Explanipedia

Chorea in GRID2 -Related Disorder: Expanding the Phenotypic Spectrum Beyond Cerebellar Ataxia and Tonic Upgaze Open

G. Bharanidharan, Asish Vijayaraghavan, Syam Krishnan, Divya KP, Soumya Sundaram · 2025

Integrative lipidomics of brain and plasma uncovers sex-specific metabolic signatures in Parkinson’s disease Open

Udit Agrawal, Priya Nataraj, Aakash Chandramouli, Syam Krishnan, Siddhesh S. Kamat , et al. · 2025

Lipid dysregulation is increasingly recognized as a key feature of Parkinson’s disease (PD). A central unresolved question, however, is whether lipidomic signatures identified in accessible peripheral biofluids faithfully recapitulate the …

Advancements in Immunomodulatory Therapies for IBD and Their Interplay With the Gut–Brain Axis: An Updated Review of Current Literature and Beyond Open

Mayank Jha, Aiman Waheed, Jubran Al Balushi, Syam Krishnan, Ali Najam , et al. · 2025

Background and Aims The incidence of inflammatory bowel disease (IBD), characterized by chronic gastrointestinal inflammation, has significantly increased over the last two decades. Concurrently, advancements in treatment strategies have a…

Demographic and Clinical Profiles of Parkinson's Disease in India: Observations from a Nation‐Wide Multicenter Study Open

Asha Kishore, Rupam Borgohain, Divya Kalikavil Puthenveedu, Roopa Rajan, Pramod Kumar Pal , et al. · 2025

Background Parkinson's disease (PD) phenotype may vary with genetic, ethno‐geographic, cultural, and environmental factors. Objectives The aim was to develop a clinical database of PD in India and assess the influence of age‐at‐onset (AAO)…

Hereditary Spastic Paraplegia Type 7 With Early-Onset Parkinsonism Responsive to Subthalamic Deep Brain Stimulation Open

Sayooja Sachithanandan, Krishnakumar Pisharody, Asish Vijayaraghavan, Lokesh Vellore Dasarathan, Divya Kalikavil Puthenveedu , et al. · 2025

Pharmacotherapy in Early Parkinson’s Disease: A Pragmatic Approach Open

Sayooja Sachithanandan, Asish Vijayaraghavan, Reshma Venugopal, Divya Kalikavil Puthenveedu, Syam Krishnan · 2025

Phenotypic Variability in ATP13A2 Mutations: The First Report of SPG78 From India Open

Lakshmi Priya L, Asish Vijayaraghavan, Syam Krishnan · 2025

Deep Learning–Based Artificial Intelligence Algorithm to Classify Tremors from Hand‐Drawn Spirals Open

Reghu Anandapadmanabhan, Aayushi Vishnoi, Geetha Raman, Jeena Thachan, Beulah Amulyavathi Gangaraju , et al. · 2025

Background No objective biomarkers exist for diagnosing and classifying tremor syndromes. Objective The aim was to develop and validate a deep learning (DL) algorithm for classifying tremors from hand‐drawn pen‐on‐paper spirals. Methods We…

Catch Me If You Can! – The “Whack-a-Mole” Sign for Functional Tremor Open

Sayooja Sachithanandan, Asish Vijayaraghavan, Kiren George Koshy, Divya Kalikavil Puthanveedu, Syam Krishnan · 2025

Deciphering the Genetic Architecture of Parkinson’s Disease in India Open

Asha Kishore, Ashwin Ashok Kumar Sreelatha, Amabel Tenghe, Rupam Borgohain, Divya Kalikavil Puthanveedu , et al. · 2025

The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability in PD has been studied predominantly in European populati…

Characterizing Parkinson’s Disease-Associated Pain in Native Patients with Malayalam Version of the King’s Parkinson’s Disease Pain Scale Open

Prabhu Selvaraj, Asish Vijayaraghavan, Vineeth Radhakrishnan, Divya Kalikavil Puthenveedu, Gangadhara Sarma , et al. · 2025

Background and Objectives: Pain is an important non-motor symptom in Parkinson’s disease (PD) and is often under-recognized. Pain is also a symptom frequently reported by non-PD elderly subjects. The King’s Parkinson’s Disease Pain Scale (…

Progressive Supranuclear Palsy in India: Past, Present, and Future Open

Srinivas Raju, Kuldeep Shetty, Lulup Kumar Sahoo, Vijayashankar Paramanandam, Jay M. Iyer , et al. · 2024

Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the e…

Resequencing the complete SNCA locus in Indian patients with Parkinson’s disease Open

Asha Kishore, Marc Sturm, Kanchana Soman Pillai, Christopher Hakkaart, Divya Kalikavil Puthanveedu , et al. · 2024

The genetic loci implicated in familial Parkinson’s disease (PD) have limited generalizability to the Indian PD population. We tested mutations and the frequency of known mutations in the SNCA gene in a PD cohort from India. We selected 29…

Clinical and Epidemiological Profile of Parkinson's Disease in India Open

Asha Kishore, Rupam Borgohain, Divya Kalikavil Puthenveedu, Roopa Rajan, Pramod Kumar Pal , et al. · 2024

Issue Information Open

Kailash Bhatia, Marcelo Merello, Günther Deuschl, Stanley Fahn, Mark Hallett , et al. · 2023

Movement Disorders Clinical Practice-is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/…

Deep Brain Stimulation for Parkinson's Disease‐the Developing World's Perspective Open

