Swati Choudhary
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View article: Psychiatric manifestations in ulcerative colitis: a North Indian cohort study
Psychiatric manifestations in ulcerative colitis: a North Indian cohort study Open
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that causes results in gastrointestinal and other health issues. Psychiatric problems are being recognized more often but are still often missed, particularly in I…
View article: Comparative analysis of Prevalence of Attention Deficit Hyperactivity Disorder and parental quality of life Amongst Students of Government and Private Schools
Comparative analysis of Prevalence of Attention Deficit Hyperactivity Disorder and parental quality of life Amongst Students of Government and Private Schools Open
Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that affects children worldwide. This study focuses on understanding the prevalence of ADHD in elementary school classrooms in India and ex…
View article: Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors
Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors Open
View article: Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate
Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate Open
Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin sulfate (ofCS)…
View article: Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors
Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors Open
Glycosaminoglycans are often deprioritized as targets for synthetic immunotherapy due to the complexity of glyco-epitopes and limited options for obtaining specific subtype-binding. Solid tumors express proteoglycans that are modified with…
View article: Premenstrual Dysphoric Disorder and Its Relationship with Stress: A Study on Medical and Allied Medical Science Students at a Tertiary Care Center
Premenstrual Dysphoric Disorder and Its Relationship with Stress: A Study on Medical and Allied Medical Science Students at a Tertiary Care Center Open
Background: Premenstrual dysphoric disorder (PMDD), now classified under mood disorders, is characterized by a group of cognitive, affective, and physical symptoms and is associated with socio-occupational dysfunction with poor quality of …
View article: Antifungal Activity of Cassia fistula L. Extracts against Macrophomina phaseolina (TASSI.) Goid.: In vitro Study
Antifungal Activity of Cassia fistula L. Extracts against Macrophomina phaseolina (TASSI.) Goid.: In vitro Study Open
Aim: To evaluate the anti-fungal properties of Cassia fistula with alcohol soluble and aqueous extracts against Macrophomina phaseolina.
Methods: Ethanolic, methanolic and aqueous extracts were prepared and qualitative and quantitative an…
View article: Recurrent catatonia in a patient with Schizophrenia and autism spectrum disorder
Recurrent catatonia in a patient with Schizophrenia and autism spectrum disorder Open
Catatonia occurs in more than 10% of acute psychiatric illnesses.[1] Catatonia is considered a syndrome associated with numerous conditions. A systematic review reported that 20.2% of autism spectrum disorder (ASD) individuals had features…
View article: Comparison of thoracic segmental spinal anaesthesia and lumbar spinal anaesthesia for percutaneous nephrolithotomy
Comparison of thoracic segmental spinal anaesthesia and lumbar spinal anaesthesia for percutaneous nephrolithotomy Open
Background: This study aimed to compare the feasibility and safety of low thoracic segmental spinal anesthesia (TSSA) and conventional lumbar spinal anesthesia (LSA) in percutaneous nephrolithotomy (PCNL). Methods: Sixty adult patients und…
View article: Cannabis use and its relationship with bipolar disorder: A systematic review and meta-analysis
Cannabis use and its relationship with bipolar disorder: A systematic review and meta-analysis Open
Cannabis use has been stated as a causal risk factor for the occurrence of schizophrenia and other psychotic disorders. There is a dearth of literature stating the association of cannabis with bipolar disorder. This review aimed to find th…
View article: Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice Open
Background The malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian cancer cells. Previously, we produced a bispecific construct targeting ofCS and human T cell…
View article: Additional file 1 of Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
Additional file 1 of Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice Open
Additional file 1: Sup. Fig. 1. (A) ELISA showing binding of V-aCD3Mu (Coupled)(Kd = 38.8, Bmax = 3.31), rVAR2 (Kd and Bmax not determined), and V-aCD3Mu (Fused)(Kd = 14.2, Bmax = 3.36) to CSPG on a decorin backbone. Data is representative…
View article: Pathways of care and attitudes toward psychotropics in patients with depressive disorders and psychotic disorders
Pathways of care and attitudes toward psychotropics in patients with depressive disorders and psychotic disorders Open
Objectives: Delay in institution of appropriate mental healthcare is closely linked with attitudes, stigma, and availability of services, which further directs the help seeking pathways. This study was aimed to assess the pathway of care a…
