Swaminathan Ramasubramanian
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View article: Implications of the gut microbiome in spinal cord injuries
Implications of the gut microbiome in spinal cord injuries Open
Spinal cord injuries (SCIs) present complex challenges in medical treatment and rehabilitation, profoundly affecting the patient's physiological and neurological status. Emerging research on the gut microbiome has unveiled its potential ro…
View article: Vaginal Anaplastic Lymphoma Kinase (ALK)-Positive Mesenchymal Tumor in a Young Patient: Expanding the Spectrum of Rare Genitourinary Neoplasms
Vaginal Anaplastic Lymphoma Kinase (ALK)-Positive Mesenchymal Tumor in a Young Patient: Expanding the Spectrum of Rare Genitourinary Neoplasms Open
Primary vaginal tumors are uncommon, and mesenchymal neoplasms in this location are even rarer, often resembling benign lesions such as fibroids or cysts. We present the case of a 20-year-old woman with a steadily enlarging anterior vagina…
View article: Antimicrobial Effects of Platelet-Rich Plasma and Platelet-Rich Fibrin: A Scoping Review
Antimicrobial Effects of Platelet-Rich Plasma and Platelet-Rich Fibrin: A Scoping Review Open
View article: Evaluating Virtual Reality Interventions for Chronic Pain Management in Older Adults
Evaluating Virtual Reality Interventions for Chronic Pain Management in Older Adults Open
Background: Chronic pain significantly impairs the quality of life in older adults, with current treatments often being inadequate or accompanied by side effects. Virtual reality (VR) is emerging as a promising non-pharmacological interven…
View article: Precision Medicine in Orthobiologics: A Paradigm Shift in Regenerative Therapies
Precision Medicine in Orthobiologics: A Paradigm Shift in Regenerative Therapies Open
The evolving paradigm of precision medicine is redefining the landscape of orthobiologic therapies by moving beyond traditional diagnosis-driven approaches toward biologically tailored interventions. This review synthesizes current evidenc…
View article: Benign Vulval Leiomyoma: Report of a Rare Case
Benign Vulval Leiomyoma: Report of a Rare Case Open
View article: Comparative outcome analyses of subchondral <i>vs</i> intra-articular bone marrow aspirate concentrate in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol
Comparative outcome analyses of subchondral <i>vs</i> intra-articular bone marrow aspirate concentrate in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol Open
BACKGROUND Knee osteoarthritis (OA) imposes a substantial burden through pain, functional limitation, and progressive cartilage loss. Bone marrow aspirate concentrate (BMAC) has emerged as a promising regenerative therapy for OA due to its…
View article: Comparative outcome analyses of stromal vascular fraction <i>vs</i> nanofat in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol
Comparative outcome analyses of stromal vascular fraction <i>vs</i> nanofat in primary osteoarthritis knee: A double-blinded randomized controlled trial protocol Open
BACKGROUND Osteoarthritis (OA) of the knee is a prevalent degenerative joint disease that significantly impairs quality of life and functional mobility. Emerging regenerative therapies, such as stromal vascular fraction (SVF) and nanofat, …
View article: Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study
Safety and efficacy of autologous bone marrow aspirate concentrate injection for idiopathic male infertility: A comparative study Open
BACKGROUND Although limited clinical evidence exists, such as case reports of azoospermia treatment in humans using bone marrow aspirate concentrate (BMAC) injection, these findings provide a compelling foundation for exploring mesenchymal…
View article: Insights of cartilage imaging in cartilage regeneration
Insights of cartilage imaging in cartilage regeneration Open
Cartilage, as a specialized connective tissue, underpins joint mobility and mechanical load distribution while exhibiting inherently limited self-repair capabilities. This comprehensive review redefines the current landscape of cartilage i…
View article: Intra-articular Hyaluronic Acid Injections May Be Beneficial in Patients with Less Advanced Knee Osteoarthritis: A Systematic Review of Randomised Controlled Trials
Intra-articular Hyaluronic Acid Injections May Be Beneficial in Patients with Less Advanced Knee Osteoarthritis: A Systematic Review of Randomised Controlled Trials Open
View article: Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine
Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine Open
Stromal vascular fraction (SVF) therapy is a promising regenerative medicine strategy derived from adipose tissue, containing a heterogeneous mix of cells, including adipose-derived stem, endothelial, and immune cells. Despite its potentia…
View article: Immunologic crosstalk in synovium cartilage and bone under inflammatory stress
Immunologic crosstalk in synovium cartilage and bone under inflammatory stress Open
View article: Diffuse idiopathic skeletal hyperostosis: A review of current literature
Diffuse idiopathic skeletal hyperostosis: A review of current literature Open
View article: Knowledge of Neonatal Danger Signs Among Mothers of Neonates in and Around Chennai: A Cross-Sectional Study
Knowledge of Neonatal Danger Signs Among Mothers of Neonates in and Around Chennai: A Cross-Sectional Study Open
View article: Common Bacteria Causing Otitis Media in Patients Attending a Tertiary Care Hospital: A Cross-sectional Study
Common Bacteria Causing Otitis Media in Patients Attending a Tertiary Care Hospital: A Cross-sectional Study Open
Background and Aims: Chronic suppurative otitis media (CSOM), a prevalent middle ear inflammation, presents challenges in the post-coronavirus disease era due to increased patient loads, stringent infection control and irrational antibioti…
