Explanipedia

Longitudinal functional connectivity during rest and task is differentially related to Alzheimer’s pathology and episodic memory in older adults Open

Larissa Fischer, Jenna N. Adams, Eóin N. Molloy, Jennifer Tremblay‐Mercier, Jordana Remz , et al. · 2025

Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies Open

Abbas Sohrabpour, Darko Sarovic, Henrik Zetterberg, Matti Hämäläinen, Sylvain Baillet , et al. · 2025

We conducted a review of the electrophysiological manifestations of Alzheimer's disease (AD) as captured by electroencephalography (EEG) and magnetoencephalography (MEG), with a focus on tracking their evolution through disease progression…

Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer’s disease pathology Open

Alfie Wearn, Ilana R. Leppert, Giulia Baracchini, Colleen Hughes, Jennifer Tremblay‐Mercier , et al. · 2025

Hippocampal degeneration is a feature of both normal aging and Alzheimer’s disease (AD). Prior to macroscopic degeneration, microstructural changes occur such as demyelination, iron deposition, or subtle atrophy, which can be characterized…

Lower Bound Estimates for Electrophysiological Power Dissipation in Human Gray Matter Open

Vikram Nathan, Malte B. Höltershinken, Emily Hill, Carsten H. Wolters, Sylvain Baillet · 2025

The human brain is popularly described as remarkably energy efficient, with its metabolic power consumption estimated at approximately 20 watts (W). Biophysical models have partitioned this power budget across distinct cellular processes, …

The PREVENT‐AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond Open

Sylvia Villeneuve, Judes Poirier, John C.S. Breitner, Jennifer Tremblay‐Mercier, Jordana Remz , et al. · 2025

The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT‐AD) is an investigator‐driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic …

Exploring Deep Magnetoencephalography via Thalamo‐Cortical Sleep Spindles Open

Gregory F. Rattray, Hugo R. Jourde, Sylvain Baillet, Emily B. J. Coffey · 2025

Subcortical brain regions like the thalamus are integral to numerous sensory and cognitive functions. Magnetoencephalography (MEG) enables the study of widespread brain networks with high temporal resolution, but the degree to which deep s…

Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers Open

Jonathan Gallego-Rudolf, Alex I. Wiesman, Yara Yakoub, Henrik Zetterberg, Kaj Blennow , et al. · 2025

Alzheimer’s disease (AD) develops over a prolonged asymptomatic phase marked by silent pathology. Identifying cognitively unimpaired individuals likely to progress to mild cognitive impairment (MCI) is essential for early intervention. We …

sEEG-Suite: An Interactive Pipeline for Semi-Automated Contact Localization and Anatomical Labeling with Brainstorm Open

Chinmay Chinara, Raymundo Cassani, Takfarinas Medani, Anand A. Joshi, Samuel Médina Villalon , et al. · 2025

Summary Stereoelectroencephalography (sEEG) is a critical tool for mapping epileptic networks in patients with drug-resistant epilepsy. Accurate localization and labeling of sEEG contacts are essential for identifying the seizure onset zon…

A Hypothesis-First Framework for Mechanistic Model Evaluation and Selection in Neuroimaging Open

Dominic Boutet, Sylvain Baillet · 2025

Neuroimaging provides rich measurements of brain structure and neural activity, but turning these data into mechanistic insight remains difficult. Statistical models quantify associations without much considerations for how they arise, whe…

Articulatory Perturbation Disrupts Sensorimotor Integration During Categorical Speech Perception Open

Olivia Bizimungu, Lucie Ménard, Sylvain Baillet · 2025

Growing evidence suggests that articulatory representations in the sensorimotor system contribute to speech perception, but their functional relevance remains unclear. Here, we investigated the impact of altered articulatory feedback on ph…

Alpha oscillations mediate inhibitory control and perceptual transitions during binocular rivalry Open

Eric Mokri, Jason da Silva Castanheira, Sylvain Baillet, Janine D. Mendola · 2025

Binocular rivalry is a visual phenomenon that involves alternating percepts despite stable input, providing a window into perceptual processing and neural dynamics. We examined changes in alpha band activity (8-13 Hz) using magnetoencephal…

Genetic foundations of interindividual neurophysiological variability Open

Jason da Silva Castanheira, Jonathan Poli, Justine Y. Hansen, Bratislav Mišić, Sylvain Baillet · 2025

Neurophysiological brain activity shapes cognitive functions and individual traits. Here, we investigated the extent to which individual neurophysiological properties are genetically determined and how these adult traits align with cortica…

The PREVENT-AD cohort: accelerating Alzheimer’s disease research and treatment in Canada and beyond Open

Sylvia Villeneuve, Judes Poirier, John C.S. Breitner, Jennifer Tremblay‐Mercier, Jordana Remz , et al. · 2025

The PREVENT-AD is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than…

Neurophysiological encoding of aversive prediction errors Open

Raghavan Gopalakrishnan, Claire Sonneborn, Sylvain Baillet, André G. Machado, Tor D. Wager , et al. · 2025

