Syed Osman Ahmed
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View article: Author Correction: Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series
Author Correction: Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series Open
View article: Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series
Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series Open
View article: POLYRADICULOPATHY FOLLOWING CAR T-CELL THERAPY FOR LYMPHOID MALIGNANCIES, DIAGNOSTIC CHALLENGES: A REPORT OF 3 CASES
POLYRADICULOPATHY FOLLOWING CAR T-CELL THERAPY FOR LYMPHOID MALIGNANCIES, DIAGNOSTIC CHALLENGES: A REPORT OF 3 CASES Open
Objective: Neurotoxicity is a serious but incompletely understood complication of CAR T-cell therapy. here we highlight presentation and diagnostic challenges of non-CNS CAR T-cell therapy complication. Case series: Case 1: A 43-year-old f…
View article: LYSOZYME-INDUCED NEPHROPATHY IN CMML: A RARE BUT SIGNIFICANT COMPLICATION REQUIRING EARLY RECOGNITION AND INTERVENTION
LYSOZYME-INDUCED NEPHROPATHY IN CMML: A RARE BUT SIGNIFICANT COMPLICATION REQUIRING EARLY RECOGNITION AND INTERVENTION Open
Background: CMML is a clonal hematopoietic disorder with features of myelodysplasia and myeloproliferation, characterized by monocytosis. Monocytes secrete lysozyme, a cationic protein filtered by the glomerulus and reabsorbed in proximal …
View article: Correction: Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation
Correction: Non-cryopreserved autologous peripheral blood stem cell transplantation for multiple myeloma and lymphoma in countries with limited resources: practice considerations from the Worldwide Network for Blood and Marrow Transplantation Open
View article: Evaluating the Current Practice in The Preventing of Venous Thromboembolism in Hospitalised Patients with Cancer in Najaf Province, Iraq
Evaluating the Current Practice in The Preventing of Venous Thromboembolism in Hospitalised Patients with Cancer in Najaf Province, Iraq Open
Introduction. Cancer is linked to a hypercoagulable state, resulting in a four-fold increase in the risk of thrombosis, along with an elevated risk of bleeding. Patients with cancer who receive chemotherapy, thromboembolism is considered t…
View article: Genetic and Clinical Progression of MYSM1 Related Bone Marrow Failure into Myeloid Malignancies: Case Series and Review of Literature
Genetic and Clinical Progression of MYSM1 Related Bone Marrow Failure into Myeloid Malignancies: Case Series and Review of Literature Open
MYSM1, located on chromosome 1p32.1, encodes histone H2A deubiquitinase, a transcription regulator involved in DNA damage response. Biallelic MYSM1 variants are linked to rare bone marrow failure syndromes, presenting with cytopenia, B-cel…
View article: Biallelic OSM deficiency presents with juvenile myelodysplastic syndrome and response to treatment
Biallelic OSM deficiency presents with juvenile myelodysplastic syndrome and response to treatment Open
View article: Primary Pulmonary Hypoplasia With Congenital Alveolar Dysplasia Associated With <i>TBX4</i> Gene Deletion: A Case With Autopsy and Molecular Findings
Primary Pulmonary Hypoplasia With Congenital Alveolar Dysplasia Associated With <i>TBX4</i> Gene Deletion: A Case With Autopsy and Molecular Findings Open
Acute respiratory distress in a neonate is a potentially critical condition with multiple possible causes. Developmental etiologies are particularly problematic by virtue of being refractory to routine modalities for enhancing ventilation …
View article: Pediatric-inspired (R3) vs. Adult salvage (FA) chemotherapy in relapsed adolescents and young adults (AYA) acute lymphoblastic leukemia (ALL): A comparative outcome analysis
Pediatric-inspired (R3) vs. Adult salvage (FA) chemotherapy in relapsed adolescents and young adults (AYA) acute lymphoblastic leukemia (ALL): A comparative outcome analysis Open
