Svilen Veselinov Georgiev
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View article: Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle
Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle Open
Synaptic transmission is driven by a complex cycle of vesicle docking, release, and recycling, maintained by distinct vesicle pools. However, the partitioning of vesicle pools and reserve pool recruitment remain poorly understood. We use a…
View article: One-step nanoscale expansion microscopy reveals individual protein shapes
One-step nanoscale expansion microscopy reveals individual protein shapes Open
View article: The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function Open
The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter‐loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo‐ and…
View article: PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis
PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis Open
Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of t…
View article: The long-loop recycling (LLR) of synaptic components as a question of economics
The long-loop recycling (LLR) of synaptic components as a question of economics Open
The pre- and post-synaptic compartments contain a variety of molecules that are known to recycle between the plasma membrane and intracellular organelles. The recycling steps have been amply described in functional terms, with, for example…
View article: Visualizing proteins by expansion microscopy
Visualizing proteins by expansion microscopy Open
Fluorescence imaging is one of the most versatile and widely-used tools in biology 1 . Although techniques to overcome the diffraction barrier were introduced more than two decades ago, and the nominal attainable resolution kept improving …
View article: Microglia sense neuronal activity via GABA in the early postnatal hippocampus
Microglia sense neuronal activity via GABA in the early postnatal hippocampus Open
Microglia, the resident macrophages in the central nervous system, express receptors for classical neurotransmitters, such as γ-aminobutyric acid (GABA) and glutamate, suggesting that they sense synaptic activity. To detect microglial Ca
View article: Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring Open
View article: Autophagy-dependent filopodial kinetics restrict synaptic partner choice during <i>Drosophila</i> brain wiring
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during <i>Drosophila</i> brain wiring Open
Summary Brain wiring is remarkably precise, yet most neurons readily form synapses with incorrect partners when given the opportunity. Dynamic axon-dendritic positioning can restrict synaptogenic encounters, but the spatiotemporal interact…