Suzanne S. Fei
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View article: Chronic Ethanol Drinking Alters Medial Prefrontal Cortex and Nucleus Accumbens Astrocyte Translatome and Extracellular Matrix Glycosaminoglycans
Chronic Ethanol Drinking Alters Medial Prefrontal Cortex and Nucleus Accumbens Astrocyte Translatome and Extracellular Matrix Glycosaminoglycans Open
Alcohol Use Disorder is a leading preventable cause of morbidity and mortality, yet knowledge of mechanisms driving ethanol-related neuroplasticity remains incomplete. While research has traditionally focused on neuronal signaling, emergin…
View article: Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion
Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion Open
Summary The Yamanaka factors (OCT4, SOX2, KLF4, and MYC; OSKM) can rejuvenate aging phenotypes in somatic cell types by resetting the epigenetic landscape. Curiously, most solid tumor cells remain largely resistant to reprogramming despite…
View article: Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity
Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity Open
Our data revealed significant immunometabolic perturbations in the bone marrow and myeloid cells in the newly weaned offspring born to mothers with obesity. Adaptation to an adverse maternal intrauterine environment affects bone marrow met…
View article: Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity
Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal obesity Open
Maternal obesity puts the offspring at high risk of developing obesity and cardio-metabolic diseases in adulthood. Here, using a mouse model of maternal high-fat diet (HFD)-induced obesity, we show that whole body fat content of the offspr…
View article: Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques
Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques Open
Male rhesus monkeys ( n = 24) had a biopsy of prefrontal cortical area 46 prior to chronic ethanol self-administration ( n = 17) or caloric control ( n = 7). Fourteen months of daily self-administration (water vs. 4% alcohol, 22 h access/d…
View article: Mayaro virus pathogenesis and immunity in rhesus macaques
Mayaro virus pathogenesis and immunity in rhesus macaques Open
Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pathogenesis is current…
View article: Optic Nerve Head Gene Transcription Sequelae to a Single Elevated IOP Exposure Provides Insights Into Known Responses to Chronically Elevated IOP
Optic Nerve Head Gene Transcription Sequelae to a Single Elevated IOP Exposure Provides Insights Into Known Responses to Chronically Elevated IOP Open
The PT-CEI model places in sequence ONH gene expression responses previously reported in models with chronically elevated IOP and may provide insights into their role in optic nerve damage.
View article: Transcriptional profiling of mucus production and modification in rhesus macaque endocervical cells under hormonal regulation
Transcriptional profiling of mucus production and modification in rhesus macaque endocervical cells under hormonal regulation Open
Objective Endocervical mucus production is a key regulator of fertility throughout the menstrual cycle. With cycle-dependent variability in mucus quality and quantity, cervical mucus can either facilitate or block sperm ascension into the …
View article: A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder
A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder Open
Alcohol use disorder (AUD) is a complex mental health condition. Currently available clinical treatments exhibit limited efficacy and new druggable targets are required. One promising approach to discover new molecular treatment targets in…
View article: The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques
The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques Open
Polycystic ovary syndrome (PCOS) is associated with irregular menstrual cycles, hyperandrogenemia, and obesity. It is currently accepted that women with PCOS are also at risk for endometriosis, but the effect of androgen and obesity on end…
View article: Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development
Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development Open
Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure or spontaneous miscarriage in both natural and assisted reproduction. Despite our knowledge of mitotic mis-segregation in somatic cells, th…
View article: Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques
Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques Open
View article: Molecular and Cellular Characterization of Pyoderma Gangrenosum: Implications for the Use of Gene Expression
Molecular and Cellular Characterization of Pyoderma Gangrenosum: Implications for the Use of Gene Expression Open
View article: Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model
Effects of early daily alcohol exposure on placental function and fetal growth in a rhesus macaque model Open
View article: Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome
Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome Open
The nucleus accumbens core (NAcc) has been repeatedly demonstrated to be a key component of the circuitry associated with excessive ethanol consumption. Previous studies have illustrated that in a nonhuman primate (NHP) model of chronic et…
View article: Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis
Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis Open
View article: Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Open
Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis usi…
View article: Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics
Revising the Diagnosis of Idiopathic Uveitis by Peripheral Blood Transcriptomics Open
View article: Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates
Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates Open
The present global transcriptomic analyses demonstrate that the greatest magnitude of changes occurred in contrasts of C and T versus T+WSD, adding to the evidence that these two insults have a synergistic effect on female physiology. Thes…
View article: IDENTIFICATION OF TRANSCRIPTOMIC CHANGES TO EUTOPIC ENDOMETRIUM BY PRESENCE OF ENDOMETRIOTIC CYSTS – HARNESSING THE POWER OF EXISTING NONHUMAN PRIMATE DATASETS
IDENTIFICATION OF TRANSCRIPTOMIC CHANGES TO EUTOPIC ENDOMETRIUM BY PRESENCE OF ENDOMETRIOTIC CYSTS – HARNESSING THE POWER OF EXISTING NONHUMAN PRIMATE DATASETS Open
View article: RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method
RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method Open
Peripheral blood is a highly accessible biofluid providing a rich source of information about human physiology and health status. However, for studies of the blood transcriptome with RNA sequencing (RNA-Seq) techniques, high levels of hemo…
View article: Molecular Contribution to Embryonic Aneuploidy and Genotypic Complexity During Initial Cleavage Divisions of Mammalian Development
Molecular Contribution to Embryonic Aneuploidy and Genotypic Complexity During Initial Cleavage Divisions of Mammalian Development Open
Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure, or spontaneous miscarriage in both natural and assisted reproduction. Despite our knowledge of mitotic mis-segregation in somatic cells, t…
View article: Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection
Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection Open
Ischemia-reperfusion injury (IRI) is an important risk factor for accelerated cardiac allograft rejection and graft dysfunction . Utilizing a rat heart isogeneic transplant model, we identified inflammatory pathways involved in IRI in orde…
View article: RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method
RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method Open
Molecular analysis of lymphoid tissue from rhesus macaque rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis Open
View article: Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates
Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates Open
View article: RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery Open
Background Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich clinical data, and association with patient outcomes. However, FFPE-d…
View article: Transcriptome analysis during photostimulated recrudescence reveals distinct patterns of gene regulation in Siberian hamster ovaries†
Transcriptome analysis during photostimulated recrudescence reveals distinct patterns of gene regulation in Siberian hamster ovaries† Open
In Siberian hamsters, exposure to short days (SDs, 8 h light:16 h dark) reduces reproductive function centrally by decreasing gonadotropin secretion, whereas subsequent transfer of photoinhibited hamsters to stimulatory long days (LDs, 16 …
View article: Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats
Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats Open
The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of sympathetic nerves projecting to the heart has been observed in several cardiovascular diseases, and sympathetic dysfunction contributes…
View article: Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion
Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion Open
Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo loss. We previously showed that human preimplantation embryos encapsulate missegregated chromosomes into micronuclei while undergoing cellular frag…