Suzette J. Bielinski
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View article: PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse
PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse Open
Background Computational phenotyping from electronic health records (EHRs) is essential for clinical research, decision support, and quality/population health assessment, but the proliferation of algorithms for the same conditions makes it…
View article: Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort
Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort Open
BACKGROUND: Heart failure (HF) is a heterogeneous syndrome with high mortality. The need for a new taxonomy of HF is recognized; up to now, such phenomapping efforts have primarily used clinical data. Proteomics offers potential for more p…
View article: Patients’ Concerns About Receiving Preemptive Pharmacogenomic Testing: Results from a Large, Longitudinal Survey of RIGHT Study Participants
Patients’ Concerns About Receiving Preemptive Pharmacogenomic Testing: Results from a Large, Longitudinal Survey of RIGHT Study Participants Open
Background: As more healthcare institutions consider providing preemptive pharmacogenomic (PGx) testing to greater numbers of their patients, it will be important to consider the potential concerns patients may have about the generation of…
View article: PhenoFit: A Framework for Determining Computable Phenotyping Algorithm Fitness for Purpose and Reuse
PhenoFit: A Framework for Determining Computable Phenotyping Algorithm Fitness for Purpose and Reuse Open
Background: Computational phenotyping from electronic health records (EHRs) is essential forclinical research, decision support, and quality/population health assessment, but theproliferation of algorithms for the same conditions makes it …
View article: Advancing efficacy prediction for electronic health records based emulated trials in repurposing heart failure therapies
Advancing efficacy prediction for electronic health records based emulated trials in repurposing heart failure therapies Open
View article: Cross-sectional evaluation of the metabolic vulnerability index in heart failure populations
Cross-sectional evaluation of the metabolic vulnerability index in heart failure populations Open
View article: Sangre Por Salud (SPS) Biobank: cohort profile
Sangre Por Salud (SPS) Biobank: cohort profile Open
Purpose The Sangre Por Salud (SPS) Biobank was established to facilitate biomedical research opportunities for the Latino community by creating an easily accessible prospective cohort for scientists interested in studying health conditions…
View article: Corrigendum: An Online Tool for Correcting Performance Measures of Electronic Phenotyping Algorithms for Verification Bias
Corrigendum: An Online Tool for Correcting Performance Measures of Electronic Phenotyping Algorithms for Verification Bias Open
View article: Health care concerns in women at midlife: differences by race, ethnicity, and neighborhood socioeconomic status
Health care concerns in women at midlife: differences by race, ethnicity, and neighborhood socioeconomic status Open
Objectives The aims of the study were to identify conditions diagnosed in at least 10% of midlife women living in the US upper midwest and to assess prevalence by age, race, ethnicity, and sociodemographic status. Methods The Rochester Epi…
View article: The clinical impact of estimating low-density lipoprotein cholesterol (LDL-C) using different equations in the general population
The clinical impact of estimating low-density lipoprotein cholesterol (LDL-C) using different equations in the general population Open
View article: An Online Tool for Correcting Performance Measures of Electronic Phenotyping Algorithms for Verification Bias
An Online Tool for Correcting Performance Measures of Electronic Phenotyping Algorithms for Verification Bias Open
Objectives Computable or electronic phenotypes of patient conditions are becoming more commonplace in quality improvement and clinical research. During phenotyping algorithm validation, standard classification performance measures (i.e., s…
View article: Discordance Between Very Low‐Density Lipoprotein Cholesterol and Low‐Density Lipoprotein Cholesterol Increases Cardiovascular Disease Risk in a Geographically Defined Cohort
Discordance Between Very Low‐Density Lipoprotein Cholesterol and Low‐Density Lipoprotein Cholesterol Increases Cardiovascular Disease Risk in a Geographically Defined Cohort Open
Background Clinical risk scores are used to identify those at high risk of atherosclerotic cardiovascular disease (ASCVD). Despite preventative efforts, residual risk remains for many individuals. Very low‐density lipoprotein cholesterol (…
View article: Lipoprotein Insulin Resistance Score and Mortality Risk Stratification in Heart Failure
Lipoprotein Insulin Resistance Score and Mortality Risk Stratification in Heart Failure Open
LP-IR score was inversely associated with mortality among patients with heart failure and may be driven by smaller HDL particle size.
