Syed Tasleem Raza
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View article: Influence of Diabetes Mellitus on Metabolic and Hormonal Interactions Promoting Aggressive Prostate Cancer
Influence of Diabetes Mellitus on Metabolic and Hormonal Interactions Promoting Aggressive Prostate Cancer Open
View article: Pharmacokinetics and lipid-lowering efficacy affected by polymorphisms in genetic variability in statin therapy
Pharmacokinetics and lipid-lowering efficacy affected by polymorphisms in genetic variability in statin therapy Open
HMG-CoA reductase inhibitors, commonly known as statins, are among the most widely prescribed and extensively studied drugs used in managing cardiovascular conditions by regulating lipid levels in the blood. Despite their broad use, there …
View article: From biogenesis to biomarkers: the role of piRNAs and PIWI proteins in cervical cancer and beyond
From biogenesis to biomarkers: the role of piRNAs and PIWI proteins in cervical cancer and beyond Open
Cervical cancer remains one of the most prevalent gynecological malignancies worldwide, primarily caused by persistent infection with human papillomavirus. Despite advances in screening and vaccination, cervical cancer continues to be the …
View article: Serum Insulin, Insulin-Like Growth Factor-1, Testosterone and Lipid Profile Levels in Benign Prostatic Hyperplasia and Prostate Cancer at Diagnosis
Serum Insulin, Insulin-Like Growth Factor-1, Testosterone and Lipid Profile Levels in Benign Prostatic Hyperplasia and Prostate Cancer at Diagnosis Open
This study confirms the association of insulin and IGF-1 with BPH and prostate cancer Gleason score and grade.
View article: Synergistic Anticancer Efficacy of Curcumin and Doxorubicin Combination Treatment Inducing S-phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells: An In Vitro Study
Synergistic Anticancer Efficacy of Curcumin and Doxorubicin Combination Treatment Inducing S-phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells: An In Vitro Study Open
View article: Navigating the complexities of hypertension: guidelines, screening and treatment approaches
Navigating the complexities of hypertension: guidelines, screening and treatment approaches Open
Hypertension or high blood pressure, is a prevalent condition and a leading cause of cardiovascular morbidity and mortality worldwide. This review provides an in-depth analysis of the current epidemiology, diagnosis and management of hyper…
View article: Evaluation of cardiopulmonary function and health outcomes among petrol pump attendants in Lucknow district
Evaluation of cardiopulmonary function and health outcomes among petrol pump attendants in Lucknow district Open
Background: Petrol pump attendants face heightened health risks due to prolonged exposure to gasoline fumes, which contain harmful chemicals like benzene and particulate matter. This community is generally neglected regarding their health.…
View article: Prognostic significance of miR 499 expression and Helicobacter pylori infection in malignant lesions of gallbladder cancer: a clinicopathological study
Prognostic significance of miR 499 expression and Helicobacter pylori infection in malignant lesions of gallbladder cancer: a clinicopathological study Open
Background Gallbladder cancer (GBC) is an infrequent type of malignant neoplasm worldwide. There are a number of risk factors that increase a person's likelihood of developing GBC. Gallbladder inflammatory (GID) diseases including cholelit…
View article: Association of ET1 and APE1 Genes Polymorphism with Coronary Artery Disease
Association of ET1 and APE1 Genes Polymorphism with Coronary Artery Disease Open
Coronary artery disease (CAD) is one of the most common cardiovascular diseases (CVDs), being the foremost reason for mortality and disability globally. It is a cascade of polygenic architecture of various disorders as a resultant of compl…
View article: The combination of Curcumin and Doxorubicin on targeting PI3K/AKT/mTOR signaling pathway: an in vitro and molecular docking study for inhibiting the survival of MDA-MB-231
The combination of Curcumin and Doxorubicin on targeting PI3K/AKT/mTOR signaling pathway: an in vitro and molecular docking study for inhibiting the survival of MDA-MB-231 Open
View article: D-56 | Clinical Outcomes Following Interventions by Different Modalities of Percutaneous Coronary Intervention (PCI): An Updated Systematic Review and Network Meta-Analysis
D-56 | Clinical Outcomes Following Interventions by Different Modalities of Percutaneous Coronary Intervention (PCI): An Updated Systematic Review and Network Meta-Analysis Open
View article: Sanger Sequencing of Exon 14 of RB1 Gene Among North Indian Children with Retinoblastoma
Sanger Sequencing of Exon 14 of RB1 Gene Among North Indian Children with Retinoblastoma Open
Introduction: The RB1 gene has been studied for decades. A large number of genetic analytical studies on this gene are published in the Western world, but very few studies from India are available online. RB1 is the most critical gene invo…
View article: cxsAssociation study between single nucleotide polymorphism in thrombospondins THBS1 gene and THBS2 gene and coronary artery disease in Indian population
cxsAssociation study between single nucleotide polymorphism in thrombospondins THBS1 gene and THBS2 gene and coronary artery disease in Indian population Open
Background Coronary artery disease (CAD) is a complex medical condition characterized by atherosclerotic plaque accumulation in coronary arteries, leading to narrowed blood vessels and impaired blood flow. Endothelial dysfunction, smooth m…
View article: Evaluation of the Association between Genetic Polymorphism of Interleukin-1 Beta (–511C/T and +3953C/T) and Cervical Cancer Susceptibility
Evaluation of the Association between Genetic Polymorphism of Interleukin-1 Beta (–511C/T and +3953C/T) and Cervical Cancer Susceptibility Open
Cervical cancer (CC) is the leading cause of cancer-related mortality among women, primarily caused by persistent human papillomavirus (HPV) infection, especially in developing countries. A proinflammatory cytokine, emerging as a major fac…
