Sylvia Dewilde
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View article: Structural and dynamic characterization of the hexa-coordinated globin from Spisula solidissima
Structural and dynamic characterization of the hexa-coordinated globin from Spisula solidissima Open
High energy consumption in the nervous system requires a continuous supply of O2. This role is assisted by proteins from the globin super-family in the nerve cells of invertebrates, where 'nerve hemoglobins' (nHbs) are mainly present at mM…
View article: Androglobin, a chimeric mammalian globin, is required for male fertility
Androglobin, a chimeric mammalian globin, is required for male fertility Open
Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are known to be essential for male germline prolife…
View article: Author response: Androglobin, a chimeric mammalian globin, is required for male fertility
Author response: Androglobin, a chimeric mammalian globin, is required for male fertility Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Spermatogenesis is a h…
View article: Androglobin, a chimeric mammalian globin, is required for male fertility
Androglobin, a chimeric mammalian globin, is required for male fertility Open
Spermatogenesis is a highly specialised process, involving multiple dedicated pathways and regulatory check-points. Defects ultimately lead to male sub-fertility or sterility, and numerous aspects of mammalian sperm formation remain unknow…
View article: The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease
The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease Open
Aims: Cytoglobin (CYGB) is a member of the mammalian globin family of respiratory proteins. Despite extensive research efforts, its physiological role remains largely unknown, but potential functions include reactive oxygen species (ROS) d…
View article: Structural and Functional Characterization of the Globin-Coupled Sensors of <i>Azotobacter vinelandii</i> and <i>Bordetella pertussis</i>
Structural and Functional Characterization of the Globin-Coupled Sensors of <i>Azotobacter vinelandii</i> and <i>Bordetella pertussis</i> Open
Aims: Structural and functional characterization of the globin-coupled sensors (GCSs) from Azotobacter vinelandii (AvGReg) and Bordetella pertussis (BpeGReg). Results: Ultraviolet/visible and resonance Raman spectroscopies confirm the pres…
View article: The Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment
The Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment Open
Increasing the selectivity of cancer treatments is attractive, as it has the potential to reduce side-effects of therapy. Cold atmospheric plasma (CAP) is a novel cancer treatment that disrupts the intracellular oxidative balance. Several …
View article: The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor
The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor Open
Many current anti-cancer therapies rely on increasing the intracellular reactive oxygen and nitrogen species (RONS) contents with the aim to induce irreparable damage, which subsequently results in tumor cell death. A novel tool in cancer …
View article: PO-018 Immunogenic potential of cold atmospheric plasma for the treatment of pancreatic cancer
PO-018 Immunogenic potential of cold atmospheric plasma for the treatment of pancreatic cancer Open
Introduction Pancreatic ductal adenocarcinoma (PDAC) is a tumour with a fibroblastic stroma compartment that consists of pancreatic stellate cells (PSC) which play a complex role in supporting carcinogenesis, immunosuppression and therapy…
View article: Characterization of the Heme Pocket Structure and Ligand Binding Kinetics of Non-symbiotic Hemoglobins from the Model Legume Lotus japonicus
Characterization of the Heme Pocket Structure and Ligand Binding Kinetics of Non-symbiotic Hemoglobins from the Model Legume Lotus japonicus Open
Plant hemoglobins (Hbs) are found in nodules of legumes and actinorhizal plants but also in non-symbiotic organs of monocots and dicots. Non-symbiotic Hbs (nsHbs) have been classified into two phylogenetic groups. Class 1 nsHbs show an ext…