The pediatric-inspired R3 and adult-based FA regimens yielded similar survival and remission rates in relapsed AYA-ALL. Distinct toxicity profiles suggest that treatment selection should be individualized. Larger, prospective studies are w…
View article: Large Scale In-House Point-of-Care Manufacturing of Clinical Grade Autologous Anti-CD19 CAR T Cells in Saudi Arabia
Large Scale In-House Point-of-Care Manufacturing of Clinical Grade Autologous Anti-CD19 CAR T Cells in Saudi Arabia Open
Chimeric Antigen Receptor T (CAR T) cell therapy targeting the CD19 antigen represents a significant advancement in the treatment of various subtypes of CD19-expressing hematologic malignancies. Nevertheless, the current commercial CAR T m…
View article: Unraveling the Rare Entity of <i>KIT</i> D816V-Negative Systemic Mastocytosis
Unraveling the Rare Entity of <i>KIT</i> D816V-Negative Systemic Mastocytosis Open
Systemic mastocytosis (SM) is a rare type of myeloproliferative neoplasm characterized by abnormal proliferation and infiltration of different tissue by clonal mast cells. The uncontrolled proliferation and activation of mast cells trigger…
View article: Outcomes and Long-Term Survival of Adolescent and Young Adult Patients Admitted to the Intensive Care Unit Following Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Experience of 152 Patients
Outcomes and Long-Term Survival of Adolescent and Young Adult Patients Admitted to the Intensive Care Unit Following Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Experience of 152 Patients Open
Background and objectives: Prognostic factors reliably predicting outcomes for critically ill adolescent and young adult (AYA) patients undergoing allogeneic hematopoietic cell transplantation (allo-HSCT) are lacking. We assessed transplan…
View article: OUTCOME OF APLASTIC ANEMIA ACCORDING TO DISEASE SEVERITY
OUTCOME OF APLASTIC ANEMIA ACCORDING TO DISEASE SEVERITY Open
Objective Background: Aplastic anemia is pancytopenia with a hypocellular bone marrow [<25 % (or 25 to 50 % if <30 % of residual cells are hematopoietic)] due to failure of the bone marrow in the absence of marrow fibrosis or abnormal infi…
View article: P1420: COMPARATIVE STUDY OF CYCLOSPORINE VERSUS TACROLIMUS IN ADDITION TO METHOTREXATE AS GRAFT VERSUS HOST DISEASE PROPHYLAXIS IN MATCHED SIBLING ALLOGENEIC STEM CELL TRANSPLANTATION OF SICKLE CELL DISEASE
P1420: COMPARATIVE STUDY OF CYCLOSPORINE VERSUS TACROLIMUS IN ADDITION TO METHOTREXATE AS GRAFT VERSUS HOST DISEASE PROPHYLAXIS IN MATCHED SIBLING ALLOGENEIC STEM CELL TRANSPLANTATION OF SICKLE CELL DISEASE Open
Topic: 26. Sickle cell disease Background: Allogeneic stem cell transplantation (SCT) with HLA-identical sibling donor is the curative option for sickle cell disease (SCD) with excellent survival outcomes. Cyclosporine (CsA) or Tacrolimus …
View article: The role of androgen therapy in acquired aplastic anemia and other bone marrow failure syndromes
The role of androgen therapy in acquired aplastic anemia and other bone marrow failure syndromes Open
Bone marrow failure syndromes are a heterogeneous group of diseases. With the major advancements in diagnostic tools and sequencing techniques, these diseases may be better classified and therapies may be further tailored. Androgens, a his…
View article: Improved Survival of Adolescents and Young Adults Patients with T-Cell Acute Lymphoblastic Leukemia
Improved Survival of Adolescents and Young Adults Patients with T-Cell Acute Lymphoblastic Leukemia Open
Our single-center experience real-world data in treating T-ALL/LBL-AYA patients with pediatric-inspired protocol demonstrates encouraging results of high survival rate and excellent tolerability for patients aged 18-55 years.
