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View article: Cognitive impairment and associated neurobehavioral dysfunction in post-COVID syndrome
Cognitive impairment and associated neurobehavioral dysfunction in post-COVID syndrome Open
There is a high prevalence of neuropsychiatric sequelae in post-COVID syndrome, most commonly chronic fatigue, the mechanisms of which remain poorly understood. As altered function of the reward system has been suggested as a causal factor…
View article: Interim analysis of a post-authorization safety study of pitolisant in treating narcolepsy: A real-world European study
Interim analysis of a post-authorization safety study of pitolisant in treating narcolepsy: A real-world European study Open
Pitolisant was generally safe and well tolerated in patients with NT1 and NT2 and can be used in both types. Improvements were found in EDS, cataplexy, and quality of life, with good adherence and satisfaction.
View article: Corticosteroid‐responsive narcolepsy type <scp>II</scp> after <scp>COVID</scp> ‐19: A relevant differential diagnosis of post‐ <scp>COVID</scp> syndrome (a case report)
Corticosteroid‐responsive narcolepsy type <span>II</span> after <span>COVID</span> ‐19: A relevant differential diagnosis of post‐ <span>COVID</span> syndrome (a case report) Open
Summary Excessive daytime sleepiness is a possible symptom of post‐COVID syndrome and is also the cardinal symptom of narcolepsy, a rare life‐long sleep disorder with a possible autoimmune background. Recent reports indicate that COVID‐19 …
View article: Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study
Association between prenatal glucocorticoid exposure and adolescent neurodevelopment: An observational follow‐up study Open
Introduction Prenatal exposure to supraphysiological glucocorticoid (GC) levels may lead to long‐lasting developmental changes in numerous biological systems. Our prior study identified an association between prenatal GC prophylaxis and re…
View article: Symptomatic, Drug-Resistant Narcolepsy Remission After Fenestration of an Arachnoid Cyst – A Case Report
Symptomatic, Drug-Resistant Narcolepsy Remission After Fenestration of an Arachnoid Cyst – A Case Report Open
Symptomatic narcolepsy due to space-occupying lesions in the mesencephalon comprises a unique curative treatment option. Here, surgical intervention offers an effective curative therapeutic approach. However, differential diagnosis of symp…
View article: Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review
Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review Open
Pro-inflammatory state is related to an overall reduction in HRV rather than a singular reduction in vagally-mediated HRV indices, reflecting the complex autonomic-regulatory changes occurring during inflammation. The potential benefit of …
View article: A hypoarousal model of neurological post-COVID syndrome: the relation between mental fatigue, the level of central nervous activation and cognitive processing speed
A hypoarousal model of neurological post-COVID syndrome: the relation between mental fatigue, the level of central nervous activation and cognitive processing speed Open
Background Knowledge on the nature of post-COVID neurological sequelae often manifesting as cognitive dysfunction and fatigue is still unsatisfactory. Objectives We assumed that cognitive dysfunction and fatigue in post-COVID syndrome are …
View article: The Relationship Between Cognitive Impairments and Sleep Quality Measures in Persistent Insomnia Disorder
The Relationship Between Cognitive Impairments and Sleep Quality Measures in Persistent Insomnia Disorder Open
Using a simple neurocognitive screening tool, we found that pID patients showed cognitive deficiencies that related to both subjective/self-reported and objective/polysomnographic measures of sleep quality. Furthermore, these cognitive cha…
View article: Proposal of new clinical diagnostic criteria for fatal familial insomnia
Proposal of new clinical diagnostic criteria for fatal familial insomnia Open
Background Early and accurate diagnosis of fatal familial insomnia (FFI) is critical for effective screening; however, this rare disease remains difficult to recognize. This work aimed to propose a new diagnostic criterion for fatal famili…
View article: Neural distinctiveness of fatigue and low sleep quality in multiple sclerosis
Neural distinctiveness of fatigue and low sleep quality in multiple sclerosis Open
Background and purpose Fatigue and low sleep quality in multiple sclerosis (MS) are closely related symptoms. Here, the associations between the brain's functional connectivity (FC) and fatigue and low sleep quality were investigated to de…
View article: Association between antenatal glucocorticoid exposure and the activity of the stress system, cognition, and behavior in 8‐ to 9‐year‐old children: A prospective observational study
Association between antenatal glucocorticoid exposure and the activity of the stress system, cognition, and behavior in 8‐ to 9‐year‐old children: A prospective observational study Open
