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View article: Downregulation of NONO Suppresses Proliferation, Migration, and Invasion in Metastatic Prostate Cancer
Downregulation of NONO Suppresses Proliferation, Migration, and Invasion in Metastatic Prostate Cancer Open
Background As prostate cancer (PCa) remains one of the leading causes of cancer‐related death in men, it is important to develop effective therapeutic approaches for the treatment of metastatic PCa and to improve the accuracy of prognosis …
View article: Corrigendum to “A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers” [Lung Cancer 199 (2025) 108060]
Corrigendum to “A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers” [Lung Cancer 199 (2025) 108060] Open
The authors wish to inform the readers that the correct authors list and affiliations of all the authors have been updated as above. The authors have identified an error in the legend of Figure 5. The legend should be replaced with “Figure…
View article: A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers
A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers Open
The modified classification demonstrates essentially higher reproducibility compared to the current WHO classification in NMA. The modified classification proves valuable in identifying low-risk lesions that are entirely non-invasive, and …
View article: Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas Open
Background We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). Methods We analyzed digitized H&E-stained slides from a multicenter cohort of five large univ…
View article: Comprehensive transcriptomic analysis of prostate cancer lung metastases
Comprehensive transcriptomic analysis of prostate cancer lung metastases Open
Metastatic prostate cancer (mPCa) is a widespread disease with high mortality. Unraveling molecular mechanisms of disease progression is of utmost importance. The microenvironment in visceral organs and the skeletal system is of particular…
View article: Prognostic and Clinical Heterogeneity of PD1 and PD-L1- Immunohistochemical Scores in Endometrial Cancers
Prognostic and Clinical Heterogeneity of PD1 and PD-L1- Immunohistochemical Scores in Endometrial Cancers Open
Introduction: PD1/PD-L1 inhibition (ICi) has recently become a new standard of care for patients with advanced MMR-deficient (MMRd) endometrial cancers. Nevertheless, response to immunotherapy is more complex than the presence of a single …
View article: CEACAM6 Promotes Lung Metastasis<i>via</i>Enhancing Proliferation, Migration and Suppressing Apoptosis of Prostate Cancer Cells
CEACAM6 Promotes Lung Metastasis<i>via</i>Enhancing Proliferation, Migration and Suppressing Apoptosis of Prostate Cancer Cells Open
Functional validation revealed that CEACAM6 might play an important role in fostering metastatic spread to the lung of PCa patients via enhancing proliferation, migration and suppressing apoptosis in PC-3 and LNCaP cells. CEACAM6 might pos…
View article: Proteomic analysis of the urothelial cancer landscape
Proteomic analysis of the urothelial cancer landscape Open
Urothelial bladder cancer (UC) has a wide tumor biological spectrum with challenging prognostic stratification and relevant therapy-associated morbidity. Most molecular classifications relate only indirectly to the therapeutically relevant…
View article: The F-actin bundler SWAP-70 promotes tumor metastasis
The F-actin bundler SWAP-70 promotes tumor metastasis Open
Dynamic rearrangements of the F-actin cytoskeleton are a hallmark of tumor metastasis. Thus, proteins that govern F-actin rearrangements are of major interest for understanding metastasis and potential therapies. We hypothesized that the u…
View article: ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription Open
Rationale: Current therapies for metastatic osseous disease frequently fail to provide a durable treatment response. To date, there are only limited therapeutic options for metastatic prostate cancer, the mechanisms that drive the survival…
View article: Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) Promotes Metastatic Spread to the Lung in Advanced Prostate Cancer
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6) Promotes Metastatic Spread to the Lung in Advanced Prostate Cancer Open
Prostate cancer (PCa) Lung metastases are rarely resected, therefore PCa lung metastases are insufficiently molecularly characterized. We recently identified carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) as a potential driver…
View article: EpCAM tumor specificity and proteoform patterns in urothelial cancer
EpCAM tumor specificity and proteoform patterns in urothelial cancer Open
Background The role of the epithelial cell adhesion molecule (EpCAM) in cancer is still unclear. EpCAM cleavage through regulated intramembrane proteolysis results in fragments which interact with both oncogenic and tumor suppressive pathw…
View article: Data Supplement from Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma
Data Supplement from Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma Open
Figure S1. Fluorescence in situ hybridization (FISH) analysis of FGFR1 gene copy number status in mesothelioma cell lines. Figure S2. Bioluminescence imaging of orthotopically implanted H226 tumors treated with or without ponatinib. Supple…
View article: Figure S5 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner
Figure S5 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner Open
S5. (a-e) µCT-based monitoring of KPE and KPE post cis allograft tumor response in KPE syngeneic mice (n = 4) prior to and after etoposide treatment (Mice 2-5 shown). Allograft tumors are marked with "T".
View article: Figure S1 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner
Figure S1 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner Open
S1.(a) Distribution of tumor vs. normal lung tissue in K, KE, KP and KPE mice at 4 weeks post tumor induction (top). Distribution of murine lung adenocarcinoma grades (G1, G2, G3) in corresponding K, KE, KP and KPE mice at 4 weeks post tum…
View article: Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
XLSX file 75K, This is an excel file containing 9 sheets, one for each of the 9 supplementary tables (S1 to S9) mentioned in the main text
View article: Data from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
Data from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets Open
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next-generation RNA sequencing and oligonucleotide arrays, we profiled 7 NEP…
View article: Data from Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma
Data from Nonamplified FGFR1 Is a Growth Driver in Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is associated with asbestos exposure and is a cancer that has not been significantly affected by small molecule-based targeted therapeutics. Previously, we demonstrated the existence of functional subse…
View article: Figure S4 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner
Figure S4 from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner Open
S4. (a) Representative immunostaining of Pt-(GpG) adducts in KP and KPE cell lines after cisplatin exposure (left). Quantification of Pt-(GpG) adduct staining in KP (n = 5) and KPE (n = 6) cells after cisplatin exposure (right). P values w…
View article: Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
PDF file 234K, This is a file containing the list of supplementary tables, the list of supplementary figures, as well as the 7 supplementary figures (S1 to S7) and their correspondent legends, mentioned in the main text
View article: Data from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner
Data from <i>Ercc1</i> Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a <i>Tp53</i> Context-Specific Manner Open
KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combi…
View article: Data from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
Data from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets Open
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next-generation RNA sequencing and oligonucleotide arrays, we profiled 7 NEP…