Sylvain Baulande
YOU?
Author Swipe
View article: Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response
Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response Open
View article: Common origin for effector and regulatory follicular and tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer
Common origin for effector and regulatory follicular and tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer Open
Tumor-invaded lymph nodes (LNs) serve as critical hubs for anti-tumor immunity, yet their role in orchestrating immune responses remains poorly understood. Using integrated single-cell RNA sequencing, T cell receptor sequencing, and chroma…
View article: Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation
Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation Open
Although metabolic benefits of glycolysis have been extensively described in tumor cells, the extra-metabolic functions linked to this energetic pathway in tumor growth and cell proliferation have not been clearly established yet. Recently…
View article: Author Correction: A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript
Author Correction: A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript Open
View article: Scandare: A Successful, Flexible, Prospective, and Longitudinal Biobank Framework
Scandare: A Successful, Flexible, Prospective, and Longitudinal Biobank Framework Open
Patient-specific tumor heterogeneity is a significant challenge to understanding and treating cancer. The availability of multi-omic data in large public repositories has powered breakthroughs in precision medicine by enabling diversified …
View article: A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript
A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript Open
Pathogenicity assessment of genetic variants is the cornerstone of genetic counselling. Copy gains of exons are challenging, as pathogenicity depends on the localization of the additional exons. Eight patients form six families carried cop…
View article: A pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
A pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription Open
Germline monoallelic truncating mutations in BRCA2, a critical mediator of homologous recombination (HR), predispose individuals to breast and ovarian cancer. While tumorigenesis is usually attributed to biallelic inactivation, emerging ev…
View article: A recurrent pathogenic <i>BRCA2</i> truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription
A recurrent pathogenic <i>BRCA2</i> truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription Open
Summary Germline monoallelic truncating mutations in BRCA2, a critical mediator of homologous recombination (HR), predispose individuals to breast and ovarian cancer. While tumorigenesis is usually attributed to biallelic inactivation, eme…
View article: Pathogenic Viruses, Genome Integrations, and Viral::Human Chimeric Transcripts Detected by VirusIntegrationFinder Across >30k Human Tumor and Normal Samples
Pathogenic Viruses, Genome Integrations, and Viral::Human Chimeric Transcripts Detected by VirusIntegrationFinder Across >30k Human Tumor and Normal Samples Open
Viruses are a leading cause of human morbidity and mortality. Certain viruses, including human papillomaviruses (HPVs), play a significant role in the etiology of cancer. Detection of viral DNA insertions in the human genome from next gene…
View article: The release of sexual conflict after sex loss is associated with evolutionary changes in gene expression
The release of sexual conflict after sex loss is associated with evolutionary changes in gene expression Open
Sexual conflict can arise because males and females, while sharing most of their genome, can have different phenotypic optima. Sexually dimorphic gene expression may help reduce conflict, but the expression of many genes may remain sub-opt…
View article: TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion
TNFR2 blockade promotes antitumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion Open
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, highly resistant to standard chemotherapy and immunotherapy. Regulatory T cells (Tregs) expressing tumor necrosis factor α receptor 2 (TNFR2) contrib…
View article: Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance Open
International audience
View article: CCG interruptions are unstable and hypermethylated in DM1 patients
CCG interruptions are unstable and hypermethylated in DM1 patients Open
Myotonic dystrophy type 1 (DM1) exhibits highly heterogeneous clinical manifestations caused by an unstable CTG repeat expansion reaching up to 4,000 CTG. The dynamics of CTG repeats and clinical variability depends on the CTG repeat numbe…
View article: Cellular origin and clonal evolution of human dedifferentiated liposarcoma
Cellular origin and clonal evolution of human dedifferentiated liposarcoma Open
Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells.…
View article: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance Open
These findings suggest that ACBP/DBI acts as an endogenous immune suppressor. We conclude that elevation of ACBP/DBI constitutes a risk factor for the development of cancer and that ACBP/DBI is an actionable target for improving cancer imm…
View article: An extra-glycolytic function for hexokinase 2 as an RNA-binding protein regulating<i>SOX10</i>mRNA translation in melanoma
An extra-glycolytic function for hexokinase 2 as an RNA-binding protein regulating<i>SOX10</i>mRNA translation in melanoma Open
Several studies have reported the importance of aerobic glycolysis in melanoma development. Although metabolic benefits of glycolysis have been extensively described in tumor cells, the extra-metabolic functions linked to this energetic pa…
View article: Supplementary Table 2 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 2 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 2
View article: Supplementary Table 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 1
View article: Supplementary Table Legend 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table Legend 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table Legend
View article: Supplementary Table 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 1
View article: Supplementary Table 3 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 3 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 3
View article: Supplementary Table Legend 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table Legend 1 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table Legend
View article: Supplementary Table 4 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 4 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 4
View article: Supplementary Table 3 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 3 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 3
View article: Supplementary Table 2 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 2 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 2
View article: SupplemetaryFigure1-5 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
SupplemetaryFigure1-5 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
SupplemetaryFigure12345
View article: SupplemetaryFigure1-5 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
SupplemetaryFigure1-5 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
SupplemetaryFigure12345
View article: Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Purpose:The study of cell-free DNA (cfDNA) enables sequential analysis of tumor cell–specific genetic alterations in patients with neuroblastoma.Experimental Design:Eighteen patients with relapsing neuroblastoma having received lorlatinib,…
View article: Supplementary Table 4 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Supplementary Table 4 from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Supplementary Table 4
View article: Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy
Data from Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving <i>ALK</i>-Targeted Therapy Open
Purpose:The study of cell-free DNA (cfDNA) enables sequential analysis of tumor cell–specific genetic alterations in patients with neuroblastoma.Experimental Design:Eighteen patients with relapsing neuroblastoma having received lorlatinib,…