Svenja Ulferts
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View article: SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II Open
The nucleoskeleton is essential for nuclear architecture as well as genome integrity and gene expression. In addition to lamins, titin or spectrins, dynamic actin filament polymerization has emerged as a potential intranuclear structural e…
View article: Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells
Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells Open
Actin network dynamics are pivotal in governing the motility and effector functions of immune cells. The Arp2/3 complex is a key regulator of actin filament branching, with mutations in its subunits being linked with human immunodeficienci…
View article: Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity
Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity Open
View article: Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation Open
View article: Replication fork plasticity upon replication stress requires rapid nuclear actin polymerization
Replication fork plasticity upon replication stress requires rapid nuclear actin polymerization Open
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown. Using nuclear actin probes i…
View article: Vesicle‐Associated Actin Assembly by Formins Promotes TGF<i>β</i>‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023)
Vesicle‐Associated Actin Assembly by Formins Promotes TGF<i>β</i>‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion (Adv. Sci. 9/2023) Open
Actin Dynamics In article number 2204896, a novel role of the formin FMNL2 is uncovered by Dennis Frank, Christel Jessica Moussi, Carsten Schwan, Robert Grosse, and co‐workers. TGFβ‐induced processes, such as cell invasion and the secretio…
View article: Vesicle‐Associated Actin Assembly by Formins Promotes TGF<i>β</i>‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion
Vesicle‐Associated Actin Assembly by Formins Promotes TGF<i>β</i>‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion Open
Vesicle trafficking has emerged as an important process driving tumor progression through various mechanisms. Transforming growth factor beta (TGF β )‐mediated secretion of Angiopoietin‐like 4 (ANGPTL4) is important for cancer development.…
View article: Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A
Filamentous nuclear actin regulation of PML NBs during the DNA damage response is deregulated by prelamin A Open
Nuclear actin participates in a continuously expanding list of core processes within eukaryotic nuclei, including the maintenance of genomic integrity. In response to DNA damage, nuclear actin polymerises into filaments that are involved i…
View article: Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation Open
The formation of biomolecular condensates underpins many cellular processes; however, our current understanding of condensate formation within cells is largely based on observing the final near-equilibrium condensate state. It is less clea…
View article: Filamentous nuclear actin regulation of PML-NBs during the DNA damage response is deregulated by prelamin A
Filamentous nuclear actin regulation of PML-NBs during the DNA damage response is deregulated by prelamin A Open
Nuclear actin participates in a continuously expanding list of core processes within eukaryotic nuclei including the maintenance of genomic integrity. In response to DNA damage, nuclear actin polymerises into filaments that are involved in…
View article: Antibody escape and global spread of SARS-CoV-2 lineage A.27
Antibody escape and global spread of SARS-CoV-2 lineage A.27 Open
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeo…
View article: Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants Open
View article: Antibody escape and global spread of SARS-CoV-2 lineage A.27
Antibody escape and global spread of SARS-CoV-2 lineage A.27 Open
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeo…
View article: Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient: a source of immune escape variants
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient: a source of immune escape variants Open
The recent emergence of SARS-CoV-2 variants showing increased transmissibility and immune escape is a matter of global concern. Their origin remains unclear, but intra-host virus evolution during persistent infections could be a contributi…
View article: Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus
Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus Open
Recent years have provided considerable insights into the dynamic nature of the cell nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well as spatiotemporally orchestrating chromatin remodeling and t…
View article: Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms Open
How lethal coronaviruses engage hosts Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts …
View article: Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis Open
View article: The Global Phosphorylation Landscape of SARS-CoV-2 Infection
The Global Phosphorylation Landscape of SARS-CoV-2 Infection Open
View article: The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Bouhaddou et al., 2020.
The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Bouhaddou et al., 2020. Open
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need …