View article: Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions Open
The gut microbiome, a complex ecosystem of microorganisms, has a significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which i…
View article: Cross-talks between osteoporosis and gut microbiome
Cross-talks between osteoporosis and gut microbiome Open
The gut microbiome comprises a vast community of microbes inhabiting the human alimentary canal, playing a crucial role in various physiological functions. These microbes generally live in harmony with the host; however, when dysbiosis occ…
View article: Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis
Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis Open
Background: Femoroacetabular impingement (FAI) is a frequently observed hip condition among young, active individuals—especially athletes—that can result in pain, restricted mobility, and a heightened risk of osteoarthritis. Hip arthroscop…
View article: Framework for Adoption of Enabling Technologies for Improved Outcomes in Spine Surgery
Framework for Adoption of Enabling Technologies for Improved Outcomes in Spine Surgery Open
Study Design Narrative Review. Objectives We aim to investigate the integration and impact of enabling technologies, such as augmented reality, virtual reality, mixed reality, navigation, robotics, and artificial intelligence within the do…
View article: Decoding Cytokine Dynamics: Wharton’s Jelly Stromal Cells and Chondro-Differentiates in PHA-Stimulated Co-Culture
Decoding Cytokine Dynamics: Wharton’s Jelly Stromal Cells and Chondro-Differentiates in PHA-Stimulated Co-Culture Open
Introduction: Articular cartilage damage presents a significant clinical challenge, with limited options for effective regeneration. Mesenchymal stromal cells (MSCs) derived from Wharton’s jelly (WJ) are a promising cell source for cartila…
View article: Efficacy of Dialkylcarbamoylchloride (DACC)-Impregnated Dressings in Surgical Wound Management: A Review
Efficacy of Dialkylcarbamoylchloride (DACC)-Impregnated Dressings in Surgical Wound Management: A Review Open
Surgical site infections (SSIs) are a significant challenge in postoperative care, leading to increased morbidity, extended hospital stays, and elevated healthcare costs. Traditional antimicrobial dressings, such as those containing silver…
View article: Relation of Serum Vitamin-D Level with Serum Interleukin-6 and Interleukin-10 in Patients with Primary Osteoarthritis of Knee
Relation of Serum Vitamin-D Level with Serum Interleukin-6 and Interleukin-10 in Patients with Primary Osteoarthritis of Knee Open
Introduction: Osteoarthritis (OA) of the knee is a prevalent degenerative condition influenced by inflammatory processes. Vitamin D possesses immunomodulatory properties that could potentially impact cytokine expression, notably interleuki…
View article: Surgical Management of Snapping Quadriceps Caused by Distal Femur Osteochondroma: A Case Report
Surgical Management of Snapping Quadriceps Caused by Distal Femur Osteochondroma: A Case Report Open
Introduction: Osteochondromas, common benign bone tumors, can lead to complications such as snapping quadriceps when located near joints such as the knee. This case report discusses a rare instance of a distal femur osteochondroma causing …
View article: Primary Synovial Chondromatosis of the Hip Joint: A Case Report
Primary Synovial Chondromatosis of the Hip Joint: A Case Report Open
Introduction: Primary synovial chondromatosis (PSC) is a rare benign disorder characterized by cartilaginous nodule formation within synovial tissue. Hip joint involvement is uncommon, and optimal surgical management remains debated. Case …
View article: Uncommon Presentation of Hip Pain Due to Calcific Tendonitis in the Rectus Femoris
Uncommon Presentation of Hip Pain Due to Calcific Tendonitis in the Rectus Femoris Open
Introduction: Calcific tendonitis is characterized by calcium hydroxyapatite crystal deposition in tendons, leading to inflammation and pain. While predominantly observed in the rotator cuff tendons of the shoulder, its occurrence in the r…
View article: Impact of curcumin on gut microbiome
Impact of curcumin on gut microbiome Open
The intricate interplay between natural compounds like curcumin and the gut microbiome has gained significant attention in recent years due to their potential therapeutic implications in various health conditions. Curcumin, a polyphenolic …
View article: Gut microbiome and orthopaedic health: Bridging the divide between digestion and bone integrity
Gut microbiome and orthopaedic health: Bridging the divide between digestion and bone integrity Open
The gut microbiome, a complex ecosystem of microorganisms in the digestive tract, has emerged as a critical factor in human health, influencing metabolic, immune, and neurological functions. This review explores the connection between the …
View article: Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts
Molecular Mimicry Between Gut Microbiome and Rheumatoid Arthritis: Current Concepts Open
Rheumatoid arthritis (RA) represents an autoimmune condition impacted by a combination of genetic and environmental factors, with the gut microbiome (GMB) being one of the influential environmental factors. Patients with RA display notable…
View article: Clinical Outcomes of Acute Pyelonephritis in Type 2 Diabetes Mellitus
Clinical Outcomes of Acute Pyelonephritis in Type 2 Diabetes Mellitus Open
Background Diabetes mellitus (DM) is a prevalent predisposing factor for urinary tract infections (UTIs). Among hospitalized patients with acute pyelonephritis, UTIs are more common, severe, and associated with worse outcomes, particularly…