Swarnabh Bhattacharya
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View article: Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation
Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation Open
Enterocytes and four secretory cell types derive from stem cells located in intestinal crypts. Whereas secretory goblet and Paneth cells have long been considered distinct, we find high overlap in their transcripts and sites of accessible …
View article: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation Open
View article: miR-184 represses β-catenin and behaves as a skin tumor suppressor
miR-184 represses β-catenin and behaves as a skin tumor suppressor Open
miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation …
View article: Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation Open
Summary Enteroendocrine cells (EECs), which secrete serotonin (enterochromaffin cells, EC) or a dominant peptide hormone, serve vital physiologic functions. As with any adult human lineage, the basis for terminal cell diversity remains obs…
View article: Eyes open on stem cells
Eyes open on stem cells Open
View article: miR-184 represses β-catenin and behaves as a skin tumor suppressor
miR-184 represses β-catenin and behaves as a skin tumor suppressor Open
miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation …
View article: The biophysical property of the limbal niche maintains stemness through YAP
The biophysical property of the limbal niche maintains stemness through YAP Open
View article: Stem cell responses to stretch and strain
Stem cell responses to stretch and strain Open
Recent studies highlight how stem cells perceive and respond to various biomechanical cues from the extracellular niche and neighboring cells. These combined inputs drive certain stem cell behaviors, including cell fate decisions, and may …
View article: Biomechanical property of limbal niche maintains stemness through YAP
Biomechanical property of limbal niche maintains stemness through YAP Open
Stem cells’ (SCs) decision to self-renew or differentiate largely depends on the external control of their niche. However, the complex mechanisms that underlie this crosstalk are poorly understood. To address this question, we focused on t…
View article: Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing Open
View article: Capturing limbal epithelial stem cell population dynamics, signature, and their niche
Capturing limbal epithelial stem cell population dynamics, signature, and their niche Open
Stem cells (SCs) are traditionally viewed as rare, slow-cycling cells that follow deterministic rules dictating their self-renewal or differentiation. It was several decades ago, when limbal epithelial SCs (LSCs) that regenerate the cornea…
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Cover Image Open
View article: SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium
SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium Open
Mutations in key transcription factors SOX2 and P63 were linked with developmental defects and postnatal abnormalities such as corneal opacification, neovascularization, and blindness. The latter phenotypes suggest that SOX2 and P63 may be…
View article: RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells
RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells Open
The transition from naive to primed state of pluripotent stem cells is hallmarked by epithelial-mesenchymal transition, metabolic switch from oxidative phosphorylation to aerobic glycolysis, and changes in the epigenetic landscape. Since t…
View article: microRNA-184 Induces a Commitment Switch to Epidermal Differentiation
microRNA-184 Induces a Commitment Switch to Epidermal Differentiation Open