Suzanne King
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View article: DNA Methylation Mediates the Association Between Prenatal Maternal Stress and the Broad Autism Phenotype in Human Adolescents: Project Ice Storm
DNA Methylation Mediates the Association Between Prenatal Maternal Stress and the Broad Autism Phenotype in Human Adolescents: Project Ice Storm Open
Prenatal maternal stress (PNMS) predicts risk for autism spectrum disorders (ASD), although the mechanisms are unknown. Because ASD and autistic-like traits have been associated with both prenatal stress and DNA methylation differences, it…
View article: Amygdala and Hippocampal Contributions to Broad Autism Phenotype: Project Ice Storm
Amygdala and Hippocampal Contributions to Broad Autism Phenotype: Project Ice Storm Open
Prenatal maternal stress (PNMS) increases the risk for autism, and individuals with autism inconsistently exhibit increased or decreased volumes and functional connectivity of the whole amygdala and the whole hippocampus. Given heterogeneo…
View article: DNA Methylation, Prenatal Maternal Stress and the Broad Autism Phenotype in Adolescence: Project Ice Storm
DNA Methylation, Prenatal Maternal Stress and the Broad Autism Phenotype in Adolescence: Project Ice Storm Open
Background/Objectives. Prenatal maternal stress (PNMS) predicts risk for autism spectrum disorders (ASD) although the mechanisms are unknown. The aim of this study was to determine the extent to which DNA methylation mediates the effects o…
View article: A Usability Analysis and Consequences of Testing Exploration of the Problem-Solving Measures–Computer-Adaptive Test
A Usability Analysis and Consequences of Testing Exploration of the Problem-Solving Measures–Computer-Adaptive Test Open
Testing is a part of education around the world; however, there are concerns that consequences of testing is underexplored within current educational scholarship. Moreover, usability studies are rare within education. One aim of the presen…
View article: Prenatal maternal subjective distress predicts higher autistic-like traits in offspring: The Iowa Flood Study
Prenatal maternal subjective distress predicts higher autistic-like traits in offspring: The Iowa Flood Study Open
Autism spectrum disorder prevalence more than quadrupled in the United States between 2000 and 2020. Ice storm-related prenatal maternal stress (PNMS) predicts autistic-like trait severity in children exposed early in gestation. The object…
View article: Pandemic-related prenatal maternal stress, model of maternity care and postpartum mental health: The Australian BITTOC study
Pandemic-related prenatal maternal stress, model of maternity care and postpartum mental health: The Australian BITTOC study Open
These results suggest that continuity of private midwifery care may be beneficial for supporting postpartum mental health during a pandemic, with implications for practice and policy for the current and future pandemics.
View article: Decreased amygdala-sensorimotor connectivity mediates the association between prenatal stress and broad autism phenotype in young adults: Project Ice Storm
Decreased amygdala-sensorimotor connectivity mediates the association between prenatal stress and broad autism phenotype in young adults: Project Ice Storm Open
Studies show that prenatal maternal stress (PNMS) is related to risk for child autism, and to atypical amygdala functional connectivity in the autistic child. Yet, it remains unclear whether amygdala functional connectivity mediates the as…
View article: Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm
Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm Open
Individuals with autism inconsistently exhibit increased or decreased volumes and functional connectivity of the whole amygdala and the whole hippocampus. Given heterogeneous structures of the amygdala and hippocampus and the heterogeneity…
View article: Atypical brain structure and function in young adults exposed to disaster‐related prenatal maternal stress: Project Ice Storm
Atypical brain structure and function in young adults exposed to disaster‐related prenatal maternal stress: Project Ice Storm Open
Studies have shown that prenatal maternal stress (PNMS) affects brain structure and function in childhood. However, less research has examined whether PNMS effects on brain structure and function extend to young adulthood. We recruited wom…
View article: The impact of prenatal maternal mental health during the COVID-19 pandemic on birth outcomes: two nested case-control studies within the CONCEPTION cohort
The impact of prenatal maternal mental health during the COVID-19 pandemic on birth outcomes: two nested case-control studies within the CONCEPTION cohort Open
Objective Assess the association between prenatal mental health during the COVID-19 pandemic and preterm birth (PTB; delivery < 37 weeks gestation) and low birth weight (LBW; < 2500 g). Methods Pregnant individuals, > 18 years, were recrui…
View article: The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta Open
Background : Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used to explore the connections between in utero exposures, placental pathology, and fetal development. Howe…
View article: Preconception and prenatal maternal stress are associated with broad autism phenotype in young adults: Project Ice Storm
Preconception and prenatal maternal stress are associated with broad autism phenotype in young adults: Project Ice Storm Open
Studies show associations between prenatal maternal stress (PNMS) and child autism, with little attention paid to PNMS and autism in young adulthood. The broad autism phenotype (BAP), encompassing sub-clinical levels of autism, includes al…
View article: Urinary 1H NMR Metabolomic Analysis of Prenatal Maternal Stress Due to a Natural Disaster Reveals Metabolic Risk Factors for Non-Communicable Diseases: The QF2011 Queensland Flood Study
Urinary 1H NMR Metabolomic Analysis of Prenatal Maternal Stress Due to a Natural Disaster Reveals Metabolic Risk Factors for Non-Communicable Diseases: The QF2011 Queensland Flood Study Open
Prenatal stress alters fetal programming, potentially predisposing the ensuing offspring to long-term adverse health outcomes. To gain insight into environmental influences on fetal development, this QF2011 study evaluated the urinary meta…
View article: Maternal mental health mediates the effect of prenatal stress on infant temperament: The Harvey Mom Study
Maternal mental health mediates the effect of prenatal stress on infant temperament: The Harvey Mom Study Open
Prenatal maternal stress and mental health problems are known to increase risk for developmental psychopathology in offspring, yet pathways leading to risk or resiliency are poorly understood. In a quasi-experimental design, we prospective…
View article: Prenatal maternal stress was not associated with birthweight or gestational age at birth during <scp>COVID</scp>‐19 restrictions in Australia: The <scp>BITTOC</scp> longitudinal cohort study
Prenatal maternal stress was not associated with birthweight or gestational age at birth during <span>COVID</span>‐19 restrictions in Australia: The <span>BITTOC</span> longitudinal cohort study Open
Background Various forms of prenatal maternal stress (PNMS) have been reported to increase risk for preterm birth and low birthweight. However, the associations between specific components of stress – namely objective hardship and subjecti…
View article: Cumulative and compounding effects of pre-pandemic vulnerabilities and pandemic-related hardship on psychological distress among pregnant individuals
Cumulative and compounding effects of pre-pandemic vulnerabilities and pandemic-related hardship on psychological distress among pregnant individuals Open
Objective: Our primary objective was to determine whether pre-existing vulnerabilities and pandemic-related hardship resulted in cumulative (i.e., additive) versus compounding (i.e., multiplicative) effects on psychological distress in pre…
View article: Neural correlates of disaster-related prenatal maternal stress in young adults from Project Ice Storm: Focus on amygdala, hippocampus, and prefrontal cortex
Neural correlates of disaster-related prenatal maternal stress in young adults from Project Ice Storm: Focus on amygdala, hippocampus, and prefrontal cortex Open
Background Studies have shown that prenatal maternal stress alters volumes of the amygdala and hippocampus, and alters functional connectivity between the amygdala and prefrontal cortex. However, it remains unclear whether prenatal materna…
View article: The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort Open
The effect of the COVID-19 pandemic on maternal mental health has been described in Canada and China but no study has compared the two countries using the same standardized and validated instruments. In this study, we aimed to evaluate and…
View article: Association between Anxiety and Disease Pathophysiology in Participants of Longitudinal Observational Studies in Aging during the COVID-19 Lockdown
Association between Anxiety and Disease Pathophysiology in Participants of Longitudinal Observational Studies in Aging during the COVID-19 Lockdown Open
The burden imposed by the COVID-19 pandemic deferentially interferes with the outcomes of clinical trials of aging and dementia. We examined the impact of the lockdown on cognitive impairment due to Alzheimer’s Disease (AD), anxiety, and C…
View article: Perinatal Depression in Australian Women during the COVID-19 Pandemic: The Birth in the Time of COVID-19 (BITTOC) Study
Perinatal Depression in Australian Women during the COVID-19 Pandemic: The Birth in the Time of COVID-19 (BITTOC) Study Open
The COVID-19 pandemic has impacted perinatal mental health globally. We determined the maternal factors and pandemic-related experiences associated with clinically significant perinatal (pregnant and post-partum) depressive symptoms in Aus…
View article: The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation
The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation Open
Introduction: We aimed to measure the impact of the COVID-19 pandemic on maternal mental health, stratifying on pregnancy status, trimester of gestation, and pandemic period/wave. Methods: Pregnant persons and persons who delivered in Cana…
View article: The COVID-19 pandemic impacted maternal mental health differently depending on pregnancy status and trimester of gestation
The COVID-19 pandemic impacted maternal mental health differently depending on pregnancy status and trimester of gestation Open
Introduction: We aimed to measure the impact of the COVID-19 pandemic on maternal mental health, stratifying on pregnancy status, trimester of gestation, and pandemic period/wave.Methods: Pregnant persons and persons who delivered in Canad…
View article: The effects of childhood adversity on treatment delays and its components in first-episode psychosis
The effects of childhood adversity on treatment delays and its components in first-episode psychosis Open
Apart from increasing risk for psychotic disorders, childhood adversity has been associated with worse outcomes. One way in which childhood adversity may worsen outcomes is by lengthening treatment delays, which are associated with negativ…
View article: COVID‐19 pandemic: Quantifying the effects of the first lockdown on behavioral and cognitive measures using TASIC
COVID‐19 pandemic: Quantifying the effects of the first lockdown on behavioral and cognitive measures using TASIC Open
Background Following the rapid spread of the COVID‐19 virus throughout Quebec, the TRIAD cohort, a longitudinal observational study, evaluated the effects of COVID‐19 on it’s aging and vulnerable population and their caregivers. This study…