Sverre Lehmann
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View article: No association between obstructive sleep apnea and restless legs syndrome: results from a large hospital-based cross-sectional study
No association between obstructive sleep apnea and restless legs syndrome: results from a large hospital-based cross-sectional study Open
Introduction Some studies have indicated a possible association between obstructive sleep apnea (OSA) and restless legs syndrome (RLS). Our aim was to explore this association in a large sample of patients referred to a hospital for suspec…
View article: Overcoming an underdiagnosed respiratory condition: should more patients with cardiovascular complications be screened for obstructive sleep apnea?
Overcoming an underdiagnosed respiratory condition: should more patients with cardiovascular complications be screened for obstructive sleep apnea? Open
Early screening and detection are crucial, given the strong association between untreated OSA and adverse health outcomes. Expert consensus recommends routine OSA screening in high-risk cardiovascular populations and emphasizes comprehensi…
View article: Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls
Inflammatory cells and remodeling in bronchial biopsies from COPD patients and controls Open
Background The understanding of inflammation and remodeling in the bronchial wall of COPD patients with varying disease severity remains incomplete. Methods 35 healthy controls and 47 volunteer COPD patients underwent bronchoscopy with bro…
View article: Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data
Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data Open
Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.
View article: International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update
International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update Open
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As the first global registry for adults with severe asthma,…
View article: Oral Health Related Factors Predicting Severe <scp>COVID</scp>‐19 Disease in Elderly Swedes
Oral Health Related Factors Predicting Severe <span>COVID</span>‐19 Disease in Elderly Swedes Open
Objectives To analyse different background factors that may serve as predictors for acquiring symptoms of severe COVID‐19 disease. Methods A postal questionnaire was sent to the total population of individuals born between 1942 (80 years, …
View article: Elastic Bands Improve Oral Appliance Treatment Effect on Obstructive Sleep Apnoea: A Randomised Crossover Trial
Elastic Bands Improve Oral Appliance Treatment Effect on Obstructive Sleep Apnoea: A Randomised Crossover Trial Open
Background Oral appliances (OAs) that limit mouth opening during sleep, such as monobloc appliances, have shown superior treatment effects in subgroups of patients with obstructive sleep apnoea. The application of elastic bands on bibloc a…
View article: Lower airway microbiota in COPD and healthy controls
Lower airway microbiota in COPD and healthy controls Open
Background The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared with the microbiota in healthy individuals. Information on how the microbiota is affected by smoking, use of i…
View article: General and orofacial symptoms associated with acute and long COVID in 80- and 90-year-old Swedish COVID-19 survivors
General and orofacial symptoms associated with acute and long COVID in 80- and 90-year-old Swedish COVID-19 survivors Open
Long-COVID general and orofacial symptoms are common among older elderly COVID-19 survivors CLINICAL SIGNIFICANCE: Oral microorganisms may be responsible for development of long-COVID symptoms. Health personnel managing COVID-19 patients s…
View article: Association between Covid-19 infection and platypnea–orthodeoxia syndrome
Association between Covid-19 infection and platypnea–orthodeoxia syndrome Open
Introduction and importance: Platypnea–orthodeoxia syndrome is defined as dyspnoea and deoxygenation when changing from a recumbent to an upright position. Post-Covid-19 sequelae can induce or exacerbate pulmonary hypertension and thereby …
View article: Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study
Prevalence and impact of exercise-induced laryngeal obstruction in asthma: a study protocol for a cross-sectional and longitudinal study Open
Introduction Exercise-induced laryngeal obstruction (EILO) and exercise-induced asthma can cause troublesome respiratory symptoms that can be difficult to distinguish between. Further, there is now a growing appreciation that the two condi…
View article: Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy
Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy Open
These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction.
View article: Comparative effectiveness of <scp>anti‐IL5</scp> and <scp>anti‐IgE</scp> biologic classes in patients with severe asthma eligible for both
Comparative effectiveness of <span>anti‐IL5</span> and <span>anti‐IgE</span> biologic classes in patients with severe asthma eligible for both Open
Background Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma…
View article: Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort Open
Background Real-life evidence on prevalence and management of severe asthma is limited. Nationwide population registries across the Nordic countries provide unique opportunities to describe prevalence and management patterns of severe asth…
View article: Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in severe asthma patients eligible for both
Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in severe asthma patients eligible for both Open
Background Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of severe adult asthma patients elig…
View article: Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy
Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy Open
Around one third of severe HOCS asthma patients did not receive biologics despite a similar high burden of asthma exacerbations as those who initiated a biologic therapy. Other disease characteristics such as eosinophilic phenotype, seriou…
View article: Clinical information predicting severe obstructive sleep apnea: A cross-sectional study of patients waiting for sleep diagnostics
Clinical information predicting severe obstructive sleep apnea: A cross-sectional study of patients waiting for sleep diagnostics Open
Based on a prediction score derived from simple, easily available data, patients unlikely to suffer from severe OSA can be identified, and thus facilitate more urgent consideration of patients more likely to have severe OSA.
View article: Association of Excessive Sleepiness, Pathological Fatigue, Depression, and Anxiety With Different Severity Levels of Obstructive Sleep Apnea
Association of Excessive Sleepiness, Pathological Fatigue, Depression, and Anxiety With Different Severity Levels of Obstructive Sleep Apnea Open
Objective The aim of this study was to investigate possible associations between obstructive sleep apnea and fatigue. This naturally led to considering the association between OSA and excessive sleepiness, depression, and anxiety. Backgrou…
View article: Characteristics of hypertension and arterial stiffness in obstructive sleep apnea: A Scandinavian experience from a prospective study of 6408 normotensive and hypertensive patients
Characteristics of hypertension and arterial stiffness in obstructive sleep apnea: A Scandinavian experience from a prospective study of 6408 normotensive and hypertensive patients Open
The impact of obstructive sleep apnea (OSA) on arterial stiffness is less studied. We aimed to investigate the prevalence and covariates of increased pulse pressure (PP), a surrogate marker of arterial stiffness, in the entire study popula…
View article: The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease Open
Background The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and proteins in idiopath…
View article: Effect of Continuous Positive Airway Pressure on Symptoms and Prevalence of Insomnia in Patients With Obstructive Sleep Apnea: A Longitudinal Study
Effect of Continuous Positive Airway Pressure on Symptoms and Prevalence of Insomnia in Patients With Obstructive Sleep Apnea: A Longitudinal Study Open
Objective Obstructive sleep apnea (OSA) and insomnia are the two most common sleep disorders. Continuous positive airway pressure (CPAP) is considered first-line treatment for OSA. In the present study, we assess the effect of CPAP on symp…
View article: Acoustic pharyngometry ‐ A new method to facilitate oral appliance therapy
Acoustic pharyngometry ‐ A new method to facilitate oral appliance therapy Open
Background There is lack of reliable and accurate methods to predict treatment outcomes of oral appliance (OA) treatment. Acoustic pharyngometry (AP) is a non‐invasive technique to evaluate the volume and minimal cross‐sectional area of th…