Explanipedia

Transcriptional coregulator ZMIZ1 modulates estrogen responses that are essential for healthy endometrial function Open

Sylvia C. Hewitt, F Orellana, Yong Song, Ramakrishna Kommagani, John P. Lydon · 2025

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a coregulator of uteri…

Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males Open

Zhenqi Zhou, Timothy M. Moore, Alexander R. Strumwasser, Vicent Ribas, Hirotaka Iwasaki , et al. · 2025

From cup to dish: how to make and use endometrial organoid and stromal cultures derived from menstrual fluid Open

Sylvia C. Hewitt, Mackenzie J. Dickson, N EDWARDS, Kathleen Hampton, Stavros Garantziotis , et al. · 2023

Diseases impacting the female reproductive tract pose a critical health concern. The establishment of in vitro models to study primary endometrial cells is crucial to understanding the mechanisms that contribute to normal endometrial funct…

Chromatin architectural factor <span>CTCF</span> is essential for progesterone‐dependent uterine maturation Open

Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San‐Pin Wu, John P. Lydon , et al. · 2023

Receptors for estrogen and progesterone frequently interact, via Cohesin/CTCF loop extrusion, at enhancers distal from regulated genes. Loss‐of‐function CTCF mutation in >20% of human endometrial tumors indicates its importance in uterine …

The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids Open

Sylvia C. Hewitt, San‐Pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson , et al. · 2022

Endometrial health is affected by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor α (ESR1) cistromes and transcriptomes of endometrial biops…

A Novel Mouse Model to Analyze Non-Genomic ERα Physiological Actions Open

Yukitomo Arao, Artiom Gruzdev, Gregory J. Scott, Manas K. Ray, Lauren J. Donoghue , et al. · 2022

Nongenomic effects of estrogen receptor α (ERα) signaling have been described for decades. Several distinct animal models have been generated previously to analyze the nongenomic ERα signaling (eg, membrane-only ER, and ERαC451A). However,…

Progesterone Signaling in Endometrial Epithelial Organoids Open

Sylvia C. Hewitt, San‐Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer , et al. · 2022

For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding c…

The estrogen receptor α cistrome in human endometrium and epithelial organoids Open

Sylvia C. Hewitt, San‐Pin Wu, Tianyuan Wang, Mita Ray, Marja Brolinson , et al. · 2022

Context Endometrial health is impacted by molecular processes that underlie estrogen responses. Objective To define estrogen regulation of endometrial function by integrating the estrogen receptor alpha (ESR1) cistrome and transcriptome of…

Progesterone Signaling in Endometrial Epithelial Organoids Open

Sylvia C. Hewitt, San‐Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer , et al. · 2022

For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding c…

Cell‐type specific analysis of physiological action of estrogen in mouse oviducts Open

Emily A. McGlade, Gerardo G. Herrera, Kalli K. Stephens, Sierra L. W. Olsen, Sarayut Winuthayanon , et al. · 2021

One of the endogenous estrogens, 17β‐estradiol (E 2 ) is a female steroid hormone secreted from the ovary. It is well established that E 2 causes biochemical and histological changes in the uterus. However, it is not completely understood …

Cell-type specific analysis of physiological action of estrogen in mouse oviducts Open

Emily A. McGlade, Gerardo G. Herrera, Kalli K. Stephens, Sierra L. W. Olsen, Sarayut Winuthayanon , et al. · 2020

One of the endogenous estrogens, 17β-estradiol (E 2 ) is a female steroid hormone secreted from the ovary. It is well established that E 2 causes biochemical and histological changes in the uterus. The oviduct response to E 2 is virtually …

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating <i>Polg1</i> and mitochondrial remodeling Open

Zhenqi Zhou, Timothy M. Moore, Brian G. Drew, Vicent Ribas, Jonathan Wanagat , et al. · 2020

ERα gene expression is heritable in humans and prevents obesity in mice by improving mitochondrial function via adipocyte Polg1 expression.