Khushboo Patel, Divya Kalikavil Puthanveedu, Asish Vijayaraghavan, Krishnakumar Kesavapisharady, Gangadhara Sarma , et al. · 2023

Background Deep brain stimulation (DBS) is the most widely used device‐assisted therapy in patients with moderately advanced stages of Parkinson's disease (PD) experiencing motor complications. Only a minority of eligible patients get the …

ROLE OF CEREBELLUM BASAL GANGLIA DIRECT SUBCORTICAL NETWORK IN THE PATHOPHYSIOLOGY OF PARKINSON’S DISEASE Open

Vineeth Radhakrishnan, Syam Krishnan, Cécile Galléa, Chadrasekharan Kesavadas, Bejoy Thomas , et al. · 2023

META-ANALYSIS OF THE PARKINSON’S DISEASE ASSOCIATED ALTERATIONS IN GUT MICROBIOME AND METABOLOME PROFILE IDENTIFIES DISEASE-SPECIFIC BIOMARKERS FOR DIAGNOSTIC APPLICATION Open

P A Aneesa, Dania Jose, Syam Krishnan, P. S. Baby Chakrapani · 2023

PINK‐1 Parkinson's Disease Presenting with Dystonic Head Tremor Open

Asish Vijayaraghavan, Patel Khushboo Subhash, Prabhu Selvaraj, Divya Kalikavil Puthanveedu, Syam Krishnan · 2023

Subthalamic Deep Brain Stimulation for Parkinson’s Disease—An Unexpected Encounter in the Lead Trajectory Open

Asish Vijayaraghavan, Sam Scaria, Vineeth Radhakrishnan, Divya Kalikavil Puthenveedu, Syam Krishnan , et al. · 2023

Dear Sir, Deep brain stimulation (DBS) is currently the standard of care for patients with Parkinson's disease (PD) experiencing motor complications.[1] The subthalamic nucleus (STN) is the most widely used target for DBS in PD.[2] We pres…

Hemichorea after internal carotid artery bifurcation aneurysm clipping Open

Suraj Gopal, Easwer Hv, Jayanand Sudhir, Prakash Nair, Syam Krishnan · 2023

Involuntary movements following aneurysm surgery are rare. Here, we report the case of a patient who developed left hemichorea following surgical clipping of a right internal carotid artery bifurcation aneurysm. The movement disorder resul…

Movement Disorders in GRIA2‐Related Disorder – Expanding the Genetic Spectrum of Developmental Dyskinetic Encephalopathy Open

Asish Vijayaraghavan, Madhusoodanan Urulangodi, Karthika Ajit Valaparambil, Soumya Sundaram, Syam Krishnan · 2023

Cerebellar and basal ganglia structural connections in humans: Effect of aging and relation with memory and learning Open

Vineeth Radhakrishnan, Cécile Galléa, Romain Valabrègue, Syam Krishnan, Chandrasekharan Kesavadas , et al. · 2023

Introduction The cerebellum and basal ganglia were initially considered anatomically distinct regions, each connected via thalamic relays which project to the same cerebral cortical targets, such as the motor cortex. In the last two decade…

Huffing and puffing sign in functional axial jerks with secondary gait impairment Open

Khushboo Patel, Asish Vijayaraghavan, Syam Krishnan, Divya Kalikavil Puthenveedu · 2023

Propriospinal myoclonus (PSM) is characterized by predominant axial jerk-like movements. To date, most of the PSM cases reported in the literature are considered to be functional (psychogenic) in origin. The “huffing and puffing sign” is a…

Hemifacial spasm resulting from vertebrobasilar dolichoectasia in three siblings: A case report Open

Khushboo Patel, Asish Vijayaraghavan, Syam Krishnan, Divya K. Puthenveedu, Ajith Cherian · 2022

Hemifacial spasm is a common peripheral movement disorder that usually results from neurovascular conflict involving the facial nerve motor root exit zone. Although it is a sporadic disease, some cases of familial clustering have been repo…

Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia Open

Asha Kishore, Praveen James, Parvathy Rajeswari, Gangadhara Sarma, Syam Krishnan , et al. · 2022

Botulinum neurotoxin for the treatment of movement disorders Open

Ajith Cherian, Asish Vijayaraghavan, Divya K.P., Syam Krishnan · 2022

Botulinum neurotoxin (BoNT), produced by spore-forming anaerobic bacteria, is the most potent biological toxin and is a powerful therapeutic tool for several clinical indications in neurology and beyond. BoNT inhibits the release of acetyl…

Oromandibular Dystonia – A Systematic Review Open

Udit Saraf, Mitesh Chandarana, KP Divya, Syam Krishnan · 2021

Oromandibular dystonia (OMD) is a clinical problem which is commonly encountered in the practice of movement disorders. OMD results from a variety of genetic and acquired etiologies and can occur as an isolated manifestation, or as part of…

Huntington’s disease presenting as adult-onset tourettism Open

Mitesh Chandarana, Udit Saraf, K. P. Divya, Syam Krishnan · 2021

Huntington’s disease (HD) is an autosomal dominant progressive neurodegenerative disease, caused by trinucleotide repeat expansion (CAG) in the Huntingtin gene ( HTT ) on chromosome 4. It is typically characterized by the combination of ch…

Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods” Open

Mitesh Chandarana, Ajith Cherian, K. P. Divya, Syam Krishnan, Mary Glenda , et al. · 2021

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