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View article: Analysis of metabolic liver function and MR-morphological cholestatic parameters after SBRT of liver metastases
Analysis of metabolic liver function and MR-morphological cholestatic parameters after SBRT of liver metastases Open
Background This study examined the longitudinal changes in metabolic liver function and MR-morphological dilatation of intrahepatic bile ducts in patients with stereotactic body radiation therapy (SBRT) for liver metastases. Methods This r…
View article: Optimizing cardiorespiratory fitness after bariatric surgery – highly effective with very low adherence: HIT BAR randomized controlled trial
Optimizing cardiorespiratory fitness after bariatric surgery – highly effective with very low adherence: HIT BAR randomized controlled trial Open
Background Cardiovascular disease and obesity-related comorbidities are key factors addressed by metabolic-bariatric surgery (MBS). Although High intensity interval training (HIIT) has been proven effective in healthy cohorts, limited evid…
View article: Correction: Comparison of T-POD and SAM Pelvic Sling II and the influence of attachment level in the initial management of unstable pelvic type C injuries – a cadaveric study
Correction: Comparison of T-POD and SAM Pelvic Sling II and the influence of attachment level in the initial management of unstable pelvic type C injuries – a cadaveric study Open
View article: Optimizing Cardiorespiratory Fitness after Bariatric Surgery – Highly Effective with very low Adherence: HIT BAR Randomized Controlled Trial
Optimizing Cardiorespiratory Fitness after Bariatric Surgery – Highly Effective with very low Adherence: HIT BAR Randomized Controlled Trial Open
(1) Background: Cardiovascular disease and obesity-related comorbidities are key factors addressed by metabolic-bariatric surgery (MBS). Although High intensity interval training (HIIT) has been proven effective in healthy cohorts, limited…
View article: Measurements of Lung Size in Ultrasound and Magnetic Resonance Imaging in Congenital Diaphragmatic Hernia – A Comparison of Prenatal Imaging Techniques
Measurements of Lung Size in Ultrasound and Magnetic Resonance Imaging in Congenital Diaphragmatic Hernia – A Comparison of Prenatal Imaging Techniques Open
To investigate the correlation between different prenatal imaging techniques in congenital diaphragmatic hernia (CDH) and their prognostic value. 209 fetuses with CDH were enrolled in this retrospective cohort study. The prenatal ultrasoun…
View article: Circulating collagen breakdown products as a biomarker for presence and instability of human intracranial aneurysms
Circulating collagen breakdown products as a biomarker for presence and instability of human intracranial aneurysms Open
Introduction: There is an unmet need for improved detection of intracranial aneurysms (IAs) and distinction between stable and unstable (high rupture risk) IAs. Within the IA wall, synthesis and degradation of type I collagen as the main m…
View article: Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy
Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy Open
Aims Cardiac implantable electrical devices such as cardiac resynchronization therapy with defibrillator (CRT‐Ds) or cardiac contractility modulation (CCMs) are therapy options for patients with symptomatic heart failure (HF) and reduced l…
View article: Cardiac Resynchronization Therapy with Defibrillator in Ischemic Versus Nonischemic Cardiomyopathy
Cardiac Resynchronization Therapy with Defibrillator in Ischemic Versus Nonischemic Cardiomyopathy Open
Cardiac resynchronization therapy with implantable cardioverter defibrillators (CRT-Ds) are established therapy options for patients suffering from heart failure (HF). Several aspects of HF modification have yet to be described regarding e…
View article: Acoustic Speech Analysis in Alzheimer's Disease: A Systematic Review and Meta-Analysis
Acoustic Speech Analysis in Alzheimer's Disease: A Systematic Review and Meta-Analysis Open
Although a small number of acoustic parameters on continuous speech could be evaluated in the detection of clinical AD, the greatest potential of acoustic biomarkers for AD appeared to exist in two of three categories. Further contribution…
View article: Robotic versus laparoscopic hepatectomy for liver malignancies (ROC'N'ROLL): a single-centre, randomised, controlled, single-blinded clinical trial
Robotic versus laparoscopic hepatectomy for liver malignancies (ROC'N'ROLL): a single-centre, randomised, controlled, single-blinded clinical trial Open
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View article: Long-Term Renal Function with Cardiac Contractility Modulation Therapy