Introduction Glucocorticoid (GC) ‐induced fetal programming of the activity of the hypothalamus–pituitary–adrenal axis (HPAA) and its associated cognitive and behavioral consequences in later life have been well characterized in several an…
View article: Proposal of new diagnostic criteria for fatal familial insomnia
Proposal of new diagnostic criteria for fatal familial insomnia Open
Background The understanding of fatal familial insomnia (FFI), a rare neurodegenerative autosomal dominant prion disease, has improved in recent years as more cases were reported. This work aimed to propose new diagnostic criteria for FFI …
View article: Improvement of life quality due to hypoglossal nerve stimulation in a patient with duchenne muscular dystrophy – a case report of a rare form of therapy
Improvement of life quality due to hypoglossal nerve stimulation in a patient with duchenne muscular dystrophy – a case report of a rare form of therapy Open
In september 2016 the neurological sleep laboratory introduced us a 47 year old patient. The man didn´t ask us for an alternative treatment of his sleep apnea. He needed help because all the previously efforts of re-titration of his noctur…
View article: A 37-Year-Old Man With Structural Focal Epilepsy and Paroxysmal Nocturnal Breathing Arrests
A 37-Year-Old Man With Structural Focal Epilepsy and Paroxysmal Nocturnal Breathing Arrests Open
A 37-year-old male patient was referred to our sleep laboratory with suspected sleep-disordered breathing. His partner reported periods of breathing arrest accompanied by an odd expiratory noise during sleep, occurring on a near to weekly …
View article: Impact of antenatal glucocorticoid exposure on the activity of the stress system, cognition and behavior in 8 to 9-year-old children: a clinical cohort study
Impact of antenatal glucocorticoid exposure on the activity of the stress system, cognition and behavior in 8 to 9-year-old children: a clinical cohort study Open
Objective: To determine stress-sensitivity and neurodevelopmental outcome in 8- to 9-year-old children following antenatal exposure to glucocorticoid (GC) prophylaxis for neonatal respiratory distress syndrome. Design: Clinical cohort stud…
View article: Systematic quantitative assessment of motor function in clinically isolated REM sleep behaviour disorder: A diagnostic window into early alpha‐synucleinopathies
Systematic quantitative assessment of motor function in clinically isolated REM sleep behaviour disorder: A diagnostic window into early alpha‐synucleinopathies Open
Mild motor abnormalities can herald the beginning of Parkinson´s disease but their diagnostic value is limited by multifactorial ageing‐related influences on motor function. We characterized mild motor abnormalities in different motor doma…
View article: <i>To rout or snort in the sleepe</i>: a detailed medical description of sleep disordered breathing and its consequences by Georg Grau in 1688
<i>To rout or snort in the sleepe</i>: a detailed medical description of sleep disordered breathing and its consequences by Georg Grau in 1688 Open
Description of sleep disordered breathing and its consequences was made as early as the 17th century, including upper airway pathology during sleep, risk factors for SDB and medical consequences, simply based on detailed medical observatio…
View article: Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of α1-adrenergic signalling
Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of α1-adrenergic signalling Open
While the cerebral autoregulation sufficiently protects subcortical brain regions during hypoxia or asphyxia, the cerebral cortex is not as adequately protected, which suggests that regulation of the cerebral blood flow (CBF) is area-speci…
View article: Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of α1-Adrenergic Signaling
Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of α1-Adrenergic Signaling Open
Background: Maintenance of brain circulation during shock is sufficient to prevent subcortical injury but the cerebral cortex is not spared. This suggests area-specific regulation of cerebral blood flow (CBF) during hemorrhage. Methods: Co…
View article: Weather as a risk factor for epileptic seizures: A case‐crossover study
Weather as a risk factor for epileptic seizures: A case‐crossover study Open
Summary Objective Most epileptic seizures occur unexpectedly and independently of known risk factors. We aimed to evaluate the clinical significance of patients’ perception that weather is a risk factor for epileptic seizures. Methods Usin…
View article: Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: a prospective observational study
Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: a prospective observational study Open
Sleep disordered breathing (SDB) is common in patients with coronary disease, but its impact on post-operative recovery after coronary artery bypass graft surgery (CABG) is unclear. We therefore determined the effects of SDB on post-operat…