Sven Wischnewski
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View article: Activated Dendritic Cell Subsets Characterize Muscle of Inclusion Body Myositis Patients and Correlate with KLRG1+ and TBX21+ CD8+ T cells
Activated Dendritic Cell Subsets Characterize Muscle of Inclusion Body Myositis Patients and Correlate with KLRG1+ and TBX21+ CD8+ T cells Open
Inclusion body myositis (IBM) is an idiopathic inflammatory myopathy characterized by muscle-infiltrating KLRG1+ and TBX21+ cytotoxic T cells and type 1 inflammation. Myeloid dendritic cells (mDCs), including type 1 conventional dendritic …
View article: Emerging mechanisms and therapeutics in inflammatory muscle diseases
Emerging mechanisms and therapeutics in inflammatory muscle diseases Open
Idiopathic inflammatory myopathies (IIMs), or myositis, are rare diseases marked by immune-driven muscle damage and complications like skin lesions and interstitial lung disease (ILD). Despite advances, challenges in diagnosis and treatmen…
View article: Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis Open
Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older adults with no effective therapy available. In contrast to other inflammatory myopathies such as subacute, immune-mediated necrotizing myopathy (IMNM)…
View article: Multifactorial White Matter Damage in the Acute Phase and Pre-Existing Conditions May Drive Cognitive Dysfunction after SARS-CoV-2 Infection: Neuropathology-Based Evidence
Multifactorial White Matter Damage in the Acute Phase and Pre-Existing Conditions May Drive Cognitive Dysfunction after SARS-CoV-2 Infection: Neuropathology-Based Evidence Open
Background: There is an urgent need to better understand the mechanisms underlying acute and long-term neurological symptoms after COVID-19. Neuropathological studies can contribute to a better understanding of some of these mechanisms. Me…
View article: Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19
Presence of SARS-CoV-2 Transcripts in the Choroid Plexus of MS and Non-MS Patients With COVID-19 Open
Although primarily targeting the respiratory system, coronavirus disease 2019 (COVID-19) affects the CNS in up to 80% of patients.[1][1] Yet, findings on COVID-19 neuropathology have been conflicting: autopsy reports range from inflammator…
View article: Gut microbiota–specific IgA <sup>+</sup> B cells traffic to the CNS in active multiple sclerosis
Gut microbiota–specific IgA <sup>+</sup> B cells traffic to the CNS in active multiple sclerosis Open
IgA + cells act as a systemic mediator between the gut and the central nervous system during active multiple sclerosis.