View article: Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA Open
Malaria during pregnancy is a major global health problem caused by infection with Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected erythrocytes in the placenta. Here, erythrocytes infected by late bl…
View article: Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer
Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer Open
Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. Here we show that changes in chondroitin sulfate (CS), a major glyc…
View article: Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner
Author Correction: The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner Open
This Article contained an error in the consent of some of the patients used in Figure 4. Following an institute-led investigation within BARTS Cancer Institute post-publication, no documentation of informed consent from the nine lung cance…
View article: Analysis of stress, coping strategies and happiness of urban and rural students during COVID-19 pandemic
Analysis of stress, coping strategies and happiness of urban and rural students during COVID-19 pandemic Open
The present study aimed to analyze the Stress, Coping Strategies and Happiness of Urban and Rural Students During Covid-19 Pandemic. A sample of one hundred thirty postgraduate students was the subject for the study. Subjects were randomly…
View article: Oral Health Status in Mentally Disabled Children, Dental Care Knowledge of Parents, and the Impact of Audiovisual Oral Health Education Program
Oral Health Status in Mentally Disabled Children, Dental Care Knowledge of Parents, and the Impact of Audiovisual Oral Health Education Program Open
Shah RK, Choudhary S, Tandon S. Oral Health Status in Mentally Disabled Children, Dental Care Knowledge of Parents, and the Impact of Audiovisual Oral Health Education Program. Int J Clin Pediatr Dent 2022;15(2):143-148.
View article: Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells
Internalization and trafficking of CSPG-bound recombinant VAR2CSA lectins in cancer cells Open
Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how …
View article: Journey of JIACAM: Vision, Challenges and Opportunities
Journey of JIACAM: Vision, Challenges and Opportunities Open
View article: Patient perception towards males in nursing profession in India: A single center, cross-sectional survey
Patient perception towards males in nursing profession in India: A single center, cross-sectional survey Open
Background and aim: One of the major changes that have occurred in the nursing profession today is the increasing need for men in nursing, which was felt more during recent pandemic. Further, it would be beneficial to have a positive view …
View article: Detection of VAR2CSA-Captured Colorectal Cancer Cells from Blood Samples by Real-Time Reverse Transcription PCR
Detection of VAR2CSA-Captured Colorectal Cancer Cells from Blood Samples by Real-Time Reverse Transcription PCR Open
Analysis of circulating tumor cells (CTCs) from blood samples provides a non-invasive approach for early cancer detection. However, the rarity of CTCs makes it challenging to establish assays with the required sensitivity and specificity. …
View article: The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility Open
View article: Relapse in bipolar disorder in hospitalized patients with COVID-19
Relapse in bipolar disorder in hospitalized patients with COVID-19 Open
COVID-19 has adversely affected the lives of people with bipolar disorder (BD). We have reported three patients with BD, who suffered from relapse after being diagnosed with COVID-19. Patient X is a 54-year-old man who developed manic epis…
View article: Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer
Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer Open
Broad-spectrum therapeutics in non-small cell lung cancer (NSCLC) are in demand. Most human solid tumors express proteoglycans modified with distinct oncofetal chondroitin sulfate (CS) chains that can be detected and targeted with recombin…
View article: Internalization and Trafficking of CSPG-Bound Recombinant VAR2CSA Lectins in Cancer Cells
Internalization and Trafficking of CSPG-Bound Recombinant VAR2CSA Lectins in Cancer Cells Open
Proteoglycans are proteins that are modified with glycosaminoglycan chains. Chondroitin sulfate proteoglycans (CSPGs) are currently being exploited as targets for drug-delivery in various cancer indications, however basic knowledge on how …
View article: Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding Open
Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the…
View article: Development of a bispecific immune engager using a recombinant malaria protein
Development of a bispecific immune engager using a recombinant malaria protein Open
View article: Promotion of Wellness and Prevention of Illness among Medical Students
Promotion of Wellness and Prevention of Illness among Medical Students Open
Wellness is a concept of optimal well-being, an essential component for medical students at the personal and professional level. While medical education and healthcare service demand an efficient coping reservoir and resilience, but greate…
View article: Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity Open