Suzanne J. Reid
YOU?
Author Swipe
View article: Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease
Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease Open
Alzheimer's disease (AD) is a neurodegenerative condition and one of the most significant medical challenges today. Dominant mutations causing early-onset AD have been identified in the presenilin 1 and 2 (PSEN1 and PSEN2), and the amyloid…
View article: Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model
Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model Open
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by an expansion in the CAG repeat tract of the huntingtin (HTT) gene resulting in behavioural, cognitive, and motor defects. Current knowledge of disease pathogenesis…
View article: Somatic CAG Repeat Stability in a Transgenic Sheep Model of Huntington’s Disease
Somatic CAG Repeat Stability in a Transgenic Sheep Model of Huntington’s Disease Open
Somatic instability of the huntingtin (HTT) CAG repeat mutation modifies age-at-onset of Huntington’s disease (HD). Understanding the mechanism and pathogenic consequences of instability may reveal therapeutic targets. Using small-pool PCR…
View article: Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington’s Disease Sheep Support a Prodromal Disease State
Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington’s Disease Sheep Support a Prodromal Disease State Open
Background: Synaptic changes occur early in patients with Huntington’s disease (HD) and in mouse models of HD. An analysis of synaptic changes in HD transgenic sheep (OVT73) is fitting since they have been shown to have some phenotypes. Th…
View article: Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington’s Disease model
Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington’s Disease model Open
Background Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by an expansion in the CAG repeat tract of the huntingtin ( HTT ) gene resulting in a triad of behavioural, cognitive, and motor defects. Current knowledge…
View article: Evidence for glutamate excitotoxicity that occurs before the onset of cell loss and motor symptoms in an ovine Huntington's Disease model.
Evidence for glutamate excitotoxicity that occurs before the onset of cell loss and motor symptoms in an ovine Huntington's Disease model. Open
Background Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by an expansion in the CAG repeat tract of the huntingtin (HTT) gene resulting in a triad of behavioural, cognitive, and motor de…
View article: Isolated nuclei from frozen tissue are the superior source for single cell RNA-seq compared with whole cells
Isolated nuclei from frozen tissue are the superior source for single cell RNA-seq compared with whole cells Open
The isolation of intact single cells from frozen tissue is a challenge due to the mechanical and physical stress inflicted upon the cell during the freeze-thaw process. Ruptured cells release ambient RNA into the cell suspension, which can…
View article: HERDSA TATAL tales: Reflecting on academic growth as a Community for Practice
HERDSA TATAL tales: Reflecting on academic growth as a Community for Practice Open
View article: A Multi-Omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis
A Multi-Omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis Open
Background: The pathological mechanism of cellular dysfunction and death in Huntington’s disease (HD) is not well defined. Our transgenic HD sheep model (OVT73) was generated to investigate these mechanisms and for therapeutic testing. One…
View article: Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains
Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains Open
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene. Emerging evidence shows that additional epigenetic factors can modify disease phenotypes. Harnessing…
View article: Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease Open
Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive a…
View article: Modelling brain dopamine-serotonin vesicular transport disease in <i>Caenorhabditis elegans</i>
Modelling brain dopamine-serotonin vesicular transport disease in <i>Caenorhabditis elegans</i> Open
Brain dopamine-serotonin vesicular transport disease is a rare disease caused by autosomal recessive mutations in the SLC18A2 gene, which encodes the VMAT2 protein. VMAT2 is a membrane protein responsible for vesicular transport of monoami…
View article: Brain urea increase is an early Huntington’s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases
Brain urea increase is an early Huntington’s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases Open
Significance We present evidence for the presymptomatic dysregulation of urea metabolism in Huntington’s disease (HD). We identified increased levels of a urea transporter transcript and other osmotic regulators in the striatum of our prod…
View article: Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease
Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease Open
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant HTT, but evi…
View article: Potential molecular consequences of transgene integration: The R6/2 mouse example
Potential molecular consequences of transgene integration: The R6/2 mouse example Open
View article: Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain
Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain Open
Huntington's disease (HD) is a genetically-mediated neurodegenerative disorder wherein the aetiological defect is a mutation in the Huntington's gene (HTT), which alters the structure of the huntingtin protein (Htt) through lengthening of …
View article: Metabolic disruption identified in the Huntington’s disease transgenic sheep model
Metabolic disruption identified in the Huntington’s disease transgenic sheep model Open
Huntington’s disease (HD) is a dominantly inherited, progressive neurodegenerative disorder caused by a CAG repeat expansion within exon 1 of HTT , encoding huntingtin. There are no therapies that can delay the progression of this devastat…
View article: Glutamate and histidine improve both solvent yields and the acid tolerance response of <i>Clostridium beijerinckii</i> NCP 260
Glutamate and histidine improve both solvent yields and the acid tolerance response of <i>Clostridium beijerinckii</i> NCP 260 Open
This study aims to examine the effect of amino acid supplementation on solvent production by Clostridium beijerinckii during the acetone-butanol fermentation and to determine whether amino acids are involved in the acid tolerance response …
View article: Rapid RNA analysis of individual Caenorhabditis elegans
Rapid RNA analysis of individual Caenorhabditis elegans Open