Peri- and Postpubertal Estrogen Exposures of Female Mice Optimize Uterine Responses Later in Life Open

Sylvia C. Hewitt, Marleny Carmona, K. Grace Foley, Lauren J. Donoghue, Sydney L Lierz , et al. · 2020

At birth, all female mice, including those that either lack estrogen receptor α (ERα-knockout) or that express mutated forms of ERα (AF2ERKI), have a hypoplastic uterus. However, uterine growth and development that normally accompany puber…

Estrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice Open

Sylvia C. Hewitt, Sara A. Grimm, San‐Pin Wu, Francesco J. DeMayo, Kenneth S. Korach · 2020

Estrogen receptor α (ERα) modulates gene expression by interacting with chromatin regions that are frequently distal from the promoters of estrogen-regulated genes. Active chromatin-enriched "super-enhancer" (SE) regions, mainly observed i…

Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus Open

Gerardo G. Herrera, Sydney L Lierz, Emily A. Harris, Lauren J. Donoghue, Sylvia C. Hewitt , et al. · 2019

Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confoun…

A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Igf1 (insulin-like growth factor 1) Open

Sylvia C. Hewitt, Sydney L Lierz, Marleny Garcia, Katherine J. Hamilton, Artiom Gruzdev , et al. · 2019

Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome Open

Laurel A. Coons, Adam Burkholder, Sylvia C. Hewitt, Donald P. McDonnell, Kenneth S. Korach · 2019

Negative elongation factor is essential for endometrial function Open

Sylvia C. Hewitt, Rong Li, Nyssa Adams, Wipawee Winuthayanon, Katherine J. Hamilton , et al. · 2018

Pausing of RNA polymerase II (Pol II) during early transcription, mediated by the negative elongation factor (NELF) complex, allows cells to coordinate and appropriately respond to signals by modulating the rate of transcriptional pause re…

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes Open

Beibei Xu, C. Allard, Ana I. Álvarez‐Mercado, Taylor Fuselier, Jun Ho Kim , et al. · 2018

Estrogen Receptors: New Directions in the New Millennium Open

Sylvia C. Hewitt, Kenneth S. Korach · 2018

Nineteen years have passed since our previous review in this journal in 1999 regarding estrogen receptors. At that time, we described the current assessments of the physiological activities of estrogen and estrogen receptors. Since that ti…

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress Open

Zhenqi Zhou, Vicent Ribas, Prashant Rajbhandari, Brian G. Drew, Timothy M. Moore , et al. · 2018

Estrogen receptor α (ERα) action plays an important role in pancreatic β-cell function and survival; thus, it is considered a potential therapeutic target for the treatment of type 2 diabetes in women. However, the mechanisms underlying th…

Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation Open

Wipawee Winuthayanon, Sydney L Lierz, Karena C. Delarosa, Skylar R. Sampels, Lauren J. Donoghue , et al. · 2017

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin Open

Laurel A. Coons, Sylvia C. Hewitt, Adam Burkholder, Donald P. McDonnell, Kenneth S. Korach · 2017

Gene regulatory programs are encoded in the sequence of the DNA. Since the completion of the Human Genome Project, millions of gene regulatory elements have been identified in the human genome. Understanding how each of those sites functio…

Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1 Open

Sylvia C. Hewitt, Wipawee Winuthayanon, Sydney L Lierz, Katherine J. Hamilton, Lauren J. Donoghue , et al. · 2017

Estrogen (E2) signaling through its nuclear receptor, E2 receptor α (ERα) increases insulinlike growth factor 1 (IGF1) in the rodent uterus, which then initiates further signals via the IGF1 receptor. Directly administering IGF1 results in…

Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice Open

Sarah Hart-Unger, Yukitomo Arao, Katherine J. Hamilton, Sydney L Lierz, David E. Malarkey , et al. · 2017

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24 + CD49f hi Mammary Stem Cell-Enriched Compartment Open

Genevieve Dall, Jessica Vieusseux, Kenneth S. Korach, Yukitomo Arao, Sylvia C. Hewitt , et al. · 2017

Estrogen Hormone Biology Open

Katherine J. Hamilton, Sylvia C. Hewitt, Yukitomo Arao, Kenneth S. Korach · 2017

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females Open

Vicent Ribas, Brian G. Drew, Zhenqi Zhou, Jennifer Phun, Nareg Kalajian , et al. · 2016

ERα action in skeletal muscle is involved in the preservation of mitochondrial health and insulin sensitivity in female mice and can serve as a defense against metabolic disease in women.

Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus Open

Fabiola F. Mehta, Jieun Son, Sylvia C. Hewitt, Eun‐Jung Jang, John P. Lydon , et al. · 2016

While the function of progesterone receptor (PR) has been studied in the mouse vagina and uterus, its regulation and function in the cervix has not been described. We selectively deleted epithelial PR in the female reproductive tracts usin…

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death Open

Wipawee Winuthayanon, Miranda L. Bernhardt, Elizabeth Padilla‐Banks, Page Myers, Matthew L. Edin , et al. · 2015

Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation d…

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