Swati Choksi
YOU?
Author Swipe
View article: ATF4-mediated expression of NOXA is critical for necroptosis driven by glucose deprivation
ATF4-mediated expression of NOXA is critical for necroptosis driven by glucose deprivation Open
Glucose deprivation (GD), a common metabolic stress condition, has been recognized as a potent inducer of necroptotic cell death. Our previous findings suggested that the mitochondrial protein, Noxa, may be involved in mediating the releas…
View article: Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity
Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity Open
Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is engaged in triggering the rupture of cell plasma membrane. MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface prot…
View article: ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer
ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer Open
Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis plays a major role in tumor necrosis. Although several key necroptosis regulators including receptor interacting protein kinase 1 (RIPK1) have been iden…
View article: Receptor-interacting protein kinase 1 is akey mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3ligand-promoted invasion in cholangiocarcinoma
Receptor-interacting protein kinase 1 is akey mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3ligand-promoted invasion in cholangiocarcinoma Open
Background Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. However, TLR3 signaling can also harbor pro-tumorigenic consequences. Therefore, we examined the…
View article: Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis Open
Cholangiocarcinoma (CCA), a malignant tumor originating in the biliary tract, is well known to be associated with adverse clinical outcomes and high mortality rates due to the lack of effective therapy. Evasion of apoptosis is considered a…
View article: Role of Retinoic Acid Receptor-γ in DNA Damage-Induced Necroptosis
Role of Retinoic Acid Receptor-γ in DNA Damage-Induced Necroptosis Open
DNA-damaging compounds, commonly used as chemotherapeutic drugs, are known to trigger cells to undergo programmed cell death such as apoptosis and necroptosis. However, the molecular mechanism of DNA damage-induced cell death is not fully …
View article: Switching from TNF-induced inflammation to death signaling
Switching from TNF-induced inflammation to death signaling Open
TNFR1-mediated cell signaling involves complex molecular pathways leading to inflammation and death. Cytosolic RARγ plays a pivotal role in converting TNF-induced inflammatory responses to RIP1 initiated cell death and this finely regulate…
View article: Human macrophages survive and adopt activated genotypes in living zebrafish
Human macrophages survive and adopt activated genotypes in living zebrafish Open
The inflammatory response, modulated both by tissue resident macrophages and recruited monocytes from peripheral blood, plays a critical role in human diseases such as cancer and neurodegenerative disorders. Here, we sought a model to inte…
View article: Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling
Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling Open
Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAF…
View article: NADPH Oxidases Are Essential for Macrophage Differentiation
NADPH Oxidases Are Essential for Macrophage Differentiation Open
NADPH oxidases (NOXs) are involved in inflammation, angiogenesis, tumor growth, and osteoclast differentiation. However, the role of NOX1 and NOX2 in macrophage differentiation and tumor progression is still elusive. Here we report that NO…