Long-Term Renal Function with Cardiac Contractility Modulation Therapy Open
Background: Cardiac implantable electrical devices are able to affect kidney function through hemodynamic improvements. The Cardiac Contractility Modulation (CCM) is a device-based therapy option for patients with symptomatic chronic heart…
View article: Myeloid-derived suppressor cells in peripheral blood as predictive biomarkers in patients with solid tumors undergoing immune checkpoint therapy: systematic review and meta-analysis
Myeloid-derived suppressor cells in peripheral blood as predictive biomarkers in patients with solid tumors undergoing immune checkpoint therapy: systematic review and meta-analysis Open
Background Immunotherapeutic approaches, including immune checkpoint inhibitor (ICI) therapy, are increasingly recognized for their potential. Despite notable successes, patient responses to these treatments vary significantly. The absence…
View article: One- vs. Two-Stage Revision for Periprosthetic Shoulder Infections: A Systematic Review and Meta-Analysis
One- vs. Two-Stage Revision for Periprosthetic Shoulder Infections: A Systematic Review and Meta-Analysis Open
Periprosthetic shoulder infection (PSI) remains a challenging complication after shoulder arthroplasty. Therapeutic options include one- or two-stage revision, irrigation and debridement, and resection arthroplasty. With our systematic rev…
View article: Rifampin-resistant periprosthetic joint infections are associated with worse functional outcome in both acute and chronic infection types
Rifampin-resistant periprosthetic joint infections are associated with worse functional outcome in both acute and chronic infection types Open
Periprosthetic joint infections (PJI) pose a significant challenge in orthopaedic surgery, often requiring extensive surgical debridement and prolonged antibiotic treatment to eliminate the causative pathogens. Rifampin, known for its pote…
View article: Pleural Effusion and Chylothorax in Congenital Diaphragmatic Hernia—Risk Factors, Management and Outcome
Pleural Effusion and Chylothorax in Congenital Diaphragmatic Hernia—Risk Factors, Management and Outcome Open
Background: Pleural effusion and chylothorax are common complications in the treatment of congenital diaphragmatic hernia (CDH). We set out to identify risk factors for chylothorax development in patients with CDH and to investigate the as…
View article: Comparison of T-POD and SAM Pelvic Sling II and the influence of attachment level in the initial management of unstable pelvic type C injuries – a cadaveric study
Comparison of T-POD and SAM Pelvic Sling II and the influence of attachment level in the initial management of unstable pelvic type C injuries – a cadaveric study Open
Background Type C pelvic fractures (AO/OTA) are severe injuries that frequently lead to bleeding and hemodynamic instability. Pelvic binders play a crucial role in their initial management. Placement at the correct level in the prehospital…
View article: Case fatality and functional outcome after spontaneous subarachnoid haemorrhage: A systematic review and meta-analysis of time trends and regional variations in population-based studies
Case fatality and functional outcome after spontaneous subarachnoid haemorrhage: A systematic review and meta-analysis of time trends and regional variations in population-based studies Open
Introduction: A previous systematic review of population-based studies from 1973 to 2002 found a decrease in case fatality for spontaneous subarachnoid haemorrhage, but could not find a sufficient number of studies to assess changes in fun…
View article: Unraveling a Histopathological Needle-in-Haystack Problem: Exploring the Challenges of Detecting Tumor Budding in Colorectal Carcinoma Histology
Unraveling a Histopathological Needle-in-Haystack Problem: Exploring the Challenges of Detecting Tumor Budding in Colorectal Carcinoma Histology Open
Background: In this study focusing on colorectal carcinoma (CRC), we address the imperative task of predicting post-surgery treatment needs by identifying crucial tumor features within whole slide images of solid tumors, analogous to locat…
View article: Oncological right hemicolectomy in a trimodal comparison: open surgery versus laparoscopic procedures with extra- and intracorporeal anastomosis technique
Oncological right hemicolectomy in a trimodal comparison: open surgery versus laparoscopic procedures with extra- and intracorporeal anastomosis technique Open
Purpose This study aimed to investigate the surgical short- and mid-term outcomes, as well as the impact on quality of life and recovery, following oncological right hemicolectomy. To accomplish this, three patient cohorts were examined, w…
