machine learning models: a retrospective observational study
Predicting operative time for metabolic and bariatric surgery using machine learning models: a retrospective observational study Open
Background: Predicting operative time is essential for scheduling surgery and managing the operating room. This study aimed to develop machine learning (ML) models to predict the operative time for metabolic and bariatric surgery (MBS) and…
View article: Opioid Overdose Hospitalizations During COVID-19: The Experience of Pennsylvania
Opioid Overdose Hospitalizations During COVID-19: The Experience of Pennsylvania Open
Objective: The COVID-19 pandemic placed extreme burden on hospitals, while opioid overdose is another challenging public health issue. This study aimed to examine the trends and outcomes of opioid overdose hospitalizations in Pennsylvania …