View article: Frailty and Metabolic Vulnerability in Heart Failure: A Community Cohort Study
Frailty and Metabolic Vulnerability in Heart Failure: A Community Cohort Study Open
Background Frailty is common in heart failure (HF) and is associated with death but not routinely captured clinically. Frailty is linked with inflammation and malnutrition, which can be assessed by a novel plasma multimarker score: the met…
View article: Associations of Circulating Vascular Cell Adhesion Molecule‐1 and Intercellular Adhesion Molecule‐1 With Long‐Term Cardiac Function
Associations of Circulating Vascular Cell Adhesion Molecule‐1 and Intercellular Adhesion Molecule‐1 With Long‐Term Cardiac Function Open
Background Although VCAM‐1 (vascular cell adhesion molecule‐1) and ICAM‐1 (intercellular adhesion molecule‐1) have been associated with incident heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), the assoc…
View article: Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease: The atherosclerosis risk in communities (ARIC) study
Role of BMI in the association of the TCF7L2 rs7903146 variant with coronary heart disease: The atherosclerosis risk in communities (ARIC) study Open
We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (AR…
View article: The Importance of Estimating Excess Deaths Regionally During the COVID-19 Pandemic
The Importance of Estimating Excess Deaths Regionally During the COVID-19 Pandemic Open
View article: The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis
The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis Open
Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natu…
View article: Circulating ketone bodies and mortality in heart failure: a community cohort study
Circulating ketone bodies and mortality in heart failure: a community cohort study Open
Background The relationship between ketone bodies (KB) and mortality in patients with heart failure (HF) syndrome has not been well established. Objectives The aim of this study is to assess the distribution of KB in HF, identify clinical …
View article: Development and Validation of a Protein Risk Score for Mortality in Heart Failure
Development and Validation of a Protein Risk Score for Mortality in Heart Failure Open
Division of Intramural Research at the National Heart, Lung, and Blood Institute of the National Institutes of Health.
View article: An online tool for correcting verification bias when validating electronic phenotyping algorithms
An online tool for correcting verification bias when validating electronic phenotyping algorithms Open
Computable or electronic phenotypes of patient conditions are becoming more commonplace in quality improvement and clinical research. During phenotyping algorithm validation, standard classification performance measures (i.e., sensitivity,…
View article: Biomarkers of cellular senescence and risk of death in humans
Biomarkers of cellular senescence and risk of death in humans Open
A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In addition to mediators of age‐related pathology, components of the senescence associated secretory phenotype (SASP) have been studied as biomarkers …
View article: Risk of Adult Hypertension in Offspring From Pregnancies Complicated by Hypertension: Population-Based Estimates
Risk of Adult Hypertension in Offspring From Pregnancies Complicated by Hypertension: Population-Based Estimates Open
BACKGROUND: Hypertensive disorders of pregnancy (HDP) have been associated with an increased risk of chronic hypertension for both mothers and offspring. We sought to quantify the incidence of chronic hypertension in offspring from HDP-aff…
View article: The Metabolic Vulnerability Index
The Metabolic Vulnerability Index Open
View article: Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias
Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias Open
In a large EHR derived cohort, those in the highest quintile of variability for total cholesterol and triglyceride levels had an increased risk of incident AD/ADRD. Further studies to identify the mechanisms behind this association are nee…
View article: Advancing Efficacy Prediction for EHR-based Emulated Trials in Repurposing Heart Failure Therapies
Advancing Efficacy Prediction for EHR-based Emulated Trials in Repurposing Heart Failure Therapies Open
Introduction The High mortality rates associated with heart failure (HF) have propelled the strategy of drug repurposing, which seeks new therapeutic uses for existing, approved drugs to enhance the management of HF symptoms effectively. A…
View article: Automated Identification of Aspirin-Exacerbated Respiratory Disease Using Natural Language Processing and Machine Learning: Algorithm Development and Evaluation Study
Automated Identification of Aspirin-Exacerbated Respiratory Disease Using Natural Language Processing and Machine Learning: Algorithm Development and Evaluation Study Open
Background Aspirin-exacerbated respiratory disease (AERD) is an acquired inflammatory condition characterized by the presence of asthma, chronic rhinosinusitis with nasal polyposis, and respiratory hypersensitivity reactions on ingestion o…
View article: Health Care Utilization and Death in Patients With Heart Failure During the COVID-19 Pandemic
Health Care Utilization and Death in Patients With Heart Failure During the COVID-19 Pandemic Open
In this large population-based study in southeastern Minnesota, we observed an approximately 10% decrease in hospitalizations among patients with HF in 2020 and 2021 and a 15% decrease in ED visits in 2020 compared with those in 2019. Desp…
View article: Cohort study examining associations between ceramide levels and risk of multimorbidity among persons participating in the Mayo Clinic Biobank
Cohort study examining associations between ceramide levels and risk of multimorbidity among persons participating in the Mayo Clinic Biobank Open
Objective Ceramides have been associated with several ageing-related conditions but have not been studied as a general biomarker of multimorbidity (MM). Therefore, we determined whether ceramide levels are associated with the rapid develop…
View article: Assessing document section heterogeneity across multiple electronic health record systems for computational phenotyping: A case study of heart-failure phenotyping algorithm
Assessing document section heterogeneity across multiple electronic health record systems for computational phenotyping: A case study of heart-failure phenotyping algorithm Open
Background The incorporation of information from clinical narratives is critical for computational phenotyping. The accurate interpretation of clinical terms highly depends on their associated context, especially the corresponding clinical…