View article: Association of CCR2 gene polymorphism with chronic kidney disease in the North Indian population
Association of CCR2 gene polymorphism with chronic kidney disease in the North Indian population Open
Chronic kidney disease (CKD), characterized by decreased renal function, is associated with an underlying elevated renal inflammatory state. The chemokine receptor 2 (CCR2) mediates leukocyte chemoattraction in the initiation and amplifica…
View article: Association of Genetic Polymorphisms in Base excision Repair Pathways and Cervical Cancer Risk Factors in a Tertiary Care Centre
Association of Genetic Polymorphisms in Base excision Repair Pathways and Cervical Cancer Risk Factors in a Tertiary Care Centre Open
Background and Objective: Cervical cancer is one of the most frequent neoplastic disorders affecting women, with about half a million new cases diagnosed globally each year. Reduced DNA repair capacity (DRC) is linked to an increased risk …
View article: Helicobacter pylori associated gallbladder diseases and its progression to gallbladder cancer: A mini review
Helicobacter pylori associated gallbladder diseases and its progression to gallbladder cancer: A mini review Open
Helicobacter pylori (H. pylori), is a spiral shaped gram-negative bacterium; H. pylori infection affects 60% of the population in India. H. pylori infection is one of the reasons of gastric inflammation, which results in duodenal ulcer, pe…
View article: Association of Single Nucleotide Polymorphism in OCT1 and OCT3 Genes with the Efficacy of Metformin Response in North Indian Type 2 Diabetes Mellitus Patients.
Association of Single Nucleotide Polymorphism in OCT1 and OCT3 Genes with the Efficacy of Metformin Response in North Indian Type 2 Diabetes Mellitus Patients. Open
Purpose Interindividual variation in efficacy of metformin among type 2 diabetes mellitus (T2DM) patients have been associated with several genetic variants. Understanding the genetic pathways involved in pharmacodynamics of metformin can …
View article: Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy
Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy Open
Purpose: Diabetic nephropathy (DN) affects almost 40% of diabetic patients and is clinically categorized by declining glomerular filtration rate, proteinuria and hypertension, ultimately leads to renal failure. Genome-wide association stud…
View article: Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases
Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases Open
Background: Diabetes mellitus (DM) is an array of metabolic diseases, which results from deregulation in insulin secretion or its action leading to abnormally high levels of blood sugar associated with long-term damage, organs failure, esp…
View article: PROSTATE CANCER AND DIABETES: BIOLOGY OR DETECTION BIAS?
PROSTATE CANCER AND DIABETES: BIOLOGY OR DETECTION BIAS? Open
Prostate cancer and diabetes are the two highly prevalent health problems in men worldwide and have a high mortality rates but their association is quite complex and contradictory. This review reported several population based studies whic…
View article: IMPACT OF OXIDATIVE STRESS IN THE PATHOGENESIS OF CERVICAL CANCER: THERAPEUTIC APPROCHES
IMPACT OF OXIDATIVE STRESS IN THE PATHOGENESIS OF CERVICAL CANCER: THERAPEUTIC APPROCHES Open
Cervical cancer (CC) is acknowledged as the most ubiquitous carcinoma among females along with the utmost prevalence in developing nations. The major cause of CC is HPV exposure, especially HPV16 and 18. Inflammation is linked to the carci…
View article: Genetic polymorphisms of IL6 gene –174G > C and –597G > A are associated with the risk of COVID‐19 severity
Genetic polymorphisms of IL6 gene –174G > C and –597G > A are associated with the risk of COVID‐19 severity Open
Coronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages, which mediates an inflammatory response, is frequently increased and …
View article: Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19
Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19 Open
Background Coronavirus disease 2019 (COVID-19) is an ongoing pandemic which has emerged as a new challenge for the medical sciences. Severity of COVID-19 is mostly determined with overexpressed proinflammatory cytokines eventually leading …
View article: Clinical implications of PON1 (rs662) and TNF-α (rs1799964) genes polymorphism in patients with coronary artery disease
Clinical implications of PON1 (rs662) and TNF-α (rs1799964) genes polymorphism in patients with coronary artery disease Open
Background Coronary artery disease (CAD) is the most common kind of heart problem, currently became one of the leading causes of death worldwide and is predicted to persist so for the next 20 years. The global risk factors to CAD include a…
View article: Role of Nanotechnology in Animal Nutrition, Health and Reproduction
Role of Nanotechnology in Animal Nutrition, Health and Reproduction Open
Nanotechnology is considered the most exponential technology in the veterinary sciences, especially animal breeding. It has also worked wonders in providing good habitual conditions and a properly livable environment for animals supported …
View article: Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells Open
Cancer progression is linked to abnormal epigenetic alterations such as DNA methylation and histone modifications. Since epigenetic alterations, unlike genetic changes, are heritable and reversible, they have been considered as interesting…
View article: Genetic Variants and Drug Efficacy in Tuberculosis: A Step toward Personalized Therapy
Genetic Variants and Drug Efficacy in Tuberculosis: A Step toward Personalized Therapy Open
View article: Genetic Variants in Interleukin-10 Gene Association with Susceptibility and Cervical Cancer Development: A Case Control Study
Genetic Variants in Interleukin-10 Gene Association with Susceptibility and Cervical Cancer Development: A Case Control Study Open