Explanipedia

Insomnia, early and late rising are associated with small hippocampal volume and large white matter hyperintensity burden Open

Clémence Cavaillès, Sylvaine Artéro, Jerome J. Maller, Isabelle Jaussent, Yves Dauvilliers · 2025

Plasma amyloid-β is associated with suicidal ideation in older adults: a 15-year follow-up study Open

Ismaël Conejero, Isabelle Jaussent, Jorge López‐Castromán, Philippe Courtet, Sylvaine Artéro · 2024

International audience

Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study Open

Jeanne Duchesne, Isabelle Carrière, Sylvaine Artéro, Adam M. Brickman, Jerome J. Maller , et al. · 2023

In this population-based study in older adults, exposure was associated with increased risk of high WMH volume in the temporal lobe, strengthening the evidence on adverse effect on the brain. Further studies looking at different markers …

Is Hippocampal Volume a Relevant Early Marker of Dementia? Open

Mélissa Gentreau, Jerome J. Maller, Chantal Meslin, Fabienne Cyprien, Jorge López‐Castromán , et al. · 2023

Glucometabolic Changes Are Associated with Structural Gray Matter Alterations in Prodromal Dementia Open

Mélissa Gentreau, Christelle Reynès, Robert Sabatier, Jerome J. Maller, Chantal Meslin , et al. · 2022

Background: Glucometabolic changes, such as high glycemic load (GL) diet and insulin resistance (IR), are potential risk factor of Alzheimer’s disease (AD). Yet, the effect of these factors on brain alterations that contribute to AD pathol…

Dietary Glycemic Load and Plasma Amyloid-β Biomarkers of Alzheimer’s Disease Open

Mélissa Gentreau, Michel Raymond, Cécilia Samieri, Virginie Chuy, Catherine Féart , et al. · 2022

Previous studies have highlighted links between a high-glycemic-load (GL) diet and Alzheimer’s disease in apolipoprotein E ε4 (APOE4) carriers. However, the impact of high-GL diet on plasma amyloid-β (Aβ), an Alzheimer’s disease hallmark t…

Structural brain alterations in older adults exposed to early-life adversity Open

Marie‐Laure Ancelin, Isabelle Carrière, Sylvaine Artéro, Jerome J. Maller, Chantal Meslin , et al. · 2021

Short‐ and long‐term effects of glycaemic load on cognition, dementia risk and plasma Amyloid‐β levels Open

Mélissa Gentreau, Virginie Chuy, Catherine Féart, Cécilia Samieri, Michel Raymond , et al. · 2020

Background In animal models, carbohydrates increase β‐amyloid aggregation, tau phosphorylation and hippocampal atrophy which lead to the development of Alzheimer’s disease (AD). In epidemiological studies, cross‐sectional analyses on the i…

Is hippocampal volume an accurate and reliable early marker of Alzheimer’s disease? Open

Mélissa Gentreau, Jerome J. Maller, Chantal Meslin, Fabienne Cyprien, Karen Ritchie , et al. · 2020

Background It is challenging to predict when and which individuals will progress to Alzheimer's disease (AD) to facilitate enrollment in clinical trials. Hippocampal volume (HV) considered as a fundamental structure for cognition is one of…

High Glycemic Load Is Associated with Cognitive Decline in Apolipoprotein E ε4 Allele Carriers Open

Mélissa Gentreau, Michel Raymond, Virginie Chuy, Cécilia Samieri, Catherine Féart , et al. · 2020

Recent evidence suggests that a high glycemic load (GL) diet is a risk factor for dementia, especially among apolipoprotein E ε4 allele (APOE4) carriers, while its association with cognitive decline is poorly known. Here, we investigated t…

Refined carbohydrate‐rich diet is associated with long‐term risk of dementia and Alzheimer's disease in apolipoprotein E ε4 allele carriers Open

Mélissa Gentreau, Virginie Chuy, Catherine Féart, Cécilia Samieri, Karen Ritchie , et al. · 2020

Introduction In animal models, refined carbohydrates (RF) worsen Alzheimer's disease (AD). However, the long‐term effects of high RF intake on the risk of dementia and AD are poorly described in epidemiological studies. Moreover, the inter…

Structural brain changes with lifetime trauma and re-experiencing symptoms is <i>5-HTTLPR</i> genotype-dependent Open

Marie‐Laure Ancelin, Isabelle Carrière, Sylvaine Artéro, Jerome J. Maller, Chantal Meslin , et al. · 2020

Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This s…

Commentary on “Smaller Hippocampal Volume in Current But Not in Past Depression in Comparison to Healthy Controls: Minor Evidence From an Older Adults Sample” Open

Raffaella Calati, Maura Boldrini, Ismaïl Bensassi, Jerome J. Maller, Chantal Meslin , et al. · 2019

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Lifetime major depression and grey-matter volume Open

Marie‐Laure Ancelin, Isabelle Carrière, Sylvaine Artéro, Jerome J. Maller, Chantal Meslin , et al. · 2018

Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how these alterations might be affected by age at onset or genetic vulnerability. This study examines whether lifet…

Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults Open

Fabienne Cyprien, Philippe Courtet, Jerome J. Maller, Chantal Meslin, Karen Ritchie , et al. · 2018

Chronic systemic low-grade inflammation is associated with aging, but little is known on whether age-related inflammation affects brain structure, particularly white matter. The current study tested the hypothesis that in older adults with…

Smaller hippocampal volume in current but not in past depression in comparison to healthy controls: Minor evidence from an older adults sample Open

Ismaïl Bensassi, Jorge López‐Castromán, Jerome J. Maller, Chantal Meslin, Marilyn Wyart , et al. · 2018

[P4–348]: LATE‐LIFE CYNICAL DISTRUST PREDICTS INCIDENT ALZHEIMER's DISEASE: A 10‐YEAR FOLLOW‐UP STUDY Open

Sylvaine Artéro, Claudine Berr · 2017

Personnality traits have been linked to higher risk of dementia. We investigated the asociation between cynical distrust and incident Alzheimer's Disease (AD) over 10 years. We studied 1388 individuals without dementia from a cohort of com…

Modifiable Risk Factors for Prevention of Dementia in Midlife, Late Life and the Oldest-Old: Validation of the LIBRA Index Open

Stephanie J. B. Vos, Martin P.J. van Boxtel, Olga J.G. Schiepers, Kay Deckers, Marjolein de Vugt , et al. · 2017

Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual’s prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in mi…

Predicting dementia using socio-demographic characteristics and the Free and Cued Selective Reminding Test in the general population Open

Thibault Mura, Marieta Baramova, Audrey Gabelle, Sylvaine Artéro, Jean‐François Dartigues , et al. · 2017

Contents Vol. 86, 2017 Open

Giovanni A. Fava, Jenny Guidi, Chiara Rafanelli, Karl Rickels, Fiammetta Cosci , et al. · 2017

Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly Open

Raffaella Calati, Jerome J. Maller, Chantal Meslin, Jorge López‐Castromán, Karen Ritchie , et al. · 2016

In the elderly a previous (approximately 40 years before) serious SLE could be associated with long-term volume reduction in the ICC, independently of psychopathology.

Corpus callosum integrity is affected by mood disorders and also by the suicide attempt history: A diffusion tensor imaging study Open

Fabienne Cyprien, Nicolas Menjot de Champfleur, Jérémy Deverdun, Émilie Olié, Emmanuelle Le Bars , et al. · 2016

Excessive daytime sleepiness and antipathogen drug consumption in the elderly: a test of the immune theory of sleep Open

Claire Berticat, Frédéric Thomas, Yves Dauvilliers, Isabelle Jaussent, Karen Ritchie , et al. · 2016

High Level of Depressive Symptoms at Repeated Study Visits and Risk of Coronary Heart Disease and Stroke over 10 Years in Older Adults: The Three‐City Study Open

R. Péquignot, Carole Dufouil, Christof Prugger, Karine Pérès, Sylvaine Artéro , et al. · 2016

Backround Baseline depressive symptoms have been consistently associated with the onset of cardiovascular disease ( CVD ). Objectives Since depressive symptoms vary over time in elderly persons, and to help clarify whether or not depressio…

GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations Open

Joanne Ryan, Sylvaine Artéro, Isabelle Carrière, Jerome J. Maller, Chantal Meslin , et al. · 2015

5‐HTTLPR genotype, asthma, diabetes and late‐life depression in an older French population Open

Lorraine Omari‐Asor, Robert Stewart, Sylvaine Artéro, Karen Ritchie · 2015

Objective Associations between environmental risk factors and depression have been reported to be stronger in people with the S allele of the S/L polymorphism in the serotonin transporter gene‐linked promoter region (5‐HTTLPR); however, mo…

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