View article: Supplementary Material for: Flow cytometric characterization of HSPC subpopulations in autologous PBSC preparations after cryopreservation
Supplementary Material for: Flow cytometric characterization of HSPC subpopulations in autologous PBSC preparations after cryopreservation Open
Introduction: Autologous stem cell transplantation is a successful routine procedure with only a small number of non-engraftment cases, although the time to hematopoietic recovery may vary considerably across patients. While CD34 has been …
View article: The role of Vitamin D for incidence of and mortality after aneurysmal subarachnoid hemorrhage
The role of Vitamin D for incidence of and mortality after aneurysmal subarachnoid hemorrhage Open
View article: Robotic Versus Laparoscopic Hepatectomy for Liver Malignancies (ROC'N'ROLL): A Randomised Controlled Trial
Robotic Versus Laparoscopic Hepatectomy for Liver Malignancies (ROC'N'ROLL): A Randomised Controlled Trial Open
View article: Cemented versus Cementless Stem Fixation in Revision Total Knee Arthroplasty: A Systematic Review and Meta-Analysis
Cemented versus Cementless Stem Fixation in Revision Total Knee Arthroplasty: A Systematic Review and Meta-Analysis Open
The number of revision knee arthroplasties (rTKA) is growing significantly as is the use of intramedullary stems for optimized stability. The choice of the most appropriate stem fixation method is still controversial. The purpose of this m…
View article: Long-term outcomes from upgrade to cardiac resynchronisation therapy in ischaemic versus non-ischaemic heart disease
Long-term outcomes from upgrade to cardiac resynchronisation therapy in ischaemic versus non-ischaemic heart disease Open
Cardiac resynchronisation therapy (CRT) can be necessary in patients with chronic heart failure, who have already been provided with transvenous cardiac implantable electrical devices. Upgrade procedures revealed controversial results, whi…
View article: A Multi-Disciplinary MRI Assessment May Optimize the Evaluation of Chondral Lesions in Acute Ankle Fractures: A Prospective Study
A Multi-Disciplinary MRI Assessment May Optimize the Evaluation of Chondral Lesions in Acute Ankle Fractures: A Prospective Study Open
Chondral lesions (CL) in the ankle following acute fractures are frequently overlooked immediately after the injury or diagnosed at a later stage, leading to persistent symptoms despite successful surgery. The literature presents a wide ra…
View article: aCGH Analysis Reveals Novel Mutations Associated with Congenital Diaphragmatic Hernia Plus (CDH+)
aCGH Analysis Reveals Novel Mutations Associated with Congenital Diaphragmatic Hernia Plus (CDH+) Open
Congenital diaphragmatic hernia (CDH) is a major birth anomaly that often occurs with additional non-hernia-related malformations, and is then referred to as CDH+. While the impact of genetic alterations does not play a major role in isola…
View article: Surface guidance compared with ultrasound-based monitoring and diaphragm position in cone-beam computed tomography during abdominal stereotactic radiotherapy in breath-hold
Surface guidance compared with ultrasound-based monitoring and diaphragm position in cone-beam computed tomography during abdominal stereotactic radiotherapy in breath-hold Open
Residual motion detected during spirometry induced DIBH is small. SGRT alone is no sufficient surrogate for residual internal motion in all patients as some high velocity motion could not be detected. Observed patient-specific residual err…
View article: Stereotactic Body Radiation Therapy versus Surgical Resection for Stage I/II Hepatocellular Carcinoma
Stereotactic Body Radiation Therapy versus Surgical Resection for Stage I/II Hepatocellular Carcinoma Open
SBRT is an emerging locoregional treatment modality for hepatocellular carcinoma (HCC). Although local tumor control rates seem encouraging, large-scale survival data comparing SBRT to surgical resection are lacking. We identified patients…
View article: Abstract DGT
Abstract DGT Open
Background:The number of chest x-rays that are performed in the perioperative window of general thoracic surgery varies.Many clinics x-ray patients daily while others only perform x-rays if there are clinical concerns.The purpose of this s…
View article: Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients
Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients Open
Purpose Although the treatment of advanced melanoma patients with immune checkpoint inhibitors (ICI) significantly increased the therapeutic efficiency, many patients remain resistant to ICI that could be due to immunosuppression mediated …