Sylvain Lehmann
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View article: Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia Open
View article: Impact of preanalytical delay on the performance of plasma Aβ42, Aβ42/40, p‐tau217, and p‐tau217/Aβ42 in detecting brain amyloidosis in the ALZAN cohort
Impact of preanalytical delay on the performance of plasma Aβ42, Aβ42/40, p‐tau217, and p‐tau217/Aβ42 in detecting brain amyloidosis in the ALZAN cohort Open
BACKGROUND Alzheimer disease (AD), the leading cause of dementia, has increased interest in the development of blood‐based biomarkers for early diagnosis and monitoring. The plasma amyloid beta (Aβ)42/Aβ40 ratio and phosphorylated tau (p‐t…
View article: Beyond amyloid and tau: synaptic and neurodegenerative biomarkers shape MCI progression
Beyond amyloid and tau: synaptic and neurodegenerative biomarkers shape MCI progression Open
Summary Background Accurate prediction of which patients with mild cognitive impairment (MCI) will progress to Alzheimer’s disease (AD) remains a major unmet clinical need. Current biomarkers detect amyloid pathology with high accuracy but…
View article: Targeting Dysregulated Epigenetic and Transcription Factor Networks in KMT2A-Rearranged AML Using iPSC Models
Targeting Dysregulated Epigenetic and Transcription Factor Networks in KMT2A-Rearranged AML Using iPSC Models Open
View article: MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
MALNC: a new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response Open
View article: Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory <scp>AML</scp>—A Population‐Based Study
Second‐ and Third‐Line Salvage Chemotherapy Followed by Allogeneic Stem Cell Transplantation Leads to High Survival Rates in Primary Refractory <span>AML</span>—A Population‐Based Study Open
Refractory acute myeloblastic leukemia (AML) is poorly studied. In this study, we characterized primary refractory AML and investigated treatment and outcome in a population‐based setting. Based on all AML patients receiving intensive indu…
View article: Generation of two isogenic-corrected control cell lines (IRMBi001-A-1; IRMBi001-A-2) from Autosomal dominant Alzheimer’s disease patient-derived iPSCs carrying a G217D mutation in presenilin 1 gene
Generation of two isogenic-corrected control cell lines (IRMBi001-A-1; IRMBi001-A-2) from Autosomal dominant Alzheimer’s disease patient-derived iPSCs carrying a G217D mutation in presenilin 1 gene Open
View article: Comparative performance of plasma pTau181/Aβ42, pTau217/Aβ42 ratios, and individual measurements in detecting brain amyloidosis
Comparative performance of plasma pTau181/Aβ42, pTau217/Aβ42 ratios, and individual measurements in detecting brain amyloidosis Open
Fondation Research Alzheimer (ALZAN projet), AXA Mécénat Santé (INTERVAL Project), Fondation pour la Recherche Médicale (FRM, team Proteinopathies).
View article: A six-year risk assessment for dementia and Alzheimer's disease in the general population through immunoprecipitation-mass spectrometry plasma amyloid quantification
A six-year risk assessment for dementia and Alzheimer's disease in the general population through immunoprecipitation-mass spectrometry plasma amyloid quantification Open
View article: Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers
Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers Open
Importance Blood phosphorylated tau 217 (p-tau217) showed good performance in predicting brain amyloidosis. However, the importance of detailed cognitive phenotyping in patients without dementia when interpreting p-tau217 results remains u…
View article: Comparative Performances of 4 Serum NfL Assays, pTau181, and GFAP in Patients With Amyotrophic Lateral Sclerosis
Comparative Performances of 4 Serum NfL Assays, pTau181, and GFAP in Patients With Amyotrophic Lateral Sclerosis Open
This study provides Class II evidence that serum NfL levels are useful in identifying over 80% of patients with ALS and predicting survival in patients with ALS compared with pTau181 and GFAP levels.
