Sven Gläsker
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View article: CRISPR/Cas9-mediated editing of VHL in induced pluripotent stem cells: A model for early cell fate in von Hippel-Lindau syndrome
CRISPR/Cas9-mediated editing of VHL in induced pluripotent stem cells: A model for early cell fate in von Hippel-Lindau syndrome Open
View article: Genotype-specific neoplastic risk profiles in patients with VHL disease
Genotype-specific neoplastic risk profiles in patients with VHL disease Open
Hereditary tumor predisposition syndromes pose a challenge for early detection and timely treatment of tumors. In von Hippel–Lindau disease, desirable personalized surveillance programs are lacking due to insufficient data on genotype-spec…
View article: Optic nerve and chiasm hemangioblastomas in von Hippel-Lindau disease: report of 12 cases and review of the literature
Optic nerve and chiasm hemangioblastomas in von Hippel-Lindau disease: report of 12 cases and review of the literature Open
Introduction Optic nerve and chiasm hemangioblastomas are rare tumors, occurring sporadically or in the context of von Hippel-Lindau (VHL) disease. They have only been portrayed in isolated case reports and small cohorts. Their natural his…
View article: Expression of Hemangioblast Proteins in von Hippel-Lindau Disease Related Tumors
Expression of Hemangioblast Proteins in von Hippel-Lindau Disease Related Tumors Open
Von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome that targets a highly selective subset of organs causing specific types of tumors. The biological basis for this principle of organ selectivity and tumor specificity is not wel…
View article: Cumulative surgical morbidity in patients with multiple cerebellar and medullary hemangioblastomas
Cumulative surgical morbidity in patients with multiple cerebellar and medullary hemangioblastomas Open
Resection of multiple cerebellar hemangioblastomas is not associated with cumulative morbidity. Although there is a certain cumulative surgical morbidity caused by medullary surgeries, its extent does not increase with the number of perfor…
View article: Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment
Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment Open
View article: <p>Von Hippel-Lindau Disease: Current Challenges and Future Prospects</p>
Von Hippel-Lindau Disease: Current Challenges and Future Prospects Open
Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their …
View article: Von Hippel-Lindau Disease: Current Challenges and Future Prospects
Von Hippel-Lindau Disease: Current Challenges and Future Prospects Open
Sven Gläsker,1,2 Evelynn Vergauwen,2,3 Christian A Koch,4 Alexander Kutikov,4 Alexander O Vortmeyer5 1Neurosurgical Practise Lake Constance, Singen (Hohentwiel), Germany; 2Department of Neurosurgery, VUB University Medical Center Brus…
View article: Predictors of dopamine agonist resistance in prolactinoma patients
Predictors of dopamine agonist resistance in prolactinoma patients Open
Background Surgical resection of prolactinomas resistant to dopamine agonists is frequently incomplete due to fibrotic changes of the tumour under pharmacological therapy. In order to identify a subgroup of patients who may benefit from ea…
View article: A focused 35-minute whole body MRI screening protocol for patients with von Hippel-Lindau disease
A focused 35-minute whole body MRI screening protocol for patients with von Hippel-Lindau disease Open
View article: Polyglobulia in patients with hemangioblastomas is related to tumor size but not to serum erythropoietin
Polyglobulia in patients with hemangioblastomas is related to tumor size but not to serum erythropoietin Open
View article: Central nervous system gadolinium accumulation in patients undergoing periodical contrast MRI screening for hereditary tumor syndromes
Central nervous system gadolinium accumulation in patients undergoing periodical contrast MRI screening for hereditary tumor syndromes Open
View article: Supplementary Material for: Autosomal Dominant Polycystic Kidney Disease: Prevalence of Renal Neoplasias in Surgical Kidney Specimens
Supplementary Material for: Autosomal Dominant Polycystic Kidney Disease: Prevalence of Renal Neoplasias in Surgical Kidney Specimens Open
Background: The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence of RCC in ADPKD are limited, especially on a large pop…
View article: Characterization of endolymphatic sac tumors and von Hippel–Lindau disease in the International Endolymphatic Sac Tumor Registry
Characterization of endolymphatic sac tumors and von Hippel–Lindau disease in the International Endolymphatic Sac Tumor Registry Open
Background Endolymphatic sac tumors (ELSTs) are, with a prevalence of up to 16%, a component of von Hippel–Lindau (VHL) disease. Data from international registries regarding heritable fraction and characteristics, germline VHL mutation fre…