Aversive prediction error (PE) brain signals generated by unexpected pain or pain absence are crucial for learning to avoid future pain. Yet, the detailed neurophysiological origins of PE signaling remain unclear. In this study, we combine…

Stimulus-dependent delay of perceptual filling-in by microsaccades Open

Max Levinson, Christopher C. Pack, Sylvain Baillet · 2025

Perception is a function of both stimulus features and active sensory sampling. The illusion of perceptual filling-in occurs when eye gaze is kept still: visual boundary perception may fail, causing adjacent visual features to remarkably m…

Adversarial testing of global neuronal workspace and integrated information theories of consciousness Open

Oscar Ferrante, Urszula Górska, Simon Henin, Rony Hirschhorn, Aya Khalaf , et al. · 2025

Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation Open

Atefeh Asadi, Alex I. Wiesman, Christoph Wiest, Sylvain Baillet, Huiling Tan , et al. · 2025

Neuromodulation therapy comprises a range of non-destructive and adjustable methods for modulating neural activity using electrical stimulations, chemical agents, or mechanical interventions. Here, we discuss how electrophysiological brain…

Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease Open

Christina Tremblay, Shady Rahayel, Alexandre Pastor‐Bernier, Frédéric St‐Onge, Andrew Vo , et al. · 2025

Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic…

Theta‐ and alpha‐band functional connectivity are associated with longitudinal tau accumulation in asymptomatic individuals expressing Aβ pathology Open

Jonathan Gallego Rudolf, Alex I. Wiesman, Sylvain Baillet, Sylvia Villeneuve · 2024

Background Recent studies suggest that tau pathology spreads between functionally connected (FC) brain regions. The accumulation of amyloid‐beta (Aβ) promotes neural hyper‐activity in asymptomatic older adults, which might enhance tau spre…

Theta‐ and alpha‐band functional connectivity are associated with longitudinal tau accumulation in asymptomatic individuals expressing Aβ pathology Open

Jonathan Gallego Rudolf, Alex I. Wiesman, Sylvain Baillet, Sylvia Villeneuve · 2024

Background Recent studies suggest that tau pathology spreads between functionally connected (FC) brain regions. The accumulation of amyloid‐beta (Aß) promotes neural hyper‐activity in asymptomatic older adults, which might enhance tau spre…

The Lifespan Evolution of Individualized Neurophysiological Traits Open

Jason da Silva Castanheira, Alex I. Wiesman, Margot J. Taylor, Sylvain Baillet · 2024

How do neurophysiological traits that characterize individuals evolve across the lifespan? To address this question, we analyzed brief, task-free magnetoencephalographic recordings from over 1,000 individuals aged 4-89. We found that neuro…

Stimulus-dependent delay of perceptual filling-in by microsaccades Open

Max Levinson, Christopher C. Pack, Sylvain Baillet · 2024

Perception is a function of both stimulus features and active sensory sampling. The illusion of perceptual filling -in occurs when eye gaze is kept still: visual boundary perception may fail, causing adjacent visual features to remarkably …

Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults Open

Jonathan Gallego-Rudolf, Alex I. Wiesman, Alexa Pichet Binette, Sylvia Villeneuve, Sylvain Baillet · 2024

Eccentricity, but not color contrast, influences microsaccadic prevention of visual fading Open

Max Levinson, Christopher C. Pack, Sylvain Baillet · 2024

Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease Open

Alex I. Wiesman, Victoria Madge, Edward A. Fon, Alain Dagher, D. Louis Collins , et al. · 2024

Parkinson’s disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN do…

One hundred years of EEG for brain and behaviour research Open

Faisal Mushtaq, Dominik Welke, Ann Gallagher, Yuri G. Pavlov, Layla Kouara , et al. · 2024

Model selection for spectral parameterization Open

Luc Wilson, Jason da Silva Castanheira, Benjamin Lévesque Kinder, Sylvain Baillet · 2024

Neurophysiological brain activity comprises rhythmic (periodic) and arrhythmic (aperiodic) signal elements, which are increasingly studied in relation to behavioral traits and clinical symptoms. Current methods for spectral parameterizatio…

Genetic Foundations of Inter-individual Neurophysiological Variability Open

Jason da Silva Castanheira, Jonathan Poli, Justine Y. Hansen, Bratislav Misic, Sylvain Baillet · 2024

Neurophysiological brain activity shapes cognitive functions and individual traits. Here, we investigated the extent to which individual neurophysiological properties are genetically determined and how these adult traits align with cortica…

Neurochemical organization of cortical proteinopathy and neurophysiology along the Alzheimer's disease continuum Open

Alex I. Wiesman, Jonathan Gallego‐Rudolf, Sylvia Villeneuve, Sylvain Baillet, Tony W. Wilson · 2024

INTRODUCTION Despite parallel research indicating amyloid‐β accumulation, alterations in cortical neurophysiological signaling, and multi‐system neurotransmitter disruptions in Alzheimer's disease (AD), the relationships between these phen…

Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood Open

Gary R. Turner, Patrick Hewan, Alfie Wearn, Roel van Dooren, Lindsay E. Wyatt , et al. · 2024

Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in ol…

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