Sven Stringer
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Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways Open
Insomnia is the second most prevalent mental disorder, with no sufficient treatment available. Despite substantial heritability, insight into the associated genes and neurobiological pathways remains limited. Here, we use a large genetic a…
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk Open
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we …
View article: Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci Open
Background: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with substance use tr…
Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes Open
An enigma in studies of neuropsychiatric disorders is how to translate polygenic risk into disease biology. For schizophrenia, where > 145 significant GWAS loci have been identified and only a few genes directly implicated, addressing this…
A global overview of pleiotropy and genetic architecture in complex traits Open
After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics are still unanswered, such as the extent of pleiotropy across the genome, the nature of trait-associated genetic variants and the disparate …
MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission Open
The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated allele is reported to increase miR-137 expression and miR-137 overexpression alters synaptic transmission in mouse hippocampus. We investigated the…
A tutorial on conducting genome‐wide association studies: Quality control and statistical analysis Open
Objectives Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social science…
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease risk Open
Late onset Alzheimer’s disease (AD) is the most common form of dementia with more than 35 million people affected worldwide, and no curative treatment available. AD is highly heritable and recent genome-wide meta-analyses have identified o…
Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways Open
Insomnia is the second-most prevalent mental disorder, with no sufficient treatment available. Despite a substantial role of genetic factors, only a handful of genes have been implicated and insight into the associated neurobiological path…
Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use Open
Cannabis use is a heritable trait [1] that has been associated with adverse mental health outcomes. To identify risk variants and improve our knowledge of the genetic etiology of cannabis use, we performed the largest genome-wide associati…
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence Open
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to intelligence 3–7 , but much about its genetic underpinnings remains to…
GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways Open
Neuroticism is an important risk factor for psychiatric traits including depression 1 , anxiety 2,3 , and schizophrenia 4–6 . Previous genome-wide association studies 7–12 (GWAS) reported 16 genomic loci 10–12 . Here we report the largest …