Swathi V. Iyer
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View article: Challenges and Future Directions in Breast Cancer Segmentation: A Research Perspective
Challenges and Future Directions in Breast Cancer Segmentation: A Research Perspective Open
Breast cancer is one of the most aggressive and widespread illnesses afflicting women across the globe. Fast and precise segmentation techniques are essential for early detection, diagnosis, and treatment planning. This paper reviews compr…
View article: PATH-09. THE SEARCH FOR A NOVEL SUBTYPE OF GLIOBLASTOMA AND ITS CELL-OF-ORIGIN
PATH-09. THE SEARCH FOR A NOVEL SUBTYPE OF GLIOBLASTOMA AND ITS CELL-OF-ORIGIN Open
Glioblastoma (GBM) has been computationally classified into three molecular subtypes (i.e., classical, proneural and mesenchymal). However, these subtypes lack strong biological and clinical implications. Therefore, our group has proposed …
View article: MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma
MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the prognosis of HCC patients, especially those with metastasis, remains extremely poor. This is partly due to unclear molecular mechanisms underlying HCC meta…
View article: Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma
Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma Open
This study warrants a future evaluation of this formulation for gene silencing efficiency of mutant p53 in tissue culture and animal models for the treatment of osteosarcoma.
View article: Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression Open
The ability of cancer cells to survive and grow in anchorage- and serum-independent conditions is well correlated with their aggressiveness. Here, using a human whole-genome shRNA library, we identify TMIGD3 isoform1 (i1) as a factor that …
View article: ROLES OF TMIGD3 AND A3AR IN SUPPRESSION OF OSTEOSARCOMA MALIGNANCY
ROLES OF TMIGD3 AND A3AR IN SUPPRESSION OF OSTEOSARCOMA MALIGNANCY Open
Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Despite advances in the treatment for OS, the survival rate of high-grade OS has reached a plateau and remains at 50-80% for the past three…
View article: Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities
Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities Open
Many p53 hotspot mutants not only lose the transcriptional activity, but also show dominant-negative (DN) and oncogenic gain-of-function (GOF) activities. Increasing evidence indicates that knockdown of mutant p53 (mutp53) in cancer cells …