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View article: In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Open
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a…
View article: An evolved AAV variant enables efficient genetic engineering of murine T cells
An evolved AAV variant enables efficient genetic engineering of murine T cells Open
Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin…