Suzie Chen
YOU?
Author Swipe
Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner Open
Introduction Strong evidence suggests links between Parkinson’s Disease (PD) and melanoma, as studies have found that people with PD are at an increased risk of developing melanoma and those with melanoma are at increased risk of developin…
Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner Open
Strong evidence suggests links between Parkinson’s Disease (PD) and melanoma, as studies have found that people with PD are at an increased risk of developing melanoma and those with melanoma are at increased risk of developing PD. Althoug…
An In Vivo Study of <span>LNS8801</span>, a <span>GPER</span> Agonist, in a Spontaneous Melanoma‐Prone Mouse Model, <span>TGS</span> Open
Melanoma is the most aggressive and deadly form of skin cancer that arises from the transformation of melanocytes, the pigment producing cells of the skin. In the year 2024 there will be approximately 10,000 new cases of melanoma diagnosed…
In Vitro and In Vivo Studies of Melanoma Cell Migration by Antagonistic Mimetics of Adhesion Molecule L1CAM Open
Melanoma, the deadliest type of skin cancer, has a high propensity to metastasize to other organs, including the brain, lymph nodes, lungs, and bones. While progress has been made in managing melanoma with targeted and immune therapies, ma…
Current State of Melanoma Therapy and Next Steps: Battling Therapeutic Resistance Open
Melanoma is the most aggressive and deadly form of skin cancer due to its high propensity to metastasize to distant organs. Significant progress has been made in the last few decades in melanoma therapeutics, most notably in targeted thera…
Study on the Complex Melanoma Open
Melanoma only accounts for about 1% of cases in skin cancer, unlike basal cell and/or squamous cell carcinomas; however, it owes its notoriety to being the deadliest type of skin cancer [...]
Assessing Longitudinal Treatment Efficacies and Alterations in Molecular Markers Associated with Glutamatergic Signaling and Immune Checkpoint Inhibitors in a Spontaneous Melanoma Mouse Model Open
Previous work done by our laboratory described the use of an immunocompetent spontaneous melanoma-prone mouse model, TGS (TG-3/SKH-1), to evaluate treatment outcomes using inhibitors of glutamatergic signaling and immune checkpoint for 18 …
Overview of current melanoma therapies Open
Melanoma is the most aggressive type of skin cancer and is responsible for the majority of deaths from skin cancer. Therapeutic advances in the last few decades, notably the development of novel targeted therapies and immunotherapies have …
Editorial: The role of immunotherapy in melanomas Open
EDITORIAL article Front. Oncol., 28 September 2023Sec. Skin Cancer Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1293040
A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850 Open
Combination therapy with riluzole and sorafenib was safe and tolerable in patients with advanced solid tumors. The partial response in a patient with a RAF1 fusion suggests that further exploration in a genomically selected cohort may be w…
Supplementary Table S1 from Riluzole Enhances Ionizing Radiation–Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 <i>In Vitro</i> and <i>In Vivo</i> Open
Supplementary Table S1.
Supplementary Data from Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance Open
This file contains all supplementary figures with their legends, supplementary tables and supplementary methods
Data from Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance Open
Caspases are well known for their role in apoptosis. Recently, nonapoptotic roles of caspases have been identified, however, these noncanonical roles are not well documented and the mechanisms involved are not fully understood. Here, we st…
Supplementary Data from Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance Open
This file contains all supplementary figures with their legends, supplementary tables and supplementary methods
Data from Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance Open
Caspases are well known for their role in apoptosis. Recently, nonapoptotic roles of caspases have been identified, however, these noncanonical roles are not well documented and the mechanisms involved are not fully understood. Here, we st…
Supplementary Table S1 from Riluzole Enhances Ionizing Radiation–Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 <i>In Vitro</i> and <i>In Vivo</i> Open
Supplementary Table S1.
Data from Riluzole Enhances Ionizing Radiation–Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 <i>In Vitro</i> and <i>In Vivo</i> Open
Purpose: Brain metastases are a common preterminal event in patients with metastatic melanoma and require radiation therapy. Our group has previously shown that human GRM1 (hGRM1) expressing melanoma cells release excess extracellular glut…
Data from Riluzole Enhances Ionizing Radiation–Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 <i>In Vitro</i> and <i>In Vivo</i> Open
Purpose: Brain metastases are a common preterminal event in patients with metastatic melanoma and require radiation therapy. Our group has previously shown that human GRM1 (hGRM1) expressing melanoma cells release excess extracellular glut…
Data from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
Glutamate-triggered signal transduction is thought to contribute widely to cancer pathogenesis. In melanoma, overexpression of the metabotropic glutamate receptor (GRM)-1 occurs frequently and its ectopic expression in melanocytes is suffi…
Data from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca<sup>2+</sup>-Dependent Mechanism Open
Melanoma has a poor prognosis due to its strong metastatic ability. Although Ca2+ plays a major role in cell migration, little is known about the role of Ca2+ in melanoma cell migration. We recently found that the exchange protein directly…
Supplementary Figure 3 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
PDF file - 237KB, Supplemental Figure 3: Stable GRM1 knock-down cells lines were obtained by shRNA. 50% GRM1 protein level decrease in UACC9093-G4 cells dramatically decreased VEGF secretion, but 50% GRM1 protein level decrease in UACC903-…
Data from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca<sup>2+</sup>-Dependent Mechanism Open
Melanoma has a poor prognosis due to its strong metastatic ability. Although Ca2+ plays a major role in cell migration, little is known about the role of Ca2+ in melanoma cell migration. We recently found that the exchange protein directly…
Supplementary Figure 1 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
PDF file - 737KB, Supplemental Figure 1: Apoptosis antibody array result of Uacc903-V1 and -G2.
Data from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
Glutamate-triggered signal transduction is thought to contribute widely to cancer pathogenesis. In melanoma, overexpression of the metabotropic glutamate receptor (GRM)-1 occurs frequently and its ectopic expression in melanocytes is suffi…
Supplementary Materials, Figures 1-2 from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca<sup>2+</sup>-Dependent Mechanism Open
Supplementary Materials, Figures 1-2 from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism
Supplementary Figure 1 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
PDF file - 737KB, Supplemental Figure 1: Apoptosis antibody array result of Uacc903-V1 and -G2.
Supplementary Figure 3 from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
PDF file - 237KB, Supplemental Figure 3: Stable GRM1 knock-down cells lines were obtained by shRNA. 50% GRM1 protein level decrease in UACC9093-G4 cells dramatically decreased VEGF secretion, but 50% GRM1 protein level decrease in UACC903-…
Supplementary Figure Legends from Activation of the Glutamate Receptor GRM1 Enhances Angiogenic Signaling to Drive Melanoma Progression Open
PDF file - 42KB
Supplementary Materials, Figures 1-2 from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca<sup>2+</sup>-Dependent Mechanism Open
Supplementary Materials, Figures 1-2 from Exchange Protein Directly Activated by Cyclic AMP Increases Melanoma Cell Migration by a Ca2+-Dependent Mechanism