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View article: PI3Kα inhibitors: structural advances, synthesis strategies, and anticancer potential
PI3Kα inhibitors: structural advances, synthesis strategies, and anticancer potential Open
View article: Raktapradoshaja Vikara and their Upakrama
Raktapradoshaja Vikara and their Upakrama Open
In Ayurveda, Rakta Dhatu (blood tissue) is an important component responsible for nourishing the body and maintaining life. It plays a vital role in nourishment, oxygenation, immunity and overall vitality. Rakta is primarily governed by Pi…
View article: Predicting Cancer Outcomes: A Comparative Study of ML Models
Predicting Cancer Outcomes: A Comparative Study of ML Models Open
Prognostic accuracy in cancer is vital for timely diagnosis and effective treatment planning. This study evaluates the performance of three machine learning techniques—Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and Decision T…
View article: Effect of recombinant human parathyroid hormone and zoledronic acid on osteoblast gene expression using multifaceted approach: An in vitro study
Effect of recombinant human parathyroid hormone and zoledronic acid on osteoblast gene expression using multifaceted approach: An in vitro study Open
BACKGROUND Bone is an endocrine organ that despite being inert in appearance constantly undergoes remodeling, in which wear and tear of bone cells occur. With more than two decades of clinical experience, the molecular mechanisms of anti-f…
View article: Neurotrophin Peptidomimetics: A new era in precision neurology and drug development
Neurotrophin Peptidomimetics: A new era in precision neurology and drug development Open
View article: Type 2 Diabetes Compromises SARS-CoV-2-Specific Immunological Memory Following ChAdOx1 nCoV-19 Vaccination
Type 2 Diabetes Compromises SARS-CoV-2-Specific Immunological Memory Following ChAdOx1 nCoV-19 Vaccination Open
View article: Exploring the Feasibility of a Bracketing Approach Utilizing Modeling for Development of Long-Acting Injectables for Regulatory Approval—A Case Study Using Levonorgestrel
Exploring the Feasibility of a Bracketing Approach Utilizing Modeling for Development of Long-Acting Injectables for Regulatory Approval—A Case Study Using Levonorgestrel Open
Background: The development of long-acting products of a characterized drug substance is of great interest. It is possible to support the development of these products with available clinical data by matching the exposure to a predefined b…
View article: Effect of Ushnodaka in Jwara - A Review
Effect of Ushnodaka in Jwara - A Review Open
In medical practice, Jwara is the most frequently observed clinical condition, occurring either as a primary disease or as a secondary symptom associated with other morbidities. Acharya Charaka has described the disease in which there is r…
View article: Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine by upregulating genes promoting memory T cell responses
Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine by upregulating genes promoting memory T cell responses Open
The ChAdOx1 nCoV-19 (COVISHIELD) vaccine has emerged as a pivotal tool in the global fight against the COVID-19 pandemic. In our previous study eligible subjects were supplemented with calcifediol, a direct precursor to the biologically ac…
View article: Calcifediol boosts the efficacy of ChAdOx1 nCoV-19 (COVISHIELD) vaccine via upregulation of key genes associated with memory T cell responses
Calcifediol boosts the efficacy of ChAdOx1 nCoV-19 (COVISHIELD) vaccine via upregulation of key genes associated with memory T cell responses Open
The ChAdOx1 nCoV-19 (COVISHIELD) vaccine has emerged as a pivotal tool in the global fight against the COVID-19 pandemic. In our previous study eligible subjects were supplemented with calcifediol, a direct precursor to the biologically ac…
View article: Hypoxia Stress-Induced miRNAs: A Comprehensive Enrichment Analysis in High-Altitude Livestock
Hypoxia Stress-Induced miRNAs: A Comprehensive Enrichment Analysis in High-Altitude Livestock Open
MicroRNAs are short (~22 nucleotides) endogenous non-coding RNAs that regulate gene expression post-transcriptionally by binding to the 3’ UTRs of target mRNAs. Many cancer types demonstrate significantly altered miRNA expression profiles,…
View article: Effect of calcifediol supplementation as add-on therapy on the immune repertoire in recipients of the ChAdOx1 nCoV-19 vaccine: A prospective open-label, placebo-controlled, clinical trial
Effect of calcifediol supplementation as add-on therapy on the immune repertoire in recipients of the ChAdOx1 nCoV-19 vaccine: A prospective open-label, placebo-controlled, clinical trial Open
View article: Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches Open
View article: Target Specific Uptake of a Newly Synthesized Radiolabeled 5α-Reductase Inhibitor “Tc-99m-17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-yl Phenoxyacetate (Tc-99m-17a-Aza Steroid)” in Rat Prostatic Neoplastic Lesions
Target Specific Uptake of a Newly Synthesized Radiolabeled 5α-Reductase Inhibitor “Tc-99m-17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-yl Phenoxyacetate (Tc-99m-17a-Aza Steroid)” in Rat Prostatic Neoplastic Lesions Open
Objective: Considering the 5α-reductase (5AR) inhibitory activity of the oximes and the importance of the ester group in increasing the anti-androgenic property, we reasoned to synthesize a compound having a lactam group in ring D and an e…
View article: Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity
Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity Open
Aging is a complex biological process and environmental risk factors like pesticide exposure have been implicated in the increased incidence of age-related neurodegenerative diseases like Parkinson’s disease (PD) but the etiology remains u…
View article: Developing Tailor-Made Microbial Consortium for Effluent Remediation
Developing Tailor-Made Microbial Consortium for Effluent Remediation Open
The work describes a biofilm-based soluble sulphate reduction system, which can treat up to 1600 ppm of soluble sulphate within 3.5 hours of incubation to discharge level under ambient condition using a well-characterized sulphate-reducing…