Svenja Hellmann
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View article: piRNA processing by a trimeric Schlafen-domain nuclease
piRNA processing by a trimeric Schlafen-domain nuclease Open
Transposable elements are genomic parasites that expand within and spread between genomes 1 . PIWI proteins control transposon activity, notably in the germline 2,3 . These proteins recognize their targets through small RNA co-factors name…
View article: piRNA processing by a trimeric Schlafen-domain nuclease
piRNA processing by a trimeric Schlafen-domain nuclease Open
Transposable elements are genomic parasites that expand within and spread between genomes 1 . Piwi proteins control transposon activity, notably in the germline 2,3 . These proteins recognize their targets through small RNA co-factors name…
View article: Intrinsically disordered protein PID‐2 modulates Z granules and is required for heritable piRNA‐induced silencing in the <i>Caenorhabditis elegans</i> embryo
Intrinsically disordered protein PID‐2 modulates Z granules and is required for heritable piRNA‐induced silencing in the <i>Caenorhabditis elegans</i> embryo Open
In Caenorhabditis elegans, the piRNA (21U RNA) pathway is required to establish proper gene regulation and an immortal germline. To achieve this, PRG-1-bound 21U RNAs trigger silencing mechanisms mediated by RNA-dependent RNA polymerase (R…
View article: The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo
The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo Open
In Caenorhabditis elegans , the piRNA (21U RNA) pathway is required to establish proper gene regulation and an immortal germline. To achieve this, PRG-1-bound 21U RNAs trigger silencing mechanisms mediated by RNA-dependent RNA polymerase (…
View article: PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability Open
Piwi proteins are important for germ cell development in most animals. These proteins are guided to specific targets by small guide RNAs, referred to as piRNAs or 21U RNAs in Caenorhabditis elegans . In this organism, even though genetic s…
View article: PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability Open
Piwi proteins are important for germ cell development in almost all animals studied thus far. These proteins are guided to specific targets, such as transposable elements, by small guide RNAs, often referred to as piRNAs, or 21U RNAs in C.…