View article: Co-occurrence of Multiple Sclerosis and Severe Aplastic Anemia: A Report of Two Cases Successfully Treated with Allogeneic Hematopoietic Stem Cell Transplantation
Co-occurrence of Multiple Sclerosis and Severe Aplastic Anemia: A Report of Two Cases Successfully Treated with Allogeneic Hematopoietic Stem Cell Transplantation Open
View article: Correction to: Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP of EBMT)
Correction to: Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP of EBMT) Open
View article: Strategic priorities for hematopoietic stem cell transplantation in the EMRO region
Strategic priorities for hematopoietic stem cell transplantation in the EMRO region Open
The World Health Organization-designated Eastern Mediterranean region (EMRO) consists of 22 countries in North Africa and Western Asia with a collective population of over 679 million. The area comprises some of the wealthiest countries pe…
View article: Outcomes of autologous stem cell transplantation for multiple myeloma in Saudi Arabia
Outcomes of autologous stem cell transplantation for multiple myeloma in Saudi Arabia Open
BACKGROUND: In 2015, multiple myeloma (MM) represented 1% of all cancers and about 5% of hematologic malignancies in Saudi cancer registry. We conducted this large study because only small pilot studies have examined MM outcomes after auto…
View article: Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean blood and marrow transplantation (EMBMT) group and severe aplastic anemia working party of the European Society for blood and marrow transplantation (SAAWP of EBMT)
Special issues related to the diagnosis and management of acquired aplastic anemia in countries with restricted resources, a report on behalf of the Eastern Mediterranean blood and marrow transplantation (EMBMT) group and severe aplastic anemia working party of the European Society for blood and marrow transplantation (SAAWP of EBMT) Open
View article: Clinical course and outcomes of COVID‐19 in hematopoietic cell transplant patients, a regional report from the Middle East
Clinical course and outcomes of COVID‐19 in hematopoietic cell transplant patients, a regional report from the Middle East Open
View article: The outcomes of secondary AML post allogeneic hematopoietic cell transplantation significantly depend on the presence of poor‐risk cytogenetic abnormalities
The outcomes of secondary AML post allogeneic hematopoietic cell transplantation significantly depend on the presence of poor‐risk cytogenetic abnormalities Open
Secondary acute myeloid leukemia (sAML) includes AML as a complication of an antecedent hematological disorder or a therapy‐related AML. Large registry‐based data identified sAML as an independent poor‐outcome type of AML post allogeneic h…
View article: Role of gene therapy in Fanconi anemia
Role of gene therapy in Fanconi anemia Open
Gene therapy (GT) has been reported to improve bone marrow function in individuals with Fanconi anemia (FA); however, its clinical application is still in the initial stages. We conducted this systematic review, following the Preferred Rep…
View article: Comprehensive multi-omics analysis of G6PC3 deficiency-related congenital neutropenia with inflammatory bowel disease
Comprehensive multi-omics analysis of G6PC3 deficiency-related congenital neutropenia with inflammatory bowel disease Open
View article: Clinical Course and Outcomes of COVID‐19 in Hematopoietic Cell Transplant Patients: A Regional Report from the Middle East
Clinical Course and Outcomes of COVID‐19 in Hematopoietic Cell Transplant Patients: A Regional Report from the Middle East Open
View article: Improved survival in adolescents and young adults (AYA) patients aged 14–55 years with acute lymphoblastic leukemia using pediatric-inspired protocol – a retrospective analysis of a real-world experience in 79 of patients treated at a national tertiary care referral center
Improved survival in adolescents and young adults (AYA) patients aged 14–55 years with acute lymphoblastic leukemia using pediatric-inspired protocol – a retrospective analysis of a real-world experience in 79 of patients treated at a national tertiary care referral center Open
Our single-center experience real-world data in treating AYA-ALL patients with pediatric-inspired protocol demonstrates encouraging results of high survival rate and excellent tolerability for patients aged 18-55 years.
View article: Unique aspects of Graft-versus-host-disease management in the Eastern Mediterranean region: Report from the Eastern Mediterranean blood and marrow transplantation group: Special report
Unique aspects of Graft-versus-host-disease management in the Eastern Mediterranean region: Report from the Eastern Mediterranean blood and marrow transplantation group: Special report Open
View article: Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT)
Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT) Open