Sylvia Whittle
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View article: A trackable trinuclear platinum complex for breast cancer treatment
A trackable trinuclear platinum complex for breast cancer treatment Open
Cancer remains a leading cause of death, with triple-negative breast cancer (TNBC) being particularly significant due to limited treatment options. As such, there is interest in anticancer polynuclear platinum(II) complexes, attributed to …
View article: Multiscale topological analysis of kinetoplast DNA via high-resolution AFM
Multiscale topological analysis of kinetoplast DNA via high-resolution AFM Open
Kinetoplast DNA is a complex nanoscale network, naturally assembled from thousands of interconnected DNA circles within the mitochondrion of certain parasites. Despite the relevance of this molecule to parasitology and the recent discovery…
View article: Under or Over? Tracing Complex DNA Structures with High Resolution Atomic Force Microscopy
Under or Over? Tracing Complex DNA Structures with High Resolution Atomic Force Microscopy Open
The topology of DNA plays a crucial role in the regulation of cellular processes and genome stability. Despite its significance, DNA topology remains challenging to determine due to the length and conformational complexity of individual to…
View article: Multiscale topological analysis of kinetoplast DNA <i>via</i> high-resolution AFM
Multiscale topological analysis of kinetoplast DNA <i>via</i> high-resolution AFM Open
High-resolution atomic force microscopy and customised, open-source image analysis on single kinetoplast DNA molecules reveals structural heterogeneity and complex catenation behaviour across several length scales.