View article: Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia
Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia Open
Blood Hepcidin and NfL have limited interest in the clinical context of AD but determination of these biomarkers shows to be highly informative for the diagnosis of VaD. This result could have important implications for diagnosis and imple…
View article: Study protocol for the development and pilot-testing of a Self-assessment tool for the implementation of the European Standards of Care for Newborn Health (ESCNH)
Study protocol for the development and pilot-testing of a Self-assessment tool for the implementation of the European Standards of Care for Newborn Health (ESCNH) Open
Introduction In Europe, disparities exist in having access to optimal neonatal care. With the European Standards of Care for Newborn Health (ESCNH), evidence-based reference standards are available which provide guidance to improve the car…
View article: Clinical Application and Reporting of Neurofilament Quantification in Neurological Disorders: An International Overview
Clinical Application and Reporting of Neurofilament Quantification in Neurological Disorders: An International Overview Open
View article: Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia
Blood-based biomarkers and plasma Aβ assays in the differential diagnosis of Alzheimer’s disease and behavioral-variant frontotemporal dementia Open
Introduction The differentiation between Alzheimer’s disease (AD) and behavioral-variant frontotemporal dementia (bvFTD) can be complicated in the initial phase by shared symptoms and pathophysiological traits. Nevertheless, advancements i…
View article: Comparative performance of plasma pTau181/Aβ42, pTau217/Aβ42 ratios, and individual measurements in detecting brain amyloidosis
Comparative performance of plasma pTau181/Aβ42, pTau217/Aβ42 ratios, and individual measurements in detecting brain amyloidosis Open
Background Early detection of brain amyloidosis (Aβ+) is crucial for diagnosing Alzheimer’disease (AD) and optimizing patient management, especially in light of emerging treatments. While plasma biomarkers are promising, their combined dia…
View article: Large‐scale proteomic approach to stable isotope labeling kinetics (SILK) for studying protein turnover in blood and cerebrospinal fluid in Alzheimer’s disease
Large‐scale proteomic approach to stable isotope labeling kinetics (SILK) for studying protein turnover in blood and cerebrospinal fluid in Alzheimer’s disease Open
Background Protein metabolism and turnover can be monitored using tracer methods, notably stable isotope labeling kinetics (SILK) based on 13C‐leucine incorporation. This approach has been used in Alzheimer’s disease, specifically analyzin…
View article: International Initiative for Harmonization of Plasma Neurofilament light chain NfL clinical reporting in neurodegenerative diseases
International Initiative for Harmonization of Plasma Neurofilament light chain NfL clinical reporting in neurodegenerative diseases Open
Background The quantification of neurofilament light chain (NfL) in blood and cerebrospinal fluid (CSF) has proved useful in many contexts, for the diagnosis and prognosis of various neurological disorders. There is, however, a diversity o…
View article: Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS
Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS Open
BACKGROUND Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)‐derived measurements in Alzheimer's disease (AD) remain unclear. METHODS In a study population ( n = 127) of healthy older adult…
View article: A French multicenter analytical evaluation of the automated Lumipulse G sNfL blood assay (Fujirebio®) and its comparison to four other immunoassays for serum neurofilament light chain assessment in clinical settings
A French multicenter analytical evaluation of the automated Lumipulse G sNfL blood assay (Fujirebio®) and its comparison to four other immunoassays for serum neurofilament light chain assessment in clinical settings Open
View article: Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease
Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease Open
View article: The endolysosomal system in conventional and unconventional protein secretion
The endolysosomal system in conventional and unconventional protein secretion Open
Most secreted proteins are transported through the “conventional” endoplasmic reticulum–Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have…
View article: Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study
Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study Open
INTRODUCTION We investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. METHODS MCI ( N = 147) and AD…
View article: Enabling Population Protein Dynamics Through Bayesian Modeling
Enabling Population Protein Dynamics Through Bayesian Modeling Open
Motivation The knowledge of protein dynamics, or turnover, in patients provides invaluable information related to certain diseases, drug efficacy, or biological processes. A great corpus of experimental and computational methods has been d…
View article: Modeling the Simultaneous Dynamics of Proteins in Blood Plasma and the Cerebrospinal Fluid in Human <i>In Vivo</i>
Modeling the Simultaneous Dynamics of Proteins in Blood Plasma and the Cerebrospinal Fluid in Human <i>In Vivo</i> Open
The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling, such as in Alzheimer's disease, and to provide informative data regarding drug efficacy or certain biological processes. The ob…
View article: Climate Change Policies and Global Cooperation: Assessing the Role of International Organizations in Germany
Climate Change Policies and Global Cooperation: Assessing the Role of International Organizations in Germany Open
Purpose: The aim of the study was to analyze the climate change policies and global cooperation: assessing the role of international organizations in Germany. Methodology: This study adopted a desk methodology. A desk study research design…
View article: CD138 as a Specific CSF Biomarker of Multiple Sclerosis
CD138 as a Specific CSF Biomarker of Multiple Sclerosis Open
This study provides Class II evidence that CD138 distinguishes multiple sclerosis from other inflammatory neurologic disorders with an AUC of 0.85 (95% CI 0.75-0.95).
View article: Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment
Clinical value of plasma ALZpath pTau217 immunoassay for assessing mild cognitive impairment Open
Background Among plasma biomarkers for Alzheimer’s disease (AD), pTau181 and pTau217 are the most promising. However, transition from research to routine clinical use will require confirmation of clinical performance in prospective cohorts…
View article: Salivary Alpha-Synuclein to Differentiate Parkinson’s Disease from Drug Induced Parkinsonism and Controls Using ELISA
Salivary Alpha-Synuclein to Differentiate Parkinson’s Disease from Drug Induced Parkinsonism and Controls Using ELISA Open
Background: Alpha-synuclein is a promising biomarker for Parkinson’s disease (PD).
View article: Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study
Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study Open
STRUCTURED ABSTRACT INTRODUCTION We investigated the link between habitual caffeine intake with memory deficits and CSF AD biomarkers in Mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) patients. METHODS MCI (N=147) and AD (N=1…