Svetolik Spasić
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View article: The importance of measuring the levels of ionized magnesium in the blood in critically ill patients
The importance of measuring the levels of ionized magnesium in the blood in critically ill patients Open
Background: Critical illnesses imply vital organ dysfunctions with high risk of imminent death. Magnesium is a bioessential element with multiple physiological effects relevant for vital body functions. It stabilizes excitable membranes co…
View article: Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea Open
Sensorineural hearing loss (SNHL) is caused by damage to the mechanosensory hair cells and auditory neurons of the cochlea. The development of imaging tools that can directly visualize or provide functional information about a patient’s co…
View article: The impact of 2,4-diaminobutyric acid on proteins involved in the development of morphometrically measurable eye parameters in zebrafish: An in silico analysis
The impact of 2,4-diaminobutyric acid on proteins involved in the development of morphometrically measurable eye parameters in zebrafish: An in silico analysis Open
Introduction: 2,4-Diaminobutyric acid (2,4-DABA) is an excitatory amino acid with neurotoxic, hepatotoxic, and potentially carcinogenic effects, found in aquatic ecosystems with a tendency to accumulate in plants and animals. Due to its po…
View article: Genetic Discovery Enabled by A Large Language Model
Genetic Discovery Enabled by A Large Language Model Open
Artificial intelligence (AI) has been used in many areas of medicine, and recently large language models (LLMs) have shown potential utility for clinical applications. However, since we do not know if the use of LLMs can accelerate the pac…
View article: Revising the role of magnesium in epilepsy research and management
Revising the role of magnesium in epilepsy research and management Open
Magnesium is a bioessential mineral with multiple neuroactive effects. Mg2+ ion stabilizes excitable membranes. Epilepsy is the third most frequent chronic neurological condition characterized by spontaneous reappearance of unprovoked epil…
View article: Effects of KCa channel activator NS1619 on parameters оf Ni2+-induced epileptiform activity of leech Retzius neurons
Effects of KCa channel activator NS1619 on parameters оf Ni2+-induced epileptiform activity of leech Retzius neurons Open
View article: MO082THE EFFECTS OF DIFFERENT MICROMOLAR CONCENTRATIONS OF CADMIUM IONS ON THE PERITUBULAR MEMBRANE POTENTIAL OF PROXIMAL TUBULAR CELLS IN PERFUSED FROG KIDNEYS
MO082THE EFFECTS OF DIFFERENT MICROMOLAR CONCENTRATIONS OF CADMIUM IONS ON THE PERITUBULAR MEMBRANE POTENTIAL OF PROXIMAL TUBULAR CELLS IN PERFUSED FROG KIDNEYS Open
Background and Aims Cadmium (Cd2+) is toxic metal and environmental pollutant. Accumulation of cadmium in the kidney results initially in proximal tubule dysfunction. Although Cd2+ toxicity is well documented, all mechanisms that are invol…
View article: Erector Spinae Plane Block and Placement of Perineural Catheter for Developmental Hip Disorder Surgery in Children
Erector Spinae Plane Block and Placement of Perineural Catheter for Developmental Hip Disorder Surgery in Children Open
The ultrasound-guided erector spinae plane (ESP) block is a novel interfascial
\nplane block technique providing analgesic effects in different localizations of the body, in accordance
\nwith the level of administration. Although ESP block…
View article: The Fractal and GLCM Textural Parameters of Chromatin May Be Potential Biomarkers of Papillary Thyroid Carcinoma in Hashimoto's Thyroiditis Specimens
The Fractal and GLCM Textural Parameters of Chromatin May Be Potential Biomarkers of Papillary Thyroid Carcinoma in Hashimoto's Thyroiditis Specimens Open
Occasionally, Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) share similar nuclear features. The current study aims to quantify the differences between the investigated specimens of HT-associated PTC versus the HT alone…
View article: EXTENSIVE EXCITATORY EFFECTS OF 2,4 - DIAMINOBUTYRIC ACID ON LEECH RETZIUS NEURONS
EXTENSIVE EXCITATORY EFFECTS OF 2,4 - DIAMINOBUTYRIC ACID ON LEECH RETZIUS NEURONS Open
This study investigated the effect of L-arginine on blood pressure, angiogenic factors and liver enzymes in pregnant rats administered L-NAME. Thirty-six female Sprague-Dawley rats weighing between 150–170 g were divided into 4 groups of t…
View article: Antiepileptic magnesium effect
Antiepileptic magnesium effect Open
Magnesium is a bioessential mineral. Magnesium ion is an important regulator of multiple ion channels' function. Magnesium has many neuroactive effects at cellular, network and whole body level. Magnesium shows stabilizing effects on elect…
View article: Effect of low potassium concentration on cadmium induced epileptiform activity of leech retzius neurons
Effect of low potassium concentration on cadmium induced epileptiform activity of leech retzius neurons Open
Epilepsies have a large significance and require detailed investigation of cellular mechanisms that lead to this disorder. Environmental, especially industrial, toxins are having increasingly more prominent role in these investigations. Th…