Sylvia Santosa
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View article: Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer
Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer Open
Basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and exhibits a recurrent large chromosomal deletion in chromosome 4p (chr4p). Chr4p loss is associated with poor survival, evolves early in tumorigenesis and …
View article: The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss
The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss Open
Introduction Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modi…
View article: Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?
Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities? Open
In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic lo…
View article: Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region
Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region Open
Objective We aimed to examine the effect of age of obesity onset, sex, and their interaction on abdominal and femoral subcutaneous adipose tissue (SAT) morphology (degree of adipocyte hyperplasia or hypertrophy). Methods In this cross‐sect…
View article: Altered Intramyocellular Lipids Use with Exercise in Males with Childhood-Onset Obesity
Altered Intramyocellular Lipids Use with Exercise in Males with Childhood-Onset Obesity Open
Objective Compared to adulthood-onset obesity (AO), those with childhood-onset obesity (CO) are at greater risk of metabolic disease. However, the differences between these two obesity phenotypes are not clear. The aim of this study is to …
View article: Improvements in cardiorespiratory fitness, muscle strength and body composition to modest weight loss are similar in those with adult‐ versus childhood‐onset obesity
Improvements in cardiorespiratory fitness, muscle strength and body composition to modest weight loss are similar in those with adult‐ versus childhood‐onset obesity Open
Summary Adults who have had obesity from childhood are at greater risk of obesity‐related comorbidities compared to those who only develop obesity in adulthood. The main way of mitigating these risks in obesity is with weight loss, which h…
View article: Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss
Senescence markers in subcutaneous preadipocytes differ in childhood‐ versus adult‐onset obesity before and after weight loss Open
Objective The aim of this study was to determine the effect of age of obesity onset on senescence‐related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss. Methods A…
View article: Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome
Editorial: The Effect of Carbohydrate Restriction on Cancer and Metabolic Syndrome Open
EDITORIAL article Front. Nutr., 14 February 2022 | https://doi.org/10.3389/fnut.2022.823302
View article: Modified Delphi Process to Identify Research Priorities and Measures for Adult Lifestyle Programs to Address Type 2 Diabetes and Other Cardiometabolic Risk Conditions
Modified Delphi Process to Identify Research Priorities and Measures for Adult Lifestyle Programs to Address Type 2 Diabetes and Other Cardiometabolic Risk Conditions Open
This first effort confirms broad agreement on research priorities and limited agreement on core indicators/measures. The results provide a starting point for further development of common measures for implementation research in lifestyle s…
View article: Assessing the contribution of traditional foods to food security for the Wapekeka First Nation of Canada
Assessing the contribution of traditional foods to food security for the Wapekeka First Nation of Canada Open
The food security crisis and disproportionately high burden of dietary related disease amongst northern Indigenous populations in Canada continues to be a troubling reality with little sign of improvement. The Government of Canada is respo…
View article: Editorial: Advances in Dietary Fat Absorption
Editorial: Advances in Dietary Fat Absorption Open
EDITORIAL article Front. Physiol., 08 June 2021 | https://doi.org/10.3389/fphys.2021.707403
View article: Association between rs174537 <i>FADS1</i> polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity
Association between rs174537 <i>FADS1</i> polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity Open
Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status…
View article: Association between rs174537 <i>FADS1</i> polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity
Association between rs174537 <i>FADS1</i> polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity Open
Fatty acid desaturase 1 (FADS1) polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between FADS1 variants and SAT inflammatory status…
View article: Acetyl-CoA Regulation, OXPHOS Integrity and Leptin Levels Are Different in Females With Childhood vs Adulthood Onset of Obesity
Acetyl-CoA Regulation, OXPHOS Integrity and Leptin Levels Are Different in Females With Childhood vs Adulthood Onset of Obesity Open
Although childhood-onset obesity (CO) and adulthood-onset obesity (AO) are known to lead to distinctive clinical manifestations and disease risks, the fundamental differences between them are largely unclear. The aim of the current study i…
View article: Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight
Meeting fruit and vegetable consumption and physical activity recommendations among adolescents intending to lose weight Open
Two-thirds of adolescents who are overweight or have obesity report weight loss intentions. Most report using weight loss strategies consistent with expert recommendations for obesity prevention; however whether they meet recommended fruit…
View article: Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage
Acute Testosterone Deficiency Alters Adipose Tissue Fatty Acid Storage Open
Context Although the long-term effects of testosterone on adipose tissue lipid metabolism in men have been defined, the short-term regulation of these effects is not well understood. Objective We examined the effects of acute testosterone …
View article: Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia
Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia Open
Our results suggest estrogen and progesterone may have different effects on the regulation of FA metabolism and that acute sex steroid deficiency in women does not alter fat storage and oxidation.