Swetha Ananth
YOU?
Author Swipe
View article: Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation Open
View article: Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells
Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells Open
Resting CD4 T cells resist productive HIV-1 infection. The HIV-2/simian immunodeficiency virus protein viral accessory protein X (Vpx) renders these cells permissive to infection, presumably by alleviating blocks at cytoplasmic reverse tra…
View article: A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation Open
The host transmembrane protein SERINC5 is incorporated into retrovirus particles and inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it from the cell surface and preventing its incorporation int…
View article: HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function
HIV‐1 infection of CD4 T cells impairs antigen‐specific B cell function Open
View article: Multifunctional Roles of the N-Terminal Region of HIV-1 <sub>SF2</sub> Nef Are Mediated by Three Independent Protein Interaction Sites
Multifunctional Roles of the N-Terminal Region of HIV-1 <sub>SF2</sub> Nef Are Mediated by Three Independent Protein Interaction Sites Open
HIV-1 Nef critically determines virus spread and disease progression in infected individuals by acting as a protein interaction adaptor via incompletely defined mechanisms and ligands. Residues 12 to 39 near the N terminus of Nef have been…
View article: SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue Open
SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance of SERINC5 antagonism for viral replication and cytopathi…