Suzhen Lin
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View article: Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus
Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus Open
The pathogenesis of koala retrovirus (KoRV) has been explored in various contexts, yet its role in tumorigenesis remains incompletely understood. Unlike acute transforming retroviruses, KoRV lacks a viral oncogene but may contribute to onc…
View article: Transcriptomics and Proteomics Identify Serotonin Transporter as a Promising Therapeutic Target for Essential Tremor
Transcriptomics and Proteomics Identify Serotonin Transporter as a Promising Therapeutic Target for Essential Tremor Open
Essential tremor (ET) stands as one of the most prevalent movement disorders originating from cerebellar dysfunction. However, effective treatment remains limited, largely due to a poor understanding of its molecular pathology. The harmali…
View article: Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model
Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model Open
Background Epidemiological studies have revealed increased Parkinson’s disease (PD) risk among individuals exposed to pesticides like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP is frequently used to induce PD-like symptoms i…
View article: Remote Programming for Deep Brain Stimulation among Patients with Isolated Dystonia: Patient Attitudes and Treatment Effect
Remote Programming for Deep Brain Stimulation among Patients with Isolated Dystonia: Patient Attitudes and Treatment Effect Open
Background Remote programming (RP) offers a convenient alternative for patients with isolated dystonia who have undergone deep brain stimulation (DBS). However, limited research has explored patients' attitudes toward RP and its clinical o…
View article: Hybrid Electric Propulsion Design and Analysis Based on Regional Aircraft Mission
Hybrid Electric Propulsion Design and Analysis Based on Regional Aircraft Mission Open
Hybrid propulsion systems have become a focal point of low-carbon aviation research due to their advantages in energy savings, emissions reduction, and noise abatement. This study develops an integrated design methodology for hybrid propul…
View article: A novel compound alleviates oxidative stress via <scp>PKA</scp>/<scp>CREB1</scp>‐mediated <scp>DJ</scp>‐1 upregulation
A novel compound alleviates oxidative stress via <span>PKA</span>/<span>CREB1</span>‐mediated <span>DJ</span>‐1 upregulation Open
Oxidative stress is one of the major culprits causing dopaminergic neuron loss in Parkinson's disease (PD). DJ‐1 is a protein with multiple actions against oxidative stress, apoptosis, neuroinflammation, etc. DJ‐1 expression is decreased i…
View article: Anterior capsulotomy combined with subthalamic nucleus deep brain stimulation for tardive dystonia
Anterior capsulotomy combined with subthalamic nucleus deep brain stimulation for tardive dystonia Open
Bilateral anterior capsulotomy combined with bilateral STN-DBS may be an effective and relatively safe treatment option for severe TD comorbid with major psychiatric disorders.
View article: Superior cerebellar peduncle deep brain stimulation for cerebral palsy
Superior cerebellar peduncle deep brain stimulation for cerebral palsy Open
OBJECTIVE Patients with coexisting spastic cerebral palsy (CP) and dystonia have limited treatment options. In this study, the authors aimed to evaluate the efficacy of deep brain stimulation (DBS) targeting the superior cerebellar peduncl…
View article: Multi-omics Identify Serotonin Transporter as a Promising Therapeutic Target for Essential Tremor
Multi-omics Identify Serotonin Transporter as a Promising Therapeutic Target for Essential Tremor Open
Essential tremor (ET) stands as one of the most prevalent cerebellar movement disorders. However, effective treatment remains elusive, largely due to a limited understanding of its molecular pathology. Harmaline-induced tremor in mouse is …
View article: Regulation of Hsa‐miR‐4639‐5p expression and its potential role in the pathogenesis of Parkinson's disease
Regulation of Hsa‐miR‐4639‐5p expression and its potential role in the pathogenesis of Parkinson's disease Open
Decreased DJ‐1 protein impairs antioxidative activity of neurons and plays an important role in the occurrence of Parkinson's disease (PD). We have previously identified hsa‐miR‐4639‐5p as the post‐transcriptional regulator of DJ‐1. Increa…
View article: Rescue procedure for isolated dystonia after the secondary failure of globus pallidus internus deep brain stimulation
Rescue procedure for isolated dystonia after the secondary failure of globus pallidus internus deep brain stimulation Open
Introduction Globus pallidus internus (GPi) deep brain stimulation (DBS) is widely used in patients with dystonia. However, 10–20% of patients receive insufficient benefits. The objectives of this study are to evaluate the effectiveness of…
View article: Identification of the Transcription Factors of CD200R1 and Its Potential Roles in Parkinson’s Disease
Identification of the Transcription Factors of CD200R1 and Its Potential Roles in Parkinson’s Disease Open
BackgroundNeuroinflammation is known to be involved in the pathogenesis of Parkinson's disease (PD). Abnormal activation of microglia plays a key role in this pathological process. CD200R1 is a membrane glycoprotein primarily expressed in …
View article: Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease Open
Background In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guanine nucleotide exch…
View article: High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy
High Frequency Deep Brain Stimulation of Superior Cerebellar Peduncles in a Patient with Cerebral Palsy Open
SCP DBS may be a potential treatment for cerebral palsy patients with dystonia and spasticity who do not respond well to GPi DBS.
View article: Additional file 6 of Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
Additional file 6 of Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease Open
Additional file 6: Table 1. Identify RIN3 interacting protein via Mass Spectrum. Recombinant flag tagged RIN3 protein were purified from HEK293T cells. RIN3-interactomes were identified by Mass Spectrometry. Two replicates were performed. …