Sylvaine Guérit
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View article: Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke
Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke Open
View article: Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke Open
View article: Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke Open
Blood-brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke. Dysregulation of multiple neurovascular unit (NVU)…
View article: PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models
PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models Open
View article: Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses
Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses Open
Background Tissue plasminogen activator (tPA) is a serine protease involved in fibrinolysis. It is released by endothelial cells, but also expressed by neurons and glial cells in the central nervous system (CNS). Interestingly, this enzyme…
View article: Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance
Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance Open
Maintenance of the endothelial blood-brain-barrier (BBB) through Wnt/β-catenin signalling is essential for neuronal function. The cells however, providing Wnt growth factors at the adult neurovascular unit (NVU) are poorly explored. Here w…
View article: HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis
HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis Open
View article: Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin
Nonionotropic Action of Endothelial NMDA Receptors on Blood–Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin Open
Increase in blood–brain barrier (BBB) permeability is a crucial step in neuroinflammatory processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs), expressed on cerebral endothelial cells forming the BBB, regulate immune…
View article: Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers
Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers Open
Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS.Recent rediscoveries of lymphatic vessels within…
View article: Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice
Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice Open
The circumventricular organs (CVOs) in the central nervous system (CNS) lack a vascular blood-brain barrier (BBB), creating communication sites for sensory or secretory neurons, involved in body homeostasis. Wnt/β-catenin signaling is esse…
View article: Author response: Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice
Author response: Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The circumventricular organs …
View article: Deciphering the complex role of thrombospondin-1 in glioblastoma development
Deciphering the complex role of thrombospondin-1 in glioblastoma development Open
View article: An <em>In Vivo</em> Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers
An <em>In Vivo</em> Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers Open
Blood-brain barrier (BBB) is a specialized barrier that protects the brain microenvironment from toxins and pathogens in the circulation and maintains brain homeostasis. The principal sites of the barrier are endothelial cells of the brain…
View article: Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Open
View article: Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma
Blood-Brain Barrier Breakdown Determines Differential Therapeutic Outcome in Genetically Diverse Forms